| UniProt ID | ALKB4_HUMAN | |
|---|---|---|
| UniProt AC | Q9NXW9 | |
| Protein Name | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 | |
| Gene Name | ALKBH4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 302 | |
| Subcellular Localization | Cytoplasm. Nucleus. Midbody. Associates with the contractile ring and midbody. | |
| Protein Description | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.. | |
| Protein Sequence | MAAAAAETPEVLRECGCKGIRTCLICERQRGSDPPWELPPAKTYRFIYCSDTGWAVGTEESDFEGWAFPFPGVMLIEDFVTREEEAELVRLMDRDPWKLSQSGRRKQDYGPKVNFRKQKLKTEGFCGLPSFSREVVRRMGLYPGLEGFRPVEQCNLDYCPERGSAIDPHLDDAWLWGERLVSLNLLSPTVLSMCREAPGSLLLCSAPSAAPEALVDSVIAPSRSVLCQEVEVAIPLPARSLLVLTGAARHQWKHAIHRRHIEARRVCVTFRELSAEFGPGGRQQELGQELLRIALSFQGRPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAAAAETP ------CCCHHCCCH | 13.05 | 22223895 | |
| 8 | Phosphorylation | MAAAAAETPEVLREC CCCHHCCCHHHHHHH | 21.74 | 14702039 | |
| 39 | Ubiquitination | SDPPWELPPAKTYRF CCCCCCCCCCCCEEE | 18.45 | 24816145 | |
| 98 | Ubiquitination | LMDRDPWKLSQSGRR HHHCCCCCCCCCCCC | 43.58 | - | |
| 109 | Phosphorylation | SGRRKQDYGPKVNFR CCCCCCCCCCCCCHH | 32.60 | 46162425 | |
| 112 | Ubiquitination | RKQDYGPKVNFRKQK CCCCCCCCCCHHHHH | 45.51 | 24816145 | |
| 121 | Ubiquitination | NFRKQKLKTEGFCGL CHHHHHCCCCCCCCC | 52.12 | - | |
| 158 | Phosphorylation | VEQCNLDYCPERGSA HHHCCCCCCCCCCCC | 17.05 | 50564677 | |
| 204 | Glutathionylation | APGSLLLCSAPSAAP CCCCEEEECCCCCCC | 3.08 | 22555962 | |
| 245 | Phosphorylation | ARSLLVLTGAARHQW HHHHHHHHHHHHHHH | 19.80 | 28555341 | |
| 249 | Dimethylation | LVLTGAARHQWKHAI HHHHHHHHHHHHHHH | 23.23 | - | |
| 249 | Methylation | LVLTGAARHQWKHAI HHHHHHHHHHHHHHH | 23.23 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ALKB4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ALKB4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ALKB4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DTX2_HUMAN | DTX2 | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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