| UniProt ID | AACS_MOUSE | |
|---|---|---|
| UniProt AC | Q9D2R0 | |
| Protein Name | Acetoacetyl-CoA synthetase | |
| Gene Name | Aacs | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 672 | |
| Subcellular Localization | Cytoplasm, cytosol. | |
| Protein Description | Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).. | |
| Protein Sequence | MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYNDLYHWSVRSYMDFWAEFWKFSGIVYSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIVKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSVFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHMLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPVETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSSVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKAVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKFPGVWAHGDYCRINPKTGGIIMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKRIRDAIRLGLSARHVPSLILETRGIPYTLNGKKVEVAVKQVMAGRTVEHRGAFSNPETLDLYRDIPELQDF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Glutathionylation | RAAVGTACGLALGNY HHHHHHHHHHHCCCC | 4.63 | 24333276 | |
| 222 | Acetylation | KEHGHLEKLQRVVKG CCCCHHHHHHHHHCC | 57.17 | 22826441 | |
| 228 | Malonylation | EKLQRVVKGLPDLQR HHHHHHHCCCCCHHE | 52.45 | 26320211 | |
| 391 | Acetylation | WLSVLEEKDMKPVET HHHHHHHCCCCCCEE | 54.47 | 23954790 | |
| 410 | Phosphorylation | TLHTILSTGSPLKAQ HHHHHHHCCCCCCCC | 37.93 | 26060331 | |
| 412 | Phosphorylation | HTILSTGSPLKAQSY HHHHHCCCCCCCCCH | 27.44 | 72262555 | |
| 524 | Phosphorylation | GVWAHGDYCRINPKT CCEECCCCEEECCCC | 6.55 | 22817900 | |
| 530 | Ubiquitination | DYCRINPKTGGIIML CCEEECCCCCCEEEE | 56.14 | 27667366 | |
| 530 | Malonylation | DYCRINPKTGGIIML CCEEECCCCCCEEEE | 56.14 | 26320211 | |
| 601 | Acetylation | TFQPDLVKRIRDAIR CCCHHHHHHHHHHHH | 49.78 | 23954790 | |
| 601 | Malonylation | TFQPDLVKRIRDAIR CCCHHHHHHHHHHHH | 49.78 | 26320211 | |
| 618 | Phosphorylation | LSARHVPSLILETRG CCCCCCCHHHEEECC | 27.27 | 25338131 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AACS_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AACS_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AACS_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AACS_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling."; Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.; J. Immunol. 179:5864-5876(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-524, AND MASSSPECTROMETRY. | |
