CGAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CGAT1_HUMAN
• UniProt AC: Q8TDX6
• Protein Name: Chondroitin sulfate N-acetylgalactosaminyltransferase 1 {ECO:0000305}
• Gene Name: CSGALNACT1 {ECO:0000312|HGNC:HGNC:24290}
• Organism: Homo sapiens (Human).
• Sequence Length: 532
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .
• Protein Description: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification. [PubMed: 11788602]
• Protein Sequence: MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERSEQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDELVEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLAKRVDKFRQFMQNFREMCIEQDGRVHLTVVYFGKEEINEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKTSSKKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	1.73	26503514
5 (in isoform 2)	Phosphorylation	-	14.73	26503514
18 (in isoform 2)	Phosphorylation	-	1.53	26503514
101	O-linked_Glycosylation	RNGQYQASDAAGLGL HCCCCCHHHCCCCCC	16.56	OGP
315	N-linked_Glycosylation	EVKGILENTSKAANF HHHHHHHCCCCCCCC	46.32	UniProtKB CARBOHYD
324	N-linked_Glycosylation	SKAANFRNFTFIQLN CCCCCCCCEEEEEEC	35.85	UniProtKB CARBOHYD
364	Phosphorylation	CDVDIYFTSEFLNTC EEEEEEECHHHHHHC	15.46	-
370	Phosphorylation	FTSEFLNTCRLNTQP ECHHHHHHCCCCCCC	10.93	-
375	Phosphorylation	LNTCRLNTQPGKKVF HHHCCCCCCCCCEEE	40.51	-
486	Phosphorylation	KRCMDELTPEQYKMC CCCHHCCCHHHHHHH	23.80	-
490	Phosphorylation	DELTPEQYKMCMQSK HCCCHHHHHHHHHHH	10.06	-
503	Phosphorylation	SKAMNEASHGQLGML HHHHHHHCCCHHHHH	23.21	-
527	Phosphorylation	LRKQKQKTSSKKT-- HHHHHHHCCCCCC--	35.42	-
528	Phosphorylation	RKQKQKTSSKKT--- HHHHHHCCCCCC---	47.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CGAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CGAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CGAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX6_HUMAN	STX6	physical	22939629
CGAT2_HUMAN	CSGALNACT2	physical	26186194
ZNT1_HUMAN	SLC30A1	physical	26186194
GPC5B_HUMAN	GPRC5B	physical	26186194
BIG1_HUMAN	ARFGEF1	physical	26186194
BIG2_HUMAN	ARFGEF2	physical	26186194
TM214_HUMAN	TMEM214	physical	26186194
F234B_HUMAN	KIAA1467	physical	26186194
AT2B3_HUMAN	ATP2B3	physical	26186194
TMUB1_HUMAN	TMUB1	physical	26186194
TMX4_HUMAN	TMX4	physical	26186194
TIM_HUMAN	TIMELESS	physical	26186194
CGAT2_HUMAN	CSGALNACT2	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
BIG1_HUMAN	ARFGEF1	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
BIG2_HUMAN	ARFGEF2	physical	28514442
AT2B3_HUMAN	ATP2B3	physical	28514442
GPC5B_HUMAN	GPRC5B	physical	28514442
TIM_HUMAN	TIMELESS	physical	28514442
TMX4_HUMAN	TMX4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.