NP1L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NP1L2_HUMAN
• UniProt AC: Q9ULW6
• Protein Name: Nucleosome assembly protein 1-like 2
• Gene Name: NAP1L2
• Organism: Homo sapiens (Human).
• Sequence Length: 460
• Subcellular Localization: Nucleus .
• Protein Description: Acidic protein which may be involved in interactions with other proteins or DNA..
• Protein Sequence: MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	LIGYVLDTDFVESLP EEEEEECCCHHHCCC	27.46	-
109	Ubiquitination	ESLPVKVKYRVLALK HCCCCHHHHHHHHHH	22.94	-
118	Ubiquitination	RVLALKKLQTRAANL HHHHHHHHHHHHHHH	6.34	-
125	Ubiquitination	LQTRAANLESKFLRE HHHHHHHHHHHHHHH	7.24	-
127	Phosphorylation	TRAANLESKFLREFH HHHHHHHHHHHHHHH	31.69	21406692
128	Ubiquitination	RAANLESKFLREFHD HHHHHHHHHHHHHHH	38.76	-
131	Ubiquitination	NLESKFLREFHDIER HHHHHHHHHHHHHHH	47.90	-
150	Ubiquitination	MYQPLLEKRRQIINA HHHHHHHHHHHHHHH	53.50	-
159	Phosphorylation	RQIINAIYEPTEEEC HHHHHHHHCCCHHHC	17.28	-
169	Ubiquitination	TEEECEYKSDSEDCD CHHHCCCCCCCCCCC	26.03	-
206	Phosphorylation	EDDGYEDYYYDYAVE CCCCCEEEECEEECC	7.62	22468782
207	Phosphorylation	DDGYEDYYYDYAVEE CCCCEEEECEEECCH	11.37	22468782
208	Phosphorylation	DGYEDYYYDYAVEEE CCCEEEECEEECCHH	9.03	22468782
255	Phosphorylation	LKNVDTLTPLIKKYD HCCCCHHHHHHHHCC	20.38	24719451
260	Ubiquitination	TLTPLIKKYDEPILK HHHHHHHHCCHHHHH	51.44	-
267	Ubiquitination	KYDEPILKLLTDIKV HCCHHHHHHHHEEEE	42.02	20972266
273	Ubiquitination	LKLLTDIKVKLSDPG HHHHHEEEEECCCCC	35.81	-
296	Phosphorylation	FHFKPNEYFKNELLT EECCCCHHHCCCCCC	26.88	-
303	Phosphorylation	YFKNELLTKTYVLKS HHCCCCCCCEEEEEC	33.68	-
306	Phosphorylation	NELLTKTYVLKSKLA CCCCCCEEEEECCCC	12.82	-
307	Ubiquitination	ELLTKTYVLKSKLAY CCCCCEEEEECCCCC	7.03	-
311	Ubiquitination	KTYVLKSKLAYYDPH CEEEEECCCCCCCCC	35.23	29967540
339	Acetylation	EIDWNEGKNVTLKTI EECCCCCCCEEEEEH	41.91	158709
342	Phosphorylation	WNEGKNVTLKTIKKK CCCCCCEEEEEHHHH	31.75	20873877
344	Ubiquitination	EGKNVTLKTIKKKQK CCCCEEEEEHHHHHH	38.55	32015554
344	Acetylation	EGKNVTLKTIKKKQK CCCCEEEEEHHHHHH	38.55	158713
345	Phosphorylation	GKNVTLKTIKKKQKH CCCEEEEEHHHHHHH	40.93	28857561
449	Ubiquitination	EEVKACCKNLEALVE HHHHHHHHCHHHHHH	65.53	30230243

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NP1L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NP1L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NP1L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CANB1_HUMAN	PPP3R1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.