SCNND_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNND_HUMAN
• UniProt AC: P51172
• Protein Name: Amiloride-sensitive sodium channel subunit delta
• Gene Name: SCNN1D
• Organism: Homo sapiens (Human).
• Sequence Length: 638
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..
• Protein Sequence: MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24 (in isoform 2)	Phosphorylation	-	6.27	22210691
29 (in isoform 2)	Phosphorylation	-	59.49	22210691
43 (in isoform 2)	Phosphorylation	-	68.62	22210691
61	Phosphorylation	ASFRELLTFFCTNAT HHHHHHHHHHHCCCC	27.56	25072903
65	Phosphorylation	ELLTFFCTNATIHGA HHHHHHHCCCCHHHH	23.80	25072903
68	Phosphorylation	TFFCTNATIHGAIRL HHHHCCCCHHHHHHH	18.64	25072903
78	Phosphorylation	GAIRLVCSRGNRLKT HHHHHHCCCCCCCCC	35.43	-
122	Phosphorylation	VLMAVSVHSERKLLP EEEEEEECCCCCCCC	19.21	22210691
127	Phosphorylation	SVHSERKLLPLVTLC EECCCCCCCCEEEEC	8.14	22210691
132	Phosphorylation	RKLLPLVTLCDGNPR CCCCCEEEECCCCCC	29.38	-
141	Phosphorylation	CDGNPRRPSPVLRHL CCCCCCCCCHHHHHH	44.24	22210691
166	N-linked_Glycosylation	IDSLYNVNLSKGRAA HHHHEECCCCCCCHH	34.65	UniProtKB CARBOHYD
175	Phosphorylation	SKGRAALSATVPRHE CCCCHHHCCCCCCCC	19.71	23403867
177	Phosphorylation	GRAALSATVPRHEPP CCHHHCCCCCCCCCC	27.89	23403867
199	Phosphorylation	RLQRLSHSGSRVRVG HHHHCCCCCCCEEEE	34.78	24275569
330	N-linked_Glycosylation	AGIRVMVHGRNHTPF HCCEEEEECCCCCCC	16.05	-
342	Phosphorylation	TPFLGHHSFSVRPGT CCCCCEEEEEECCCC	17.34	-
344	Phosphorylation	FLGHHSFSVRPGTEA CCCEEEEEECCCCEE	21.89	-
349	Phosphorylation	SFSVRPGTEATISIR EEEECCCCEEEEEEE	25.73	20363803
352	Phosphorylation	VRPGTEATISIREDE ECCCCEEEEEEEHHH	14.71	20363803
354	Phosphorylation	PGTEATISIREDEVH CCCEEEEEEEHHHHH	15.96	24719451
384	N-linked_Glycosylation	VEVELLHNTSYTRQA EEEEEEECCCCHHHH	30.59	UniProtKB CARBOHYD
548	N-linked_Glycosylation	LSLLELLELLLDASA HHHHHHHHHHHHHHH	50.42	-
571	Phosphorylation	RLRRAWFSWPRASPA HHHEEECCCCCCCCC	26.01	24719451
626	Phosphorylation	AGVSAEESWAGPQPL CCCCHHHCCCCCCCC	17.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCNND_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNND_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNND_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD1_HUMAN	COMMD1	physical	21741370
COMD1_HUMAN	COMMD1	physical	14645214
ABHGA_HUMAN	ABHD16A	physical	28514442
MTFR2_HUMAN	MTFR2	physical	28514442
TAP2_HUMAN	TAP2	physical	28514442
D19L1_HUMAN	DPY19L1	physical	28514442
CSTN3_HUMAN	CLSTN3	physical	28514442
AMGO1_HUMAN	AMIGO1	physical	28514442
CFA74_HUMAN	CFAP74	physical	28514442
LRRC3_HUMAN	LRRC3	physical	28514442
CLPT1_HUMAN	CLPTM1	physical	28514442
ANGE1_HUMAN	ANGEL1	physical	28514442
ALG9_HUMAN	ALG9	physical	28514442
ERMP1_HUMAN	ERMP1	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
POMT1_HUMAN	POMT1	physical	28514442
CALX_HUMAN	CANX	physical	28514442
DJC16_HUMAN	DNAJC16	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00594: Amiloride
• DB00384: Triamterene