MUT7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MUT7_HUMAN
• UniProt AC: Q8N9H8
• Protein Name: Exonuclease mut-7 homolog
• Gene Name: EXD3
• Organism: Homo sapiens (Human).
• Sequence Length: 876
• Protein Description: Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity)..
• Protein Sequence: MDPGDPAGDPAAGERHRMGRDPLLLLQALQTLWSTRERKQLREEAWRGFAALDDPLAGLLDMLESCRGQRGEGPSLAAWISHQLQCWLQAQPCPSLAQHSLRLKQLQARAVKVLTESPPSLAAPLASIFQLQDADRSCLLAHVHRLHHEGRFREAATLGATLKLQSELGVEKMSIPLLLQDKVALVERYVAGFPDLQRRLLVLMDSWCQPGFDIKDVARRYPEVTSLSLEKLSPKALSRQVLRLQERYGVAPALCPNAAIQQRLAALRHLCHKRFVEKSLSQENWTDHVQGLVGQSPWLQEQLSQLLVSHSDPVTAAQCAMELLLPEERLPAAVAVELRRFRLQGRATEADSRLEVKDMKDRYYQLPIPRENVHLLASWEDLTRHEGALLQCHQVVGVDVEWTPVFVAGGRPRPSLLQVAVEGHVFLLDVLALSQPPTGQGAQAFSRLVAQLLSDPSITKLGYGMVGDLQKLGTSCPALAHVEKQILGGMDLLLVHRQMRVASVPAPAVDRARELRGLSLLVQQVLGTALDKTQQLSNWDRRPLCEEQVIYAAADAYCLLEVHQALCREPARFHLSEDLAGSRRPRHRERPGARKPPGLQKASAPAAPRQVPVAVAVSEGAAPQIPARAFRVVCDNMLQGLARSLRCLGVDARMLGNGEDHRRAAEVARQEGRIILTSGQPFHKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTHADIFSRCQACNCDQYLKVSRDMMKQLMWLSSHQEGPRSSGDEATQSQAVQEPGPAPDAAPEGCTYDRPCRWLQMADLRAETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFWDGSHLGRVATHFRDMLESAPSPCEPSPAPSPASSPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDPGDPAGDP -----CCCCCCCCCC	48.03	-
3	Phosphorylation	-----MDPGDPAGDP -----CCCCCCCCCC	48.03	-
7	Phosphorylation	-MDPGDPAGDPAAGE -CCCCCCCCCCCCCH	39.50	-
7	Phosphorylation	-MDPGDPAGDPAAGE -CCCCCCCCCCCCCH	39.50	-
29	Phosphorylation	PLLLLQALQTLWSTR HHHHHHHHHHHHCHH	2.29	-
29	Phosphorylation	PLLLLQALQTLWSTR HHHHHHHHHHHHCHH	2.29	-
37	Phosphorylation	QTLWSTRERKQLREE HHHHCHHHHHHHHHH	65.40	-
37	Phosphorylation	QTLWSTRERKQLREE HHHHCHHHHHHHHHH	65.40	-
39	Phosphorylation	LWSTRERKQLREEAW HHCHHHHHHHHHHHH	49.26	-
39	Phosphorylation	LWSTRERKQLREEAW HHCHHHHHHHHHHHH	49.26	-
51	Phosphorylation	EAWRGFAALDDPLAG HHHHHHHHHCCHHHH	14.84	19690332
51	Phosphorylation	EAWRGFAALDDPLAG HHHHHHHHHCCHHHH	14.84	19690332
58	Phosphorylation	ALDDPLAGLLDMLES HHCCHHHHHHHHHHH	34.16	-
66	Phosphorylation	LLDMLESCRGQRGEG HHHHHHHHCCCCCCC	4.07	-
68	Phosphorylation	DMLESCRGQRGEGPS HHHHHHCCCCCCCHH	26.34	-
80	Phosphorylation	GPSLAAWISHQLQCW CHHHHHHHHHHHHHH	1.95	19690332
89	Phosphorylation	HQLQCWLQAQPCPSL HHHHHHHHCCCCCHH	17.28	19690332
89	Phosphorylation	HQLQCWLQAQPCPSL HHHHHHHHCCCCCHH	17.28	19690332
189	Phosphorylation	KVALVERYVAGFPDL HHHHHHHHHHCCCHH	4.91	-
206	Phosphorylation	RLLVLMDSWCQPGFD HHHHHHHCCCCCCCC	18.78	-
503	Phosphorylation	HRQMRVASVPAPAVD HCHHHHHCCCCCHHH	26.27	28674151
644	Phosphorylation	MLQGLARSLRCLGVD HHHHHHHHHHHHCCC	17.98	23312004
750	Phosphorylation	MKQLMWLSSHQEGPR HHHHHHHHHCCCCCC	15.40	24719451
751	Phosphorylation	KQLMWLSSHQEGPRS HHHHHHHHCCCCCCC	27.33	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MUT7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MUT7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MUT7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAZP2_HUMAN	DAZAP2	physical	19060904
MUT7_HUMAN	EXD3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.