FBX3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX3_MOUSE
• UniProt AC: Q9DC63
• Protein Name: F-box only protein 3
• Gene Name: Fbxo3
• Organism: Mus musculus (Mouse).
• Sequence Length: 480
• Subcellular Localization: Nucleus. Colocalizes with PML at the peripheries of nuclear bodies..
• Protein Description: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity)..
• Protein Sequence: MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYWLISEEEKAGKSQCWRSLFIETYSDVGRYIDHYAAIKKAWRDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDADENESDEGEGEARRRRVFDVPIRRRRCSRLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Ubiquitination	WLISEEEKAGKSQCW EEEEHHHHCCCCHHH	66.76	22790023
93	Phosphorylation	VGRYIDHYAAIKKAW HHHHHHHHHHHHHHH	8.25	28066266
97	Ubiquitination	IDHYAAIKKAWRDLK HHHHHHHHHHHHHHH	31.54	22790023
113	Dimethylation	YLEPRCPRMVLSLKE HHCCCCCHHEEECCC	31.31	-
117	Phosphorylation	RCPRMVLSLKEGARE CCCHHEEECCCCCCH	26.45	30387612
119	Ubiquitination	PRMVLSLKEGAREED CHHEEECCCCCCHHH	51.21	22790023
153	Ubiquitination	YRIHNGQKLVVPGLL EEEECCCEEEECCHH	44.65	22790023
218	Ubiquitination	EAAEGRNKNEVFYQC HHHCCCCCCCCEEEC	53.80	22790023
337	Ubiquitination	YWRITNAKGDVEEVQ EEEEECCCCCCEEEC	58.68	22790023
390	Ubiquitination	HFLYFKDKVFNVAIP EEEEECCCEEEEEEC	49.68	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FBX3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.