ATS17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATS17_HUMAN
• UniProt AC: Q8TE56
• Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 17
• Gene Name: ADAMTS17
• Organism: Homo sapiens (Human).
• Sequence Length: 1095
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Sequence: MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	RRDLRFLSRGFEVEE HHHHHHHHCCCCHHH	27.87	46159251
167	N-linked_Glycosylation	QVLIQPLNNSQGPFS EEEEEECCCCCCCCC	53.44	UniProtKB CARBOHYD
185	Phosphorylation	HLIRRKWSLTPSPSA HHHHCCEECCCCCCH	25.96	30576142
419	Ubiquitination	IMSGEWVKGRNPSDL EECCCCCCCCCHHHC	53.91	-
446	Phosphorylation	FLKSKVSTCLLVTDP HHHHCCEEEEEECCC	15.34	30631047
451	Phosphorylation	VSTCLLVTDPRSQHT CEEEEEECCCCCCCE	40.01	30631047
483	N-linked_Glycosylation	CQILFGMNATFCRNM HHHHHCCCHHHHCCH	35.89	UniProtKB CARBOHYD
616	Phosphorylation	CQAHDRLSPKKKGLL HHHHCCCCCCCCCCE	35.25	26091039
758	Phosphorylation	KISAKGPTKLPLHLM HHHCCCCCCCCEEEE	54.61	21712546
785	N-linked_Glycosylation	YEYTVPVNRTAENQS EEEEEECCCCCCCCC	29.52	UniProtKB CARBOHYD
790	N-linked_Glycosylation	PVNRTAENQSEPEKP ECCCCCCCCCCCCCC	48.49	UniProtKB CARBOHYD
832	N-linked_Glycosylation	VSCTRIVNKTTTLVN EEEEEEECCCCEEEC	33.32	UniProtKB CARBOHYD
839	N-linked_Glycosylation	NKTTTLVNDSDCPQA CCCCEEECCCCCCCC	46.29	UniProtKB CARBOHYD
864	Methylation	NLHPCQSRWVAGPWS CCCCCCCCCCCCCCC	13.15	-
887	Phosphorylation	GFQHREVTCVYQLQN CCCCCEEEEEEEECC	7.47	28787133
890	Phosphorylation	HREVTCVYQLQNGTH CCEEEEEEEECCCCE	12.97	28787133
894	N-linked_Glycosylation	TCVYQLQNGTHVATR EEEEEECCCCEEEEC	66.96	UniProtKB CARBOHYD
896	Phosphorylation	VYQLQNGTHVATRPL EEEECCCCEEEECEE	22.26	28787133
900	Phosphorylation	QNGTHVATRPLYCPG CCCCEEEECEEECCC	31.56	28787133
1095	Phosphorylation	MRQPPPNS------- HCCCCCCC-------	47.58	46159255

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATS17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATS17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATS17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ATS17_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.