CSN7B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN7B_MOUSE
• UniProt AC: Q8BV13
• Protein Name: COP9 signalosome complex subunit 7b
• Gene Name: Cops7b
• Organism: Mus musculus (Mouse).
• Sequence Length: 264
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)..
• Protein Sequence: MAGEQKPSSNLLEQFILLAKGTSGSALTTLISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSVAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKKTLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGEQKPSS ------CCCCCCCCC	30.17	-
221	Ubiquitination	SNIKKTLKATASSSA HHHHHHHHHHHCCCH	49.26	-
223	Phosphorylation	IKKTLKATASSSAQE HHHHHHHHHCCCHHH	26.03	30635358
225	Phosphorylation	KTLKATASSSAQEME HHHHHHHCCCHHHHH	22.07	30635358
226	Phosphorylation	TLKATASSSAQEMEQ HHHHHHCCCHHHHHH	27.51	30635358
227	Phosphorylation	LKATASSSAQEMEQQ HHHHHCCCHHHHHHH	31.32	30635358
252	Acetylation	EQRQPTKKMSKVKGL CCCCCCHHHHHHHHH	51.38	7844435
262	Phosphorylation	KVKGLVSSRH----- HHHHHHCCCC-----	27.22	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN7B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN7B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN7B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CSN7B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.