ZBT46_HUMAN - dbPTM
ZBT46_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZBT46_HUMAN
UniProt AC Q86UZ6
Protein Name Zinc finger and BTB domain-containing protein 46
Gene Name ZBTB46
Organism Homo sapiens (Human).
Sequence Length 589
Subcellular Localization Nucleus .
Protein Description Function as a transcriptional repressor for PRDM1..
Protein Sequence MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELAEFEIGASSSSSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHDGGSSYGKEDQEPKADGPDDVSSQPLWPGDVGYGPLRIKEEQVSPSQYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNKETVRHITQQVEDDSRASSPVPSFLPTSGWPFSSRDSNADLSVTEASSSDSRGERAELYAQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCAGRGMAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGLAPEDALLADDKDEEDSPRPRSPPGGPDKDFAWLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationRKEDMEITSHYRHLL
HHHHHHHHHHHHHHH		8.9928060719
12PhosphorylationKEDMEITSHYRHLLR
HHHHHHHHHHHHHHH		24.9628060719
14PhosphorylationDMEITSHYRHLLREL
HHHHHHHHHHHHHHH		10.2528060719
107PhosphorylationRNVIEVMSAASFLQM
CCHHHHHHHHHHHHH		26.3424043423
110PhosphorylationIEVMSAASFLQMTDI
HHHHHHHHHHHHHHH		26.6324043423
115PhosphorylationAASFLQMTDIVQACH
HHHHHHHHHHHHHHH		15.0424043423
149PhosphorylationAEFEIGASSSSSTEA
EEEECCCCCCCCHHH		26.07-
166PhosphorylationSAVMAGRSISPWLAR
HHHHCCCCCCHHHHH		26.8823403867
168PhosphorylationVMAGRSISPWLARRT
HHCCCCCCHHHHHCC		15.9819664994
175PhosphorylationSPWLARRTSPANSSG
CHHHHHCCCCCCCCC		33.2427251275
176PhosphorylationPWLARRTSPANSSGD
HHHHHCCCCCCCCCC		21.8725849741
180PhosphorylationRRTSPANSSGDSAIA
HCCCCCCCCCCCCEE		37.4930576142
181PhosphorylationRTSPANSSGDSAIAS
CCCCCCCCCCCCEEE		46.5630576142
184PhosphorylationPANSSGDSAIASCHD
CCCCCCCCCEEECCC		25.7123312004
188PhosphorylationSGDSAIASCHDGGSS
CCCCCEEECCCCCCC		13.0830576142
194PhosphorylationASCHDGGSSYGKEDQ
EECCCCCCCCCCCCC		26.3923312004
195PhosphorylationSCHDGGSSYGKEDQE
ECCCCCCCCCCCCCC		40.9723312004
196PhosphorylationCHDGGSSYGKEDQEP
CCCCCCCCCCCCCCC		33.6323312004
212PhosphorylationADGPDDVSSQPLWPG
CCCCCCCCCCCCCCC		30.1928348404
213PhosphorylationDGPDDVSSQPLWPGD
CCCCCCCCCCCCCCC		35.3528348404
229SumoylationGYGPLRIKEEQVSPS
CCCCEEECEEECCHH		49.0828112733
229UbiquitinationGYGPLRIKEEQVSPS
CCCCEEECEEECCHH		49.08-
229SumoylationGYGPLRIKEEQVSPS
CCCCEEECEEECCHH		49.08-
234PhosphorylationRIKEEQVSPSQYGGS
EECEEECCHHHCCCC		20.6628112733
236PhosphorylationKEEQVSPSQYGGSEL
CEEECCHHHCCCCCC		28.6423312004
238PhosphorylationEQVSPSQYGGSELPS
EECCHHHCCCCCCCC		28.0023186163
245PhosphorylationYGGSELPSAKDGAVQ
CCCCCCCCCCCCCCC		61.6524719451
254PhosphorylationKDGAVQNSFSEQSAG
CCCCCCCCCCCCCCC		17.0428258704
259PhosphorylationQNSFSEQSAGDAWQP
CCCCCCCCCCCCCCC		30.1228258704
290PhosphorylationTQQVEDDSRASSPVP
HHHHHCCCCCCCCCC		41.9125849741
293PhosphorylationVEDDSRASSPVPSFL
HHCCCCCCCCCCCCC		33.7827050516
294PhosphorylationEDDSRASSPVPSFLP
HCCCCCCCCCCCCCC		29.0027050516
298PhosphorylationRASSPVPSFLPTSGW
CCCCCCCCCCCCCCC		39.3828102081
302PhosphorylationPVPSFLPTSGWPFSS
CCCCCCCCCCCCCCC		41.8630206219
303PhosphorylationVPSFLPTSGWPFSSR
CCCCCCCCCCCCCCC		36.6030206219
308PhosphorylationPTSGWPFSSRDSNAD
CCCCCCCCCCCCCCC		22.0030206219
309PhosphorylationTSGWPFSSRDSNADL
CCCCCCCCCCCCCCC		40.2530206219
312PhosphorylationWPFSSRDSNADLSVT
CCCCCCCCCCCCEEE		32.5730576142
319PhosphorylationSNADLSVTEASSSDS
CCCCCEEEECCCCCC		23.5827251275
322PhosphorylationDLSVTEASSSDSRGE
CCEEEECCCCCCHHH		24.9230576142
323PhosphorylationLSVTEASSSDSRGER
CEEEECCCCCCHHHH		45.2530576142
324PhosphorylationSVTEASSSDSRGERA
EEEECCCCCCHHHHH		36.7927251275
326PhosphorylationTEASSSDSRGERAEL
EECCCCCCHHHHHHH		44.1027251275
354PhosphorylationSYLGPPLTPEKDDAL
HHCCCCCCCCCCCHH		34.8628348404
382PhosphorylationMSKNSLLSLKADVLG
HCCCCHHHHCCEEEC		32.8724719451
441PhosphorylationKRHMRSHTGERPYPC
HHHHHHCCCCCCCCC		41.8228555341
485PhosphorylationVCSRVFMSAASVGIR
HHHHHHHHHHHHCCC		14.8230631047
495PhosphorylationSVGIRHGSRRHGVCT
HHCCCCCCCCCCCCC		21.7330631047
576PhosphorylationEDSPRPRSPPGGPDK
CCCCCCCCCCCCCCC		37.8223663014
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZBT46_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZBT46_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZBT46_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DESI1_HUMANDESI1physical
22370726
EHMT1_HUMANEHMT1physical
26186194
PRP8_HUMANPRPF8physical
26186194
P66B_HUMANGATAD2Bphysical
26186194
P66A_HUMANGATAD2Aphysical
26186194
MBD3_HUMANMBD3physical
26186194
MTA1_HUMANMTA1physical
26186194
AP2A1_HUMANAP2A1physical
26186194
AP2A2_HUMANAP2A2physical
26186194
RGPD5_HUMANRGPD5physical
26186194
DDX23_HUMANDDX23physical
26186194
ZBT10_HUMANZBTB10physical
26186194
EHMT2_HUMANEHMT2physical
26186194
FXL17_HUMANFBXL17physical
26186194
FBW1A_HUMANBTRCphysical
26186194
FBW1B_HUMANFBXW11physical
26186194
ZN318_HUMANZNF318physical
26186194
WIZ_HUMANWIZphysical
26186194
SUFU_HUMANSUFUphysical
26186194
FBX21_HUMANFBXO21physical
26186194
ZBT10_HUMANZBTB10physical
28514442
FXL17_HUMANFBXL17physical
28514442
EHMT1_HUMANEHMT1physical
28514442
P66B_HUMANGATAD2Bphysical
28514442
EHMT2_HUMANEHMT2physical
28514442
P66A_HUMANGATAD2Aphysical
28514442
AP2A2_HUMANAP2A2physical
28514442
AP2A1_HUMANAP2A1physical
28514442
FBW1A_HUMANBTRCphysical
28514442
WIZ_HUMANWIZphysical
28514442
MBD3_HUMANMBD3physical
28514442
MTA1_HUMANMTA1physical
28514442
FBW1B_HUMANFBXW11physical
28514442
U520_HUMANSNRNP200physical
28514442
SUFU_HUMANSUFUphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZBT46_HUMAN

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Related Literatures of Post-Translational Modification

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