GBRB1_HUMAN - dbPTM
GBRB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GBRB1_HUMAN
UniProt AC P18505
Protein Name Gamma-aminobutyric acid receptor subunit beta-1
Gene Name GABRB1
Organism Homo sapiens (Human).
Sequence Length 474
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein .
Protein Description Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
Protein Sequence MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationTMVCCAHSTNEPSNM
EEEHHHCCCCCCCCC		17.8825954137
28PhosphorylationMVCCAHSTNEPSNMS
EEHHHCCCCCCCCCH		33.4625954137
35PhosphorylationTNEPSNMSYVKETVD
CCCCCCCHHHHHHHH		30.9023663014
36PhosphorylationNEPSNMSYVKETVDR
CCCCCCHHHHHHHHH		12.5525954137
46UbiquitinationETVDRLLKGYDIRLR
HHHHHHHCCCCEEEC		61.08-
46UbiquitinationETVDRLLKGYDIRLR
HHHHHHHCCCCEEEC		61.081737026
85PhosphorylationVNMDYTLTMYFQQSW
ECCCEEEEEEEEHHH		11.30-
105N-linked_GlycosylationSYSGIPLNLTLDNRV
EECCCCCEEEECCCH		26.14UniProtKB CARBOHYD
127UbiquitinationDTYFLNDKKSFVHGV
CEEECCCCCCEEEEE		49.60-
128UbiquitinationTYFLNDKKSFVHGVT
EEECCCCCCEEEEEE		52.57-
137UbiquitinationFVHGVTVKNRMIRLH
EEEEEEECCCEEEEC		29.48-
158PhosphorylationYGLRITTTAACMMDL
EEEEEEHHHHHHHHH		12.0124260401
174N-linked_GlycosylationRYPLDEQNCTLEIES
CCCCCCCCCEEEEEE		20.77UniProtKB CARBOHYD
236PhosphorylationAYPRLSLSFRLKRNI
CCCCEEEEEEEHHHE		12.6324719451
309PhosphorylationYVKAIDIYLMGCFVF
HHHHHHHHHHHHHHH		6.21-
324PhosphorylationVFLALLEYAFVNYIF
HHHHHHHHHHHHHHH		12.81-
385PhosphorylationTSGSEVLTSVSDPKA
CCCCCEEEECCCCCC		32.0525690035
386PhosphorylationSGSEVLTSVSDPKAT
CCCCEEEECCCCCCE		18.5725690035
393PhosphorylationSVSDPKATMYSYDSA
ECCCCCCEEEEECCC		23.8324043423
395PhosphorylationSDPKATMYSYDSASI
CCCCCEEEEECCCCC		10.3424043423
396PhosphorylationDPKATMYSYDSASIQ
CCCCEEEEECCCCCE		16.1924043423
397PhosphorylationPKATMYSYDSASIQY
CCCEEEEECCCCCEE		9.0924043423
399PhosphorylationATMYSYDSASIQYRK
CEEEEECCCCCEECC		18.7124043423
401PhosphorylationMYSYDSASIQYRKPL
EEEECCCCCEECCCC		17.7424043423
404PhosphorylationYDSASIQYRKPLSSR
ECCCCCEECCCCCCH		20.9524043423
409PhosphorylationIQYRKPLSSREAYGR
CEECCCCCCHHHHHH		35.5610195104
434PhosphorylationGRIRRRASQLKVKIP
HHHHHHHHHCCCCCC		33.951321150
448PhosphorylationPDLTDVNSIDKWSRM
CCCCCCCCHHHHHHH		31.8217924679
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
434SPhosphorylationKinasePKA-FAMILY-GPS
434SPhosphorylationKinasePKC-FAMILY-GPS
434SPhosphorylationKinasePKA_GROUP-PhosphoELM
434SPhosphorylationKinasePKC_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GBRB1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GBRB1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOD1_HUMANNOD1physical
21988832
NDF4_HUMANNEUROD4physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00058 Gamma-Aminobutyric acid (JAN); Gammalon (TN)
D00225 Alprazolam (JP16/USP/INN); Xanax (TN)
D00267 Chlordiazepoxide (JP16/USP/INN); Libritabs (TN)
D00280 Clonazepam (JP16/USP/INN); Klonopin (TN)
D00293 Diazepam (JP16/USP/INN); Diastat (TN); Valium (TN)
D00311 Estazolam (JP16/USAN/INN); ProSom (TN)
D00329 Flurazepam (JAN/INN); Insumin (TN)
D00365 Lorazepam (JP16/USP/INN); Ativan (TN)
D00370 Temazepam (USP/INN); Restoril (TN)
D00376 Meprobamate (JAN/USP/INN); Equanil (TN); Miltown (TN)
D00387 Triazolam (JAN/USP/INN); Halcion (TN)
D00430 Secobarbital (USP/INN); Seconal (TN)
D00457 Quazepam (JAN/USP/INN); Doral (TN)
D00470 Prazepam (JP16/USAN/INN); Centrax (TN)
D00499 Pentobarbital (USP/INN); Nembutal (TN)
D00500 Pentobarbital sodium (JAN/USP); Nembutal sodium (TN)
D00506 Phenobarbital (JP16/USP/INN); Luminal (TN)
D00531 Nitrazepam (JP16/USAN/INN); Benzalin (TN); Nitrazepam (TN)
D00532 Glutethimide (JAN/INN); Doriden (TN)
D00549 Propofol (JAN/USAN/INN); Diprivan (TN)
D00550 Midazolam (JAN/USP/INN); Dormicum (TN); Buccolam (TN)
D00555 Amobarbital (JP16/INN); Isomytal (TN)
D00557 Methaqualone (JAN/USAN/INN)
D00693 Chlordiazepoxide hydrochloride (JAN/USP); Librium (TN)
D00694 Clorazepate dipotassium (JP16/USP); Tranxene (TN)
D00695 Flurazepam hydrochloride (USP); Flurazepam dihydrochloride; Dalmane (TN)
D00696 Midazolam hydrochloride (USAN); Versed (TN)
D00697 Flumazenil (JAN/USP/INN); Romazicon (TN)
D00700 Mephobarbital (JAN/USP); Methylphenobarbital (INN); Mebaral (TN)
D00701 Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN)
D00706 Zolpidem tartrate (JP16/USAN); Ambien (TN); Intermezzo (TN)
D00713 Thiamylal sodium (JP16); Surital (TN)
D00714 Thiopental sodium (JP16/USP/INN); Pentothal (TN)
D01071 Hexobarbital (JAN/INN)
D01230 Flunitrazepam (JP16/USAN/INN); Rohypnol (TN)
D01245 Bromazepam (JP16/USAN/INN); Lectopam (TN)
D01253 Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN)
D01254 Tofisopam (JP16/INN); Emandaxin (TN)
D01268 Cloxazolam (JP16/INN); Sepazon (TN)
D01278 Oxazolam (JP16/INN); Serenal (TN)
D01279 Flutoprazepam (JP16/INN); Restas (TN)
D01286 Flutazolam (JAN/INN); Coreminal (TN)
D01292 Medazepam (JP16/INN); Pamnace (TN)
D01293 Ethyl loflazepate (JAN/INN); Meilax (TN)
D01310 Secobarbital sodium (JAN/USP); Seconal sodium (TN)
D01316 Mexazolam (JAN/INN); Melex (TN)
D01328 Clotiazepam (JP16/INN); Rize (TN)
D01354 Fludiazepam (JP16/INN); Erispan (TN)
D01372 Zopiclone (JAN/INN); Amoban (TN); Zopiclone (TN)
D01408 Flurazepam hydrochloride (JP16); Flurazepam monohydrochloride; Dalmate (TN)
D01514 Etizolam (JP16/INN); Sedekopan (TN)
D01564 Rilmazafone hydrochloride hydrate (JAN); Rilmazafone hydrochloride dihydrate; Rilmazafone hydrochlor
D01593 Nimetazepam (JAN/INN); Erimin (TN)
D01657 Lormetazepam (JAN/USAN/INN); Loramet (TN)
D01740 Barbital (JP16/INN); Barbital (TN)
D01744 Brotizolam (JP16/USAN/INN); Lendormin (TN)
D01758 Haloxazolam (JP16/INN); Somelin (TN)
D02252 Amobarbital sodium (JAN/USP); Amytal sodium (TN)
D02253 Pentobarbital calcium (JP16); Ravona (TN)
D02283 Iomazenil (123I) (JAN/INN); Benzodine (TN)
D02594 Abecarnil (INN)
D02616 Pagoclone (USAN/INN); Bextra (TN)
D02617 Ocinaplon (USAN/INN)
D02624 Eszopiclone (JAN/USAN/INN); Estorra (TN); Lunesta (TN)
D02833 Alpidem (USAN/INN)
D03155 Bretazenil (USAN/INN)
D03562 Clorazepate monopotassium (USAN)
D03737 Dextofisopam (USAN/INN)
D04257 Fospropofol disodium (USAN); Aquavan (TN); Lusedra (TN)
D04282 Gaboxadol (USAN/INN)
D04300 Ganaxolone (USAN/INN)
D04721 Levotofisopam (USAN/INN)
D04882 Medazepam hydrochloride (USAN); Nobrium (TN)
D05028 Midazolam maleate (USAN)
D06106 Thiamylal
D07326 Loprazolam (INN); Dormonoct (TN)
D07409 Pentetrazol (INN); Pentylenetetrazol; Coryvet [veterinary] (TN)
D07784 Delorazepam (INN); Dadumir (TN)
D08145 Loprazolam mesilate; Loprazolam mesylate; Loprazolam methanesulfonate; Havlane (TN)
D08283 Nordazepam (INN); Calmday (TN)
D08356 Phenobarbital diethylamine; Gratusminal (TN)
D08481 Rilmazafone (INN)
D08507 Sarmazenil (INN); Sarmazol [veterinary] (TN)
D08690 Zolpidem (INN); Sanval (TN)
D08840 Adipiplon (USAN)
D10194 Remimazolam besilate (JAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GBRB1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, AND MASSSPECTROMETRY.

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