BZLF1_EBVB9 - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BZLF1_EBVB9
• UniProt AC: P03206
• Protein Name: Trans-activator protein BZLF1
• Gene Name: BZLF1
• Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
• Sequence Length: 245
• Subcellular Localization: Host nucleus .
• Protein Description: Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1)..
• Protein Sequence: MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAPQPGDNSTVQTAAAVVFACPGANQGQQLADIGVPQPAPVAAPARRTRKPQQPESLEECDSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Sumoylation	NSTSEDVKFTPDPYQ CCCCCCCCCCCCCCC	56.70	-
189	S-nitrosocysteine	NRVASRKCRAKFKQL HHHHHHHHHHHHHHH	5.06	-
189	S-nitrosylation	NRVASRKCRAKFKQL HHHHHHHHHHHHHHH	5.06	22178444

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
14	T	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
159	T	Phosphorylation	Kinase	PRKCA	-	GPS
167	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
173	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
186	S	Phosphorylation	Kinase	PRKCA	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BZLF1_EBVB9 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BZLF1_EBVB9 !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	28715492
CUL2_HUMAN	CUL2	physical	28715492
CAND1_HUMAN	CAND1	physical	28715492

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.