TRIB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIB2_HUMAN
• UniProt AC: Q92519
• Protein Name: Tribbles homolog 2
• Gene Name: TRIB2 {ECO:0000312|HGNC:HGNC:30809}
• Organism: Homo sapiens (Human).
• Sequence Length: 343
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. May associate with the cytoskeleton..
• Protein Description: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity)..
• Protein Sequence: MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	TPITIARYGRSRNKT CCEEHHHCCCCCCCC	14.10	22817900
20	Ubiquitination	RYGRSRNKTQDFEEL HCCCCCCCCCCHHHH	46.59	29967540
28	Phosphorylation	TQDFEELSSIRSAEP CCCHHHHHHHHCCCC	27.31	30301811
29	Phosphorylation	QDFEELSSIRSAEPS CCHHHHHHHHCCCCC	34.35	25954137
83	Phosphorylation	FRAVHLHSGEELVCK EEEEECCCCCEEEEE	55.02	-
133	Phosphorylation	AYVFFERSYGDMHSF EEEEEECCHHHHHHH	26.69	-
134	Phosphorylation	YVFFERSYGDMHSFV EEEEECCHHHHHHHH	24.30	-
139	Phosphorylation	RSYGDMHSFVRTCKK CCHHHHHHHHHHHHH	20.85	-
143	Phosphorylation	DMHSFVRTCKKLREE HHHHHHHHHHHHCHH	24.31	-
192	Ubiquitination	DEERTRVKLESLEDA CCCCCCEEEEHHHCE	43.15	29967540
200	Phosphorylation	LESLEDAYILRGDDD EEHHHCEEEECCCCC	16.89	29759185
218	Phosphorylation	DKHGCPAYVSPEILN CCCCCCCCCCHHHHC	6.13	22617229
229	Phosphorylation	EILNTSGSYSGKAAD HHHCCCCCCCCHHHH	18.85	22617229
245	Phosphorylation	WSLGVMLYTMLVGRY HHHHHHHHHHHHCCC	3.36	26503514
264	Phosphorylation	IEPSSLFSKIRRGQF CCHHHHHHHHHCCCC	32.25	24719451
278	Phosphorylation	FNIPETLSPKAKCLI CCCCCCCCHHHHHHH	31.60	24719451
298	Phosphorylation	REPSERLTSQEILDH CCCCCCCCCHHHHCC	34.29	-
299	Phosphorylation	EPSERLTSQEILDHP CCCCCCCCHHHHCCC	30.33	30576142
315	Phosphorylation	FSTDFSVSNSAYGAK CCCCCCCCCCCCCCH	24.70	30576142
317	Phosphorylation	TDFSVSNSAYGAKEV CCCCCCCCCCCCHHH	18.50	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
83	S	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:24089522
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24211582

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
FBW1A_HUMAN	BTRC	physical	23769673
SMUF1_HUMAN	SMURF1	physical	24089522
KS6B1_HUMAN	RPS6KB1	physical	24089522
ANM6_HUMAN	PRMT6	physical	23455924
RFWD2_HUMAN	RFWD2	physical	25311538
FBW1A_HUMAN	BTRC	physical	25311538
SMUF1_HUMAN	SMURF1	physical	25311538
DET1_HUMAN	DET1	physical	28514442
STK40_HUMAN	STK40	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442
GSTA4_HUMAN	GSTA4	physical	28514442
KCD21_HUMAN	KCTD21	physical	28514442
ISCA1_HUMAN	ISCA1	physical	28514442
SKT_HUMAN	KIAA1217	physical	28514442
TRIB1_HUMAN	TRIB1	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
UB2E1_HUMAN	UBE2E1	physical	28514442
BDH2_HUMAN	BDH2	physical	28514442
RPTOR_HUMAN	RPTOR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.