dbPTM

KMT2E_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KMT2E_HUMAN
UniProt AC	Q8IZD2
Protein Name	Inactive histone-lysine N-methyltransferase 2E {ECO:0000305}
Gene Name	KMT2E
Organism	Homo sapiens (Human).
Sequence Length	1858
Subcellular Localization	Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus speckle . Absent from the nucleolus (PubMed:14718661). Localizes to chromosome during interphase and to centrosomes during mitosis (PubMed:23798402). Dissociati
Protein Description	Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. [PubMed: 23629655]
Protein Sequence	MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMENINSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDNLIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Phosphorylation	------MSIVIPLGV ------CCEEEECCC	23401153
11	Phosphorylation	VIPLGVDTAETSYLE EEECCCCCCCHHHHH	23401153
14	Phosphorylation	LGVDTAETSYLEMAA CCCCCCCHHHHHHHC	23401153
15	O-linked_Glycosylation	GVDTAETSYLEMAAG CCCCCCHHHHHHHCC	30379171
15	Phosphorylation	GVDTAETSYLEMAAG CCCCCCHHHHHHHCC	28348404
16	Phosphorylation	VDTAETSYLEMAAGS CCCCCHHHHHHHCCC	28348404
23	Phosphorylation	YLEMAAGSEPESVEA HHHHHCCCCCCCCCC	21815630
27	Phosphorylation	AAGSEPESVEASPVV HCCCCCCCCCCCCEE	23401153
41	Phosphorylation	VVEKSNSYPHQLYTS EEECCCCCCCCCEEC	-
47	Phosphorylation	SYPHQLYTSSSHHSH CCCCCCEECCCCCCC	-
48	Phosphorylation	YPHQLYTSSSHHSHS CCCCCEECCCCCCCC	-
100	O-linked_Glycosylation	TTPNFDETSSATTIS ECCCCCCCCCCEEEE	30379171
185	O-linked_Glycosylation	RRKRENMSDGDTSAT HHHHHCCCCCCCCCC	30379171
185	Phosphorylation	RRKRENMSDGDTSAT HHHHHCCCCCCCCCC	22210691
189	O-linked_Glycosylation	ENMSDGDTSATESGD HCCCCCCCCCCCCCC	30379171
214	Phosphorylation	QHTPTSITLTASRVS CCCCCEEEEEHHHHH	-
221	Phosphorylation	TLTASRVSKVNDKRR EEEHHHHHHCCHHHH	22210691
252	O-linked_Glycosylation	FREGSRKSSRVKGSA HHHCCCCCCCCCCCC	30379171
256	Ubiquitination	SRKSSRVKGSAPEID CCCCCCCCCCCCCCC	29967540
258	O-linked_Glycosylation	KSSRVKGSAPEIDPS CCCCCCCCCCCCCCC	30379171
265	Phosphorylation	SAPEIDPSSDGSNFG CCCCCCCCCCCCCCC	27732954
266	Phosphorylation	APEIDPSSDGSNFGW CCCCCCCCCCCCCCH	27732954
269	Phosphorylation	IDPSSDGSNFGWETK CCCCCCCCCCCHHHH	24247654
275	Phosphorylation	GSNFGWETKIKAWMD CCCCCHHHHHHHHHH	27732954
276	Ubiquitination	SNFGWETKIKAWMDR CCCCHHHHHHHHHHH	29967540
435	O-linked_Glycosylation	LYIYSIHSIPKGTEI EEEEEEECCCCCCEE	30379171
440	O-linked_Glycosylation	IHSIPKGTEITIAFD EECCCCCCEEEEEEE	26678539
472	Ubiquitination	NPECPVLKRSSESME CCCCCCEECCHHHHH	29967540
475	O-linked_Glycosylation	CPVLKRSSESMENIN CCCEECCHHHHHHHH	30379171
485	Phosphorylation	MENINSGYETRRKKG HHHHHHHHHHHHHCC	30576142
487	Phosphorylation	NINSGYETRRKKGKK HHHHHHHHHHHCCCC	-
499	Phosphorylation	GKKDKDISKEKDTQN CCCCCCCCCCCCCCC	30576142
510	Phosphorylation	DTQNQNITLDCEGTT CCCCCCEEEECCCCC	28555341
531	O-linked_Glycosylation	ETKQRKLSPLRLSVS HHHCCCCCCCEEECC	30379171
531	Phosphorylation	ETKQRKLSPLRLSVS HHHCCCCCCCEEECC	30278072
536	O-linked_Glycosylation	KLSPLRLSVSNNQEP CCCCCEEECCCCCCC	30379171
536	Phosphorylation	KLSPLRLSVSNNQEP CCCCCEEECCCCCCC	24719451
538	O-linked_Glycosylation	SPLRLSVSNNQEPDF CCCEEECCCCCCCCC	30379171
538	Phosphorylation	SPLRLSVSNNQEPDF CCCEEECCCCCCCCC	24719451
553	Phosphorylation	IDDIEEKTPISNEVE HHHHHHHCCCCCCCH	29083192
556	Phosphorylation	IEEKTPISNEVEMES HHHHCCCCCCCHHHC	29083192
563	Phosphorylation	SNEVEMESEEQIAER CCCCHHHCHHHHHHH	29083192
610	Phosphorylation	ERISTAKTEVKTECK HHHHHCCHHCCCCCC	24275569
614	Phosphorylation	TAKTEVKTECKDTQI HCCHHCCCCCCCCEE	27690223
619	Phosphorylation	VKTECKDTQIVSDAE CCCCCCCCEECCHHH	25159151
623	Phosphorylation	CKDTQIVSDAEVIQE CCCCEECCHHHHHHH	30266825
638	Phosphorylation	QAKEENASKPTPAKV HHHHHCCCCCCCCCC	23403867
641	Phosphorylation	EENASKPTPAKVNRT HHCCCCCCCCCCCCH	23403867
653	Phosphorylation	NRTKQRKSFSRSRTH CCHHHCCCCCCCCCH	20363803
655	Phosphorylation	TKQRKSFSRSRTHIG HHHCCCCCCCCCHHH	20363803
657	Phosphorylation	QRKSFSRSRTHIGQQ HCCCCCCCCCHHHHH	20363803
748	Ubiquitination	EKNEKTGKPSDGLSE HHHHCCCCCCCCCCC	29967540
778	Phosphorylation	LNSLPGLTYSPHVYS HHCCCCCCCCCCCCC	28348404
779	Phosphorylation	NSLPGLTYSPHVYST HCCCCCCCCCCCCCC	28348404
780	Phosphorylation	SLPGLTYSPHVYSTP CCCCCCCCCCCCCCC	21712546
784	Phosphorylation	LTYSPHVYSTPKHYI CCCCCCCCCCCCHHH	21712546
785	Phosphorylation	TYSPHVYSTPKHYIR CCCCCCCCCCCHHHE	28348404
786	Phosphorylation	YSPHVYSTPKHYIRF CCCCCCCCCCHHHEE	22817900
792	Methylation	STPKHYIRFTSPFLS CCCCHHHEECCHHHC	115483557
795	Phosphorylation	KHYIRFTSPFLSEKR CHHHEECCHHHCHHH	22199227
799	Phosphorylation	RFTSPFLSEKRRRKE EECCHHHCHHHCCCC	22199227
829	Phosphorylation	QALEEENSAILHRFN HHHHHHHHHHHHHCC	28555341
837	Phosphorylation	AILHRFNSPCQERSR HHHHHCCCCHHHCCC	23401153
843	Phosphorylation	NSPCQERSRSPAVNG CCCHHHCCCCCCCCC	26657352
845	Phosphorylation	PCQERSRSPAVNGEN CHHHCCCCCCCCCCC	21955146
854	Phosphorylation	AVNGENKSPLLLNDS CCCCCCCCCCCCCCC	25159151
861	Phosphorylation	SPLLLNDSCSLPDLT CCCCCCCCCCCCCCC	26657352
863	Phosphorylation	LLLNDSCSLPDLTTP CCCCCCCCCCCCCCH	26657352
868	Phosphorylation	SCSLPDLTTPLKKRR CCCCCCCCCHHHHHH	29978859
869	Phosphorylation	CSLPDLTTPLKKRRF CCCCCCCCHHHHHHH	29978859
882	Phosphorylation	RFYQLLDSVYSETST HHHHHHHHHHCCCCC	23401153
885	Phosphorylation	QLLDSVYSETSTPTP HHHHHHHCCCCCCCC	23401153
887	Phosphorylation	LDSVYSETSTPTPSP HHHHHCCCCCCCCCC	23401153
888	Phosphorylation	DSVYSETSTPTPSPY HHHHCCCCCCCCCCC	27080861
889	Phosphorylation	SVYSETSTPTPSPYA HHHCCCCCCCCCCCC	27080861
891	Phosphorylation	YSETSTPTPSPYATP HCCCCCCCCCCCCCC	27080861
893	Phosphorylation	ETSTPTPSPYATPTH CCCCCCCCCCCCCCC	27080861
895	Phosphorylation	STPTPSPYATPTHTD CCCCCCCCCCCCCCC	27080861
897	Phosphorylation	PTPSPYATPTHTDIT CCCCCCCCCCCCCCC	27080861
899	Phosphorylation	PSPYATPTHTDITPM CCCCCCCCCCCCCCC	27080861
901	Phosphorylation	PYATPTHTDITPMDP CCCCCCCCCCCCCCH	27080861
904	Phosphorylation	TPTHTDITPMDPSFA CCCCCCCCCCCHHHC	27080861
909	Phosphorylation	DITPMDPSFATPPRI CCCCCCHHHCCCCCC	27080861
912	Phosphorylation	PMDPSFATPPRIKSD CCCHHHCCCCCCCCC	20439461
918	Phosphorylation	ATPPRIKSDDETCRN CCCCCCCCCCHHHCC	28985074
941	Phosphorylation	VTPVTPGTPGNTMHF CCCCCCCCCCCCCEE	22210691
945	Phosphorylation	TPGTPGNTMHFENIS CCCCCCCCCEECCCC	22210691
952	Phosphorylation	TMHFENISSPESSPE CCEECCCCCCCCCHH	22210691
965	Phosphorylation	PEIKRRTYSQEGYDR HHHHHHCCCCCCCCC	23312004
966	Phosphorylation	EIKRRTYSQEGYDRS HHHHHCCCCCCCCCC	28450419
997	Phosphorylation	LGLQEIKTIGYTSPR HHCEEEHHCCCCCCC	23186163
1000	Phosphorylation	QEIKTIGYTSPRSRT EEEHHCCCCCCCCCC	27732954
1001	O-linked_Glycosylation	EIKTIGYTSPRSRTE EEHHCCCCCCCCCCC	30379171
1001	Phosphorylation	EIKTIGYTSPRSRTE EEHHCCCCCCCCCCC	28985074
1002	O-linked_Glycosylation	IKTIGYTSPRSRTEV EHHCCCCCCCCCCCH	30379171
1002	Phosphorylation	IKTIGYTSPRSRTEV EHHCCCCCCCCCCCH	23911959
1005	Phosphorylation	IGYTSPRSRTEVNRQ CCCCCCCCCCCHHHC	26074081
1062	Phosphorylation	STHSGRGTMYSSWVK CCCCCCCCEEEEEEC	23312004
1064	Phosphorylation	HSGRGTMYSSWVKSP CCCCCCEEEEEECCC	23312004
1065	Phosphorylation	SGRGTMYSSWVKSPD CCCCCEEEEEECCCC	23312004
1066	Phosphorylation	GRGTMYSSWVKSPDR CCCCEEEEEECCCCC	23312004
1070	Phosphorylation	MYSSWVKSPDRTGVN EEEEEECCCCCCCCC	25159151
1074	Phosphorylation	WVKSPDRTGVNFSVN EECCCCCCCCCEEEC	28450419
1082	Phosphorylation	GVNFSVNSNLRDLTP CCCEEECCCCCCCCC	24247654
1088	Phosphorylation	NSNLRDLTPSHQLEV CCCCCCCCCCCCEEE	27050516
1090	Phosphorylation	NLRDLTPSHQLEVGG CCCCCCCCCCEEECC	28348404
1104	Phosphorylation	GGFRISESKCLMQDD CCEEECCCEEEECCC	23403867
1147	Phosphorylation	NLIDGNCTPQNPPQK CCCCCCCCCCCCCCH	28985074
1158	Phosphorylation	PPQKKKVSLLEYRKR CCCHHHCHHHHHHHH	28555341
1273	Phosphorylation	YQRALLLSDHRKDKD HHHHHHHHCCCCCCC	23186163
1281	Phosphorylation	DHRKDKDSGGESPCV CCCCCCCCCCCCCCC	30177828
1285	Phosphorylation	DKDSGGESPCVSCSP CCCCCCCCCCCCCCH	30576142
1289	Phosphorylation	GGESPCVSCSPSHVQ CCCCCCCCCCHHHHC	30576142
1291	Phosphorylation	ESPCVSCSPSHVQSS CCCCCCCCHHHHCCC	25159151
1293	Phosphorylation	PCVSCSPSHVQSSPS CCCCCCHHHHCCCCC	28348404
1297	Phosphorylation	CSPSHVQSSPSSHSN CCHHHHCCCCCCCCC	30576142
1298	Phosphorylation	SPSHVQSSPSSHSNH CHHHHCCCCCCCCCC	28348404
1300	Phosphorylation	SHVQSSPSSHSNHIP HHHCCCCCCCCCCCH	30177828
1301	Phosphorylation	HVQSSPSSHSNHIPQ HHCCCCCCCCCCCHH	30177828
1303	Phosphorylation	QSSPSSHSNHIPQLQ CCCCCCCCCCCHHHH	30177828
1340	Phosphorylation	TTTNECPSPDTSQNT CCCCCCCCCCCCCCC	30576142
1343	Phosphorylation	NECPSPDTSQNTCKS CCCCCCCCCCCCCCC	28348404
1344	Phosphorylation	ECPSPDTSQNTCKSP CCCCCCCCCCCCCCC	28348404
1347	Phosphorylation	SPDTSQNTCKSPPKM CCCCCCCCCCCCCCC	30576142
1350	Phosphorylation	TSQNTCKSPPKMSKP CCCCCCCCCCCCCCC	28348404
1355	Phosphorylation	CKSPPKMSKPGSPGS CCCCCCCCCCCCCCC	30266825
1359	Phosphorylation	PKMSKPGSPGSVIPA CCCCCCCCCCCCCCC	30266825
1362	Phosphorylation	SKPGSPGSVIPAQAH CCCCCCCCCCCCCCC	30266825
1405	Phosphorylation	ELQQKQLSNNNQALS HHHHHHHHCCCCHHH	17081983
1444	Phosphorylation	TKLHCPPSPHLENPP CCCCCCCCCCCCCCC	30266825
1466	Phosphorylation	PVQHGYLSPKPPSQQ CCCCCCCCCCCHHHH	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
861	S	Phosphorylation	Kinase	PLK1	P53350	PSP
912	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
435	S	Glycosylation	26678539
O-glycosylated at Ser-435 and Thr-440 in the SET domain by OGT which probably prevents KMT2E proteasomal-mediated degradation.
440	T	Glycosylation	26678539
O-glycosylated at Ser-435 and Thr-440 in the SET domain by OGT which probably prevents KMT2E proteasomal-mediated degradation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KMT2E_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	21423215
OGT1_HUMAN	OGT	physical	26678539
UBP7_HUMAN	USP7	physical	26678539
HCFC1_HUMAN	HCFC1	physical	26678539
ILF2_HUMAN	ILF2	physical	26678539
RBM39_HUMAN	RBM39	physical	26678539
DHX30_HUMAN	DHX30	physical	26678539
DDX18_HUMAN	DDX18	physical	26678539
TRI25_HUMAN	TRIM25	physical	26678539
TOP2A_HUMAN	TOP2A	physical	26678539
DDX50_HUMAN	DDX50	physical	26678539
ZN768_HUMAN	ZNF768	physical	26678539
TYY1_HUMAN	YY1	physical	26678539
RBBP4_HUMAN	RBBP4	physical	26678539
MCM3_HUMAN	MCM3	physical	26678539
HDAC1_HUMAN	HDAC1	physical	26678539
VPS4A_HUMAN	VPS4A	physical	26678539
GRWD1_HUMAN	GRWD1	physical	26678539
WDR6_HUMAN	WDR6	physical	26678539
DDX24_HUMAN	DDX24	physical	26678539
CD11B_HUMAN	CDK11B	physical	26678539
CDC7_HUMAN	CDC7	physical	26678539
SIN3A_HUMAN	SIN3A	physical	26678539
CDK2_HUMAN	CDK2	physical	26678539
UBP10_HUMAN	USP10	physical	26678539
IMA4_HUMAN	KPNA3	physical	26678539
WDR12_HUMAN	WDR12	physical	26678539
SMYD3_HUMAN	SMYD3	physical	26678539
SNUT1_HUMAN	SART1	physical	26678539
RBBP6_HUMAN	RBBP6	physical	26678539
TRAF6_HUMAN	TRAF6	physical	26678539

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KMT2E_HUMAN

Related Literatures of Post-Translational Modification

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