CSN7A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN7A_MOUSE
• UniProt AC: Q9CZ04
• Protein Name: COP9 signalosome complex subunit 7a
• Gene Name: Cops7a
• Organism: Mus musculus (Mouse).
• Sequence Length: 275
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)..
• Protein Sequence: MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTDAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPASGTNQRQPSKKASKGKGLRGSAKIWSKSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAEVKVTG ------CCCEEEECC	32.89	-
20	Ubiquitination	EQFLLLAKSAKGAAL HHHHHHHHHHHHHHH	51.41	22790023
20 (in isoform 2)	Ubiquitination	-	51.41	22790023
113	Phosphorylation	AKVKCIPYAVLLEAL HHCCHHHHHHHHHHH	6.88	-
199	Ubiquitination	VSRANQHKEQQLGLK HHHHHHHHHHHHHHH	47.67	22790023
199 (in isoform 2)	Ubiquitination	-	47.67	22790023
206 (in isoform 2)	Ubiquitination	-	38.06	22790023
206	Ubiquitination	KEQQLGLKQQIESEV HHHHHHHHHHHHHHH	38.06	22790023
217	Ubiquitination	ESEVANLKKTIKVTT HHHHHHHHHHHHHHH	47.91	27667366
221	Ubiquitination	ANLKKTIKVTTAAAA HHHHHHHHHHHHHHH	38.47	-
223	Phosphorylation	LKKTIKVTTAAAAAA HHHHHHHHHHHHHHH	13.00	25367039
224	Phosphorylation	KKTIKVTTAAAAAAT HHHHHHHHHHHHHHH	19.79	25367039
231	Phosphorylation	TAAAAAATSQDPEQH HHHHHHHHCCCHHHH	23.38	26643407
232	Phosphorylation	AAAAAATSQDPEQHL HHHHHHHCCCHHHHH	28.05	26643407
233	Ubiquitination	AAAAATSQDPEQHLT HHHHHHCCCHHHHHH	66.96	27667366
236	Ubiquitination	AATSQDPEQHLTELR HHHCCCHHHHHHHHH	59.94	27667366
240	Phosphorylation	QDPEQHLTELREPAS CCHHHHHHHHHCCCC	30.74	26643407
247	Phosphorylation	TELREPASGTNQRQP HHHHCCCCCCCCCCC	57.79	26643407
249	Phosphorylation	LREPASGTNQRQPSK HHCCCCCCCCCCCCC	26.19	26643407
255	Phosphorylation	GTNQRQPSKKASKGK CCCCCCCCCCCCCCC	38.15	26824392
255 (in isoform 2)	Phosphorylation	-	38.15	29514104
257	Acetylation	NQRQPSKKASKGKGL CCCCCCCCCCCCCCC	63.33	130503
260	Acetylation	QPSKKASKGKGLRGS CCCCCCCCCCCCCCC	70.29	130507
262	Acetylation	SKKASKGKGLRGSAK CCCCCCCCCCCCCCH	59.51	7611985
269	Ubiquitination	KGLRGSAKIWSKSN- CCCCCCCHHHCCCC-	46.54	27667366
274	Phosphorylation	SAKIWSKSN------ CCHHHCCCC------	42.11	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN7A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN7A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN7A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CSN7A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.