FBXW9_HUMAN - dbPTM
FBXW9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBXW9_HUMAN
UniProt AC Q5XUX1
Protein Name F-box/WD repeat-containing protein 9
Gene Name FBXW9
Organism Homo sapiens (Human).
Sequence Length 488
Subcellular Localization
Protein Description Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence MELPLGRCDDSRTWDDDSDPESETDPDAQAKAYVARVLSPPKSGLAFSRPSQLSTPAASPSASEPRAASRVSAVSEPGLLSLPPELLLEICSYLDARLVLHVLSRVCHALRDLVSDHVTWRLRALRRVRAPYPVVEEKNFDWPAACIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRDRMETRDALMGWGGPSRGSDIPPHRPITHEAGPALLKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MELPLGRC
-------CCCCCCCC		12.3122814378
11PhosphorylationPLGRCDDSRTWDDDS
CCCCCCCCCCCCCCC		20.5428450419
13PhosphorylationGRCDDSRTWDDDSDP
CCCCCCCCCCCCCCC		36.8830278072
18 (in isoform 3)Phosphorylation-63.1624719451
18PhosphorylationSRTWDDDSDPESETD
CCCCCCCCCCCCCCC		63.1623927012
22 (in isoform 3)Phosphorylation-51.7024719451
22PhosphorylationDDDSDPESETDPDAQ
CCCCCCCCCCCHHHH		51.7030278072
24PhosphorylationDSDPESETDPDAQAK
CCCCCCCCCHHHHHH		63.2123927012
39PhosphorylationAYVARVLSPPKSGLA
HHHHHHHCCCCCCCC		35.9828355574
39 (in isoform 3)Phosphorylation-35.9824719451
43PhosphorylationRVLSPPKSGLAFSRP
HHHCCCCCCCCCCCH		44.8323403867
48PhosphorylationPKSGLAFSRPSQLST
CCCCCCCCCHHHCCC		37.3623403867
48 (in isoform 3)Phosphorylation-37.3624719451
51PhosphorylationGLAFSRPSQLSTPAA
CCCCCCHHHCCCCCC		42.5222167270
52UbiquitinationLAFSRPSQLSTPAAS
CCCCCHHHCCCCCCC		41.9621890473
54PhosphorylationFSRPSQLSTPAASPS
CCCHHHCCCCCCCCC		25.3822167270
55 (in isoform 3)Phosphorylation-26.0724719451
55PhosphorylationSRPSQLSTPAASPSA
CCHHHCCCCCCCCCC		26.0723401153
57UbiquitinationPSQLSTPAASPSASE
HHHCCCCCCCCCCCC		22.2122817900
59 (in isoform 3)Phosphorylation-22.8424719451
59PhosphorylationQLSTPAASPSASEPR
HCCCCCCCCCCCCCH		22.8423401153
61PhosphorylationSTPAASPSASEPRAA
CCCCCCCCCCCCHHH		41.7622167270
63PhosphorylationPAASPSASEPRAASR
CCCCCCCCCCHHHHC		53.0922167270
86UbiquitinationLLSLPPELLLEICSY
HHCCCHHHHHHHHHH		9.0221963094
115PhosphorylationHALRDLVSDHVTWRL
HHHHHHHHHHHHHHH		29.3327499020
119PhosphorylationDLVSDHVTWRLRALR
HHHHHHHHHHHHHHH		11.0527499020
205 (in isoform 2)Ubiquitination-8.0821890473
215 (in isoform 3)Ubiquitination-33.2721890473
215 (in isoform 1)Ubiquitination-33.2721890473
215UbiquitinationESNQVLIKTLGTKRN
CCCEEEEEECCCCCC		33.2727667366
220UbiquitinationLIKTLGTKRNSTHEG
EEEECCCCCCCCCCC		48.0222817900
249UbiquitinationGSWDSTVKLWDMAAD
CCCCHHEEEEEECCC		43.9021963094
266PhosphorylationQFGEIKASSAVLCLS
CCCEEEHHHHHHHHH		17.52-
267PhosphorylationFGEIKASSAVLCLSY
CCEEEHHHHHHHHHH		27.53-
281PhosphorylationYLPDILVTGTYDKKV
HCCCEEEEEECCCCE		21.99-
283PhosphorylationPDILVTGTYDKKVTI
CCEEEEEECCCCEEE		21.12-
287UbiquitinationVTGTYDKKVTIYDPR
EEEECCCCEEEECHH		41.53-
331UbiquitinationEAGPALLKHQQLHSR
CCCHHHHHHCCHHCC		39.97-
352PhosphorylationADDRHIISGSEDHTL
ECCCEEECCCCCCEE		35.3522210691
358PhosphorylationISGSEDHTLVVVDRR
ECCCCCCEEEEEECC		33.3022210691
413PhosphorylationGCFQLIRSFDVGHSF
CCEEEEEEECCCCCC		20.85-
419PhosphorylationRSFDVGHSFPITGIQ
EEECCCCCCCCCCEE		27.13-
439UbiquitinationLYTTSTDKTIRVHVP
EEECCCCCEEEEECC		46.04-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBXW9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBXW9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBXW9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SKP1_HUMANSKP1physical
19159283
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBXW9_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; THR-55 AND SER-59,AND MASS SPECTROMETRY.

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