DDX43_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX43_HUMAN
• UniProt AC: Q9NXZ2
• Protein Name: Probable ATP-dependent RNA helicase DDX43
• Gene Name: DDX43
• Organism: Homo sapiens (Human).
• Sequence Length: 648
• Protein Sequence: MSHHGGAPKASTWVVASRRSSTVSRAPERRPAEELNRTGPEGYSVGRGGRWRGTSRPPEAVAAGHEELPLCFALKSHFVGAVIGRGGSKIKNIQSTTNTTIQIIQEQPESLVKIFGSKAMQTKAKAVIDNFVKKLEENYNSECGIDTAFQPSVGKDGSTDNNVVAGDRPLIDWDQIREEGLKWQKTKWADLPPIKKNFYKESTATSAMSKVEADSWRKENFNITWDDLKDGEKRPIPNPTCTFDDAFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRNRPGMLVLTPTRELALQVEGECCKYSYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAVSSVKQNIIVTTEEEKWSHMQTFLQSMSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAGRTGVSITTLTRNDWRVASELINILERANQSIPEELVSMAERFKAHQQKREMERKMERPQGRPKKFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHHGGAPK ------CCCCCCCCC	24.96	28060719
21	Phosphorylation	VVASRRSSTVSRAPE EEECCCCCCCCCCCC	30.89	24173317
22	Phosphorylation	VASRRSSTVSRAPER EECCCCCCCCCCCCC	24.60	26471730
24	Phosphorylation	SRRSSTVSRAPERRP CCCCCCCCCCCCCCC	23.86	22210691
47	Methylation	PEGYSVGRGGRWRGT CCCCCCCCCCCCCCC	42.09	-
85	Methylation	FVGAVIGRGGSKIKN HHHEEECCCCHHCCC	34.86	-
89	Ubiquitination	VIGRGGSKIKNIQST EECCCCHHCCCEECC	62.06	-
110	Phosphorylation	IIQEQPESLVKIFGS HHHHCCHHHHHHHCC	45.18	24275569
202	Phosphorylation	KKNFYKESTATSAMS CCCCCCCCCCCHHHH	21.13	-
203	Phosphorylation	KNFYKESTATSAMSK CCCCCCCCCCHHHHH	34.74	-
323	Phosphorylation	RPGMLVLTPTRELAL CCCEEEEECCHHHHH	18.35	24719451
339	Phosphorylation	VEGECCKYSYKGLRS EECCHHCCCCCCCCE	11.88	-
346	Phosphorylation	YSYKGLRSVCVYGGG CCCCCCCEEEEECCC	25.55	-
372	Phosphorylation	GVDIIIATPGRLNDL CCCEEEECCCCCCHH	18.83	-
544	Phosphorylation	KVRILIATDLASRGL CEEEEEECCHHHCCC	25.26	-
592	Phosphorylation	GVSITTLTRNDWRVA CEEEEEECCCCHHHH	25.90	22817900
619	Phosphorylation	SIPEELVSMAERFKA CCCHHHHHHHHHHHH	25.54	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX43_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX43_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX43_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KR103_HUMAN	KRTAP10-3	physical	25416956
HNRH1_HUMAN	HNRNPH1	physical	26344197
HNRH3_HUMAN	HNRNPH3	physical	26344197
DDX53_HUMAN	DDX53	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-592, AND MASSSPECTROMETRY.
PubMed: 18187866