DDX53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX53_HUMAN
• UniProt AC: Q86TM3
• Protein Name: Probable ATP-dependent RNA helicase DDX53
• Gene Name: DDX53
• Organism: Homo sapiens (Human).
• Sequence Length: 631
• Subcellular Localization: Nucleus .
• Protein Sequence: MSHWAPEWKRAEANPRDLGASWDVRGSRGSGWSGPFGHQGPRAAGSREPPLCFKIKNNMVGVVIGYSGSKIKDLQHSTNTKIQIINGESEAKVRIFGNREMKAKAKAAIETLIRKQESYNSESSVDNAASQTPIGRNLGRNDIVGEAEPLSNWDRIRAAVVECEKRKWADLPPVKKNFYIESKATSCMSEMQVINWRKENFNITCDDLKSGEKRLIPKPTCRFKDAFQQYPDLLKSIIRVGIVKPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLMPGFIHLDSQPISREQRNGPGMLVLTPTRELALHVEAECSKYSYKGLKSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDLQMNNSVNLRSITYLVIDEADKMLDMEFEPQIRKILLDVRPDRQTVMTSATWPDTVRQLALSYLKDPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRALTQEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNIKILITTDIVSRGLDLNDVTHVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLITQRDSKMAGELIKILDRANQSVPEDLVVMAEQYKLNQQKRHRETRSRKPGQRRKEFYFLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	NPRDLGASWDVRGSR CHHHCCCCEECCCCC	23.24	24850871
106	Ubiquitination	REMKAKAKAAIETLI HHHHHHHHHHHHHHH	37.33	-
185	Phosphorylation	FYIESKATSCMSEMQ EEECCCCCCHHCCCH	26.62	28270605
186	Phosphorylation	YIESKATSCMSEMQV EECCCCCCHHCCCHH	16.81	28270605
189	Phosphorylation	SKATSCMSEMQVINW CCCCCHHCCCHHHCC	33.95	28270605
303	Phosphorylation	GPGMLVLTPTRELAL CCCEEEECCCHHHHH	18.35	24719451
352	Phosphorylation	GVDIIIATPGRLNDL CCCEEEECCCCCCHH	18.83	-
407	Phosphorylation	DRQTVMTSATWPDTV CCCEECCCCCCCHHH	12.95	-
409	Phosphorylation	QTVMTSATWPDTVRQ CEECCCCCCCHHHHH	36.98	-
413	Phosphorylation	TSATWPDTVRQLALS CCCCCCHHHHHHHHH	17.32	-
420	Phosphorylation	TVRQLALSYLKDPMI HHHHHHHHHHCCCEE	23.86	23532336
485	Phosphorylation	HIADDLSSDFNIQGI HHHHHCCCCCCEECC	54.22	18452278
515	Phosphorylation	RAVEDFKSGNIKILI HHHHHHHHCCEEEEE	36.75	29449344
551	Phosphorylation	FPRNIDVYVHRVGYI CCCCEEEEEEEEEEE	6.18	-
557	Phosphorylation	VYVHRVGYIGRTGKT EEEEEEEEECCCCCC	9.42	27422710
561	Phosphorylation	RVGYIGRTGKTGTSV EEEEECCCCCCCCEE	37.50	23403867
563	Ubiquitination	GYIGRTGKTGTSVTL EEECCCCCCCCEEEE	43.07	22817900
564	Phosphorylation	YIGRTGKTGTSVTLI EECCCCCCCCEEEEE	47.22	23403867
566	Phosphorylation	GRTGKTGTSVTLITQ CCCCCCCCEEEEEEC	25.84	23403867
567	Phosphorylation	RTGKTGTSVTLITQR CCCCCCCEEEEEECC	17.91	23403867
569	Phosphorylation	GKTGTSVTLITQRDS CCCCCEEEEEECCCH	16.53	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX53_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX53_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPM1B_HUMAN	PPM1B	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.