UNC5B_HUMAN - dbPTM
UNC5B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UNC5B_HUMAN
UniProt AC Q8IZJ1
Protein Name Netrin receptor UNC5B
Gene Name UNC5B
Organism Homo sapiens (Human).
Sequence Length 945
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Membrane raft . Associated with lipid rafts.
Protein Description Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. [PubMed: 12598906 Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity]
Protein Sequence MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSLKVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41O-linked_GlycosylationVLPDSFPSAPAEPLP
CCCCCCCCCCCCCCC		44.89OGP
101UbiquitinationQEGLDEATGLRVREV
CCCHHHHHCCEEEEE		34.4023503661
139UbiquitinationAWSSAGTTKSRRAYV
EECCCCCCHHHHHHH		26.5522817900
220PhosphorylationRQARLSDTANYTCVA
ECCHHCCCCCCEEEE		17.2728152594
222N-linked_GlycosylationARLSDTANYTCVAKN
CHHCCCCCCEEEEEE		34.44UniProtKB CARBOHYD
223PhosphorylationRLSDTANYTCVAKNI
HHCCCCCCEEEEEEE		10.0728152594
224PhosphorylationLSDTANYTCVAKNIV
HCCCCCCEEEEEEEH		10.5828152594
341PhosphorylationGGRDCSGTLLDSKNC
CCCCCCCCCCCCCCC		14.09-
347N-linked_GlycosylationGTLLDSKNCTDGLCM
CCCCCCCCCCCCCCC		37.56UniProtKB CARBOHYD
403S-palmitoylationVVVYRRNCRDFDTDI
HHHCCCCCCCCCCCC		4.1318582460
411PhosphorylationRDFDTDITDSSAALT
CCCCCCCCCCHHHHH		32.4127732954
413PhosphorylationFDTDITDSSAALTGG
CCCCCCCCHHHHHCC		17.1527732954
414PhosphorylationDTDITDSSAALTGGF
CCCCCCCHHHHHCCC		21.9927732954
416 (in isoform 2)Ubiquitination-13.96-
416UbiquitinationDITDSSAALTGGFHP
CCCCCHHHHHCCCCC		13.9623503661
422UbiquitinationAALTGGFHPVNFKTA
HHHHCCCCCCCCCCC		28.7723503661
427UbiquitinationGFHPVNFKTARPSNP
CCCCCCCCCCCCCCC		35.7523503661
428PhosphorylationFHPVNFKTARPSNPQ
CCCCCCCCCCCCCCC		24.6224719451
452PhosphorylationLTASAGIYRGPVYAL
CCCCCCCCCCCEEEE		14.4825884760
454UbiquitinationASAGIYRGPVYALQD
CCCCCCCCCEEEECC		10.0722817900
454 (in isoform 2)Ubiquitination-10.0721906983
457PhosphorylationGIYRGPVYALQDSTD
CCCCCCEEEECCCCC		12.5321945579
460UbiquitinationRGPVYALQDSTDKIP
CCCEEEECCCCCCCC		34.1422817900
462PhosphorylationPVYALQDSTDKIPMT
CEEEECCCCCCCCCC		26.0821945579
463PhosphorylationVYALQDSTDKIPMTN
EEEECCCCCCCCCCC		49.9921945579
465 (in isoform 1)Ubiquitination-49.1221906983
465UbiquitinationALQDSTDKIPMTNSP
EECCCCCCCCCCCCC		49.1222817900
469PhosphorylationSTDKIPMTNSPLLDP
CCCCCCCCCCCCCCC		27.4727732954
471PhosphorylationDKIPMTNSPLLDPLP
CCCCCCCCCCCCCCC		14.0425159151
479PhosphorylationPLLDPLPSLKVKVYS
CCCCCCCCCEEEEEE		48.8024719451
511PhosphorylationGVLPPGTYPSDFARD
CCCCCCCCCCHHHCC		13.4725884760
526PhosphorylationTHFLHLRSASLGSQQ
CCEEEEEECCCCCHH		28.6828450419
528PhosphorylationFLHLRSASLGSQQLL
EEEEEECCCCCHHHH		34.2129743597
531PhosphorylationLRSASLGSQQLLGLP
EEECCCCCHHHHCCC		21.7522617229
581PhosphorylationQGKFYEMYLLINKAE
CCCEEEEEEEEECCC		6.09-
679PhosphorylationILLDQLGTYVFTGES
HHHHHCCCEEECCCC		25.7123312004
680PhosphorylationLLDQLGTYVFTGESY
HHHHCCCEEECCCCC		7.5623312004
683PhosphorylationQLGTYVFTGESYSRS
HCCCEEECCCCCCHH		29.9623312004
686PhosphorylationTYVFTGESYSRSAVK
CEEECCCCCCHHHHH		29.7423312004
687PhosphorylationYVFTGESYSRSAVKR
EEECCCCCCHHHHHH		12.1023312004
688PhosphorylationVFTGESYSRSAVKRL
EECCCCCCHHHHHHH		29.1023312004
690PhosphorylationTGESYSRSAVKRLQL
CCCCCCHHHHHHHHH		31.3223312004
711PhosphorylationLCTSLEYSLRVYCLE
HHHHHHEEEEEEECC		10.5824719451
733PhosphorylationEVLELERTLGGYLVE
HHHHHHHHHCCCCCC		22.0018452278
737PhosphorylationLERTLGGYLVEEPKP
HHHHHCCCCCCCCCC		13.0318452278
757PhosphorylationSYHNLRLSLHDLPHA
CCCCEEEEHHHCCCH		19.7526356563
768PhosphorylationLPHAHWRSKLLAKYQ
CCCHHHHHHHHHHHC		23.5926356563
800PhosphorylationTFTLERHSLASTELT
EEEEEECCCCCCEEE		31.67-
803PhosphorylationLERHSLASTELTCKI
EEECCCCCCEEEEEE		27.92-
804PhosphorylationERHSLASTELTCKIC
EECCCCCCEEEEEEE		29.43-
807PhosphorylationSLASTELTCKICVRQ
CCCCCEEEEEEEEEE		12.91-
835PhosphorylationLAETPAGSLDTLCSA
EEECCCCCHHHHCCC		25.7728348404
838PhosphorylationTPAGSLDTLCSAPGS
CCCCCHHHHCCCCCC		34.6528348404
841PhosphorylationGSLDTLCSAPGSTVT
CCHHHHCCCCCCEEE		40.3828348404
869PhosphorylationIRQKICNSLDAPNSR
HHHHHHHCCCCCCCC		24.1827732954
875PhosphorylationNSLDAPNSRGNDWRM
HCCCCCCCCCCHHHH		40.2727732954
892PhosphorylationQKLSMDRYLNYFATK
HHHCHHHHHHHHHCC		8.6025884760
895PhosphorylationSMDRYLNYFATKASP
CHHHHHHHHHCCCCC		7.6225884760
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UNC5B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UNC5B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UNC5B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
2AAB_HUMANPPP2R1Bphysical
21172653
DAPK1_HUMANDAPK1physical
21172653
CIP2A_HUMANKIAA1524physical
21172653
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UNC5B_HUMAN

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Related Literatures of Post-Translational Modification
Palmitoylation
ReferencePubMed
"Lipid raft localization and palmitoylation: identification of tworequirements for cell death induction by the tumor suppressorsUNC5H.";
Maisse C., Rossin A., Cahuzac N., Paradisi A., Klein C., Haillot M.L.,Herincs Z., Mehlen P., Hueber A.O.;
Exp. Cell Res. 314:2544-2552(2008).
Cited for: PALMITOYLATION AT CYS-403, SUBCELLULAR LOCATION, AND INTERACTION WITHDAPK1.

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