FGF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGF3_HUMAN
• UniProt AC: P11487
• Protein Name: Fibroblast growth factor 3
• Gene Name: FGF3
• Organism: Homo sapiens (Human).
• Sequence Length: 239
• Subcellular Localization: Secreted .
• Protein Description: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development..
• Protein Sequence: MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSLFLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEASAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Methylation	LRRDAGGRGGVYEHL CCCCCCCCCCHHHHC	37.46	-
44	Methylation	EHLGGAPRRRKLYCA HHCCCCCCCCCEEEE	50.96	-
45	Methylation	HLGGAPRRRKLYCAT HCCCCCCCCCEEEEE	38.74	-
49	Phosphorylation	APRRRKLYCATKYHL CCCCCCEEEEEEEEE	5.31	22210691
52	Phosphorylation	RRKLYCATKYHLQLH CCCEEEEEEEEEEEC	28.68	22210691
65	N-linked_Glycosylation	LHPSGRVNGSLENSA ECCCCCCCCCCCCCC	32.73	UniProtKB CARBOHYD
93	Phosphorylation	VAIRGLFSGRYLAMN EEEEHHHHCCEEEEC	27.66	22673903
96	Phosphorylation	RGLFSGRYLAMNKRG EHHHHCCEEEECCCC	11.44	22673903
136	Phosphorylation	YASRLYRTVSSTPGA HHHHHHHHHCCCCCC	15.93	-
138	Phosphorylation	SRLYRTVSSTPGARR HHHHHHHCCCCCCCC	28.07	-
139	Phosphorylation	RLYRTVSSTPGARRQ HHHHHHCCCCCCCCC	33.99	-
176	Phosphorylation	TRRTQKSSLFLPRVL CCCCCCCCCCHHHHH	30.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EBP2_HUMAN	EBNA1BP2	physical	11438656
RS2_HUMAN	RPS2	physical	16263090
XRN1_HUMAN	XRN1	physical	28514442
ANKH1_HUMAN	ANKHD1	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442
ZN100_HUMAN	ZNF100	physical	28514442
ZN593_HUMAN	ZNF593	physical	28514442
TMED4_HUMAN	TMED4	physical	28514442
NUCB1_HUMAN	NUCB1	physical	28514442
CARF_HUMAN	CDKN2AIP	physical	28514442
GTPBA_HUMAN	GTPBP10	physical	28514442
YTDC2_HUMAN	YTHDC2	physical	28514442
NPA1P_HUMAN	URB1	physical	28514442
TMED1_HUMAN	TMED1	physical	28514442
H2AX_HUMAN	H2AFX	physical	28514442
TDIF2_HUMAN	DNTTIP2	physical	28514442
PWP2_HUMAN	PWP2	physical	28514442
TMED9_HUMAN	TMED9	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
RRP5_HUMAN	PDCD11	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
DDX51_HUMAN	DDX51	physical	28514442
DUS11_HUMAN	DUSP11	physical	28514442
DHX57_HUMAN	DHX57	physical	28514442
NOC2L_HUMAN	NOC2L	physical	28514442
PATZ1_HUMAN	PATZ1	physical	28514442
CENPU_HUMAN	CENPU	physical	28514442
NOL8_HUMAN	NOL8	physical	28514442
ZN689_HUMAN	ZNF689	physical	28514442
DHX36_HUMAN	DHX36	physical	28514442
TSYL2_HUMAN	TSPYL2	physical	28514442
RLP24_HUMAN	RSL24D1	physical	28514442
WDR36_HUMAN	WDR36	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
DDX18_HUMAN	DDX18	physical	28514442
NOL10_HUMAN	NOL10	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
DDX52_HUMAN	DDX52	physical	28514442
SAS10_HUMAN	UTP3	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
URB2_HUMAN	URB2	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
F207A_HUMAN	FAM207A	physical	28514442
TMEDA_HUMAN	TMED10	physical	28514442
ZN574_HUMAN	ZNF574	physical	28514442
MPP10_HUMAN	MPHOSPH10	physical	28514442
RFC1_HUMAN	RFC1	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.