| UniProt ID | MMP27_HUMAN | |
|---|---|---|
| UniProt AC | Q9H306 | |
| Protein Name | Matrix metalloproteinase-27 | |
| Gene Name | MMP27 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 513 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein . Retained in the endoplasmic reticulum. |
|
| Protein Description | Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.. | |
| Protein Sequence | MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPGWRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKEPKNSSFGFDINKEKAHSGGIKILYHKSLSLFIFGIVHLLKNTSIYQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | N-linked_Glycosylation | NHLVQSKNRSLIDDK CEECCCCCCHHCHHH | 43.98 | 24548619 | |
| 73 | Phosphorylation | MQAFFGLTVTGKLDS HHHHHCEEEEEEECC | 19.19 | 30631047 | |
| 110 | N-linked_Glycosylation | LPGWRKYNLTYRIIN CCCHHHEEEEEEEEE | 29.01 | 24548619 | |
| 147 | Phosphorylation | KVTPLKFTKISKGIA HCCCCCCCCCCCCHH | 26.36 | - | |
| 151 | Acetylation | LKFTKISKGIADIMI CCCCCCCCCHHHHHH | 58.78 | 7851945 | |
| 258 | Phosphorylation | DDINGIQSIYGGLPK HHHCCHHHHHCCCCC | 18.83 | 25332170 | |
| 260 | Phosphorylation | INGIQSIYGGLPKEP HCCHHHHHCCCCCCC | 15.47 | 25332170 | |
| 307 | Phosphorylation | GRHLWRIYYDITDVE CCEEEEEEEECCCHH | 6.11 | - | |
| 333 | Phosphorylation | PADLQAAYENPRDKI CHHHHHHHHCCCCCE | 21.18 | - | |
| 360 | Phosphorylation | GYAVLPDYPKSIHTL EEEECCCCCCCEECC | 15.60 | - | |
| 452 | N-linked_Glycosylation | EYDIKTKNITRIMRT EEEEECCCEEEEEEE | 46.20 | 24548619 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MMP27_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MMP27_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MMP27_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MMP27_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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