| UniProt ID | SPB12_HUMAN | |
|---|---|---|
| UniProt AC | Q96P63 | |
| Protein Name | Serpin B12 | |
| Gene Name | SERPINB12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 405 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.. | |
| Protein Sequence | MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNESKEPDPCLKSNKQKAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MDSLVTANTK -----CCCCHHCCCH | 24.36 | 20068231 | |
| 6 | Phosphorylation | --MDSLVTANTKFCF --CCCCHHCCCHHHH | 21.34 | 20068231 | |
| 9 | Phosphorylation | DSLVTANTKFCFDLF CCCHHCCCHHHHHHH | 24.04 | 20068231 | |
| 34 | Phosphorylation | NIFFSPLSLSAALGM CCCCCCHHHHHHHHH | 24.54 | 19413330 | |
| 36 | Phosphorylation | FFSPLSLSAALGMVR CCCCHHHHHHHHHHH | 14.23 | 19413330 | |
| 84 | Phosphorylation | SNKQKAGSLNNESGL CCCCCCCCCCCCCCH | 32.55 | 22210691 | |
| 87 (in isoform 2) | Phosphorylation | - | 50.53 | 22617229 | |
| 89 | Phosphorylation | AGSLNNESGLVSCYF CCCCCCCCCHHHHHH | 39.28 | 22210691 | |
| 101 | Phosphorylation | CYFGQLLSKLDRIKT HHHHHHHHHHHHHCC | 39.50 | 24719451 | |
| 175 | Phosphorylation | GKIKELFSKDAINAE CCHHHHHCCCCCCHH | 42.10 | 24719451 | |
| 183 | Phosphorylation | KDAINAETVLVLVNA CCCCCHHHHHHHHHH | 19.41 | 28674151 | |
| 192 | Phosphorylation | LVLVNAVYFKAKWET HHHHHHHHHHHHHHC | 9.28 | 28674151 | |
| 247 | Phosphorylation | AQILEMRYTKGKLSM HHHHHHHCCCCCEEE | 16.11 | 29978859 | |
| 248 | Phosphorylation | QILEMRYTKGKLSMF HHHHHHCCCCCEEEE | 23.97 | 29978859 | |
| 298 | Phosphorylation | SEESVVLSFPRFTLE CCCEEEEECCCCCCC | 22.92 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPB12_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPB12_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPB12_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SPB12_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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