GLCI1_HUMAN - dbPTM
GLCI1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLCI1_HUMAN
UniProt AC Q86VQ1
Protein Name Glucocorticoid-induced transcript 1 protein
Gene Name GLCCI1
Organism Homo sapiens (Human).
Sequence Length 547
Subcellular Localization
Protein Description
Protein Sequence MSTASSSSSSSSSQTPHPPSQRMRRSAAGSPPAVAAAGSGNGAGGGGGVGCAPAAGAGRLLQPIRATVPYQLLRGSQHSPTRPPVAAAAASLGSLPGPGAARGPSPSSPTPPAAAAPAEQAPRAKGRPRRSPESHRRSSSPERRSPGSPVCRADKAKSQQVRTSSTIRRTSSLDTITGPYLTGQWPRDPHVHYPSCMKDKATQTPSCWAEEGAEKRSHQRSASWGSADQLKEQIAKLRQQLQRSKQSSRHSKEKDRQSPLHGNHITISHTQATGSRSVPMPLSNISVPKSSVSRVPCNVEGISPELEKVFIKENNGKEEVSKPLDIPDGRRAPLPAHYRSSSTRSIDTQTPSVQERSSSCSSHSPCVSPFCPPESQDGSPCSTEDLLYDRDKDSGSSSPLPKYASSPKPNNSYMFKREPPEGCERVKVFEEMASRQPISAPLFSCPDKNKVNFIPTGSAFCPVKLLGPLLPASDLMLKNSPNSGQSSALATLTVEQLSSRVSFTSLSDDTSTAGSMEASVQQPSQQQQLLQELQGEDHISAQNYVII
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSTASSSSS
------CCCCCCCCC		32.4528857561
5Phosphorylation---MSTASSSSSSSS
---CCCCCCCCCCCC		30.73-
7Phosphorylation-MSTASSSSSSSSSQ
-CCCCCCCCCCCCCC		31.57-
8PhosphorylationMSTASSSSSSSSSQT
CCCCCCCCCCCCCCC		35.87-
9PhosphorylationSTASSSSSSSSSQTP
CCCCCCCCCCCCCCC		35.87-
10PhosphorylationTASSSSSSSSSQTPH
CCCCCCCCCCCCCCC		35.8728857561
11PhosphorylationASSSSSSSSSQTPHP
CCCCCCCCCCCCCCC		35.6428857561
15PhosphorylationSSSSSSQTPHPPSQR
CCCCCCCCCCCCCHH		26.0523186163
20PhosphorylationSQTPHPPSQRMRRSA
CCCCCCCCHHHHHHH		34.5623401153
26PhosphorylationPSQRMRRSAAGSPPA
CCHHHHHHHCCCCCC		16.4723401153
30PhosphorylationMRRSAAGSPPAVAAA
HHHHHCCCCCCEEEC		24.0030175587
39PhosphorylationPAVAAAGSGNGAGGG
CCEEECCCCCCCCCC		25.1028102081
67PhosphorylationLLQPIRATVPYQLLR
HCCCHHCCCCHHHHC		16.5027251275
70PhosphorylationPIRATVPYQLLRGSQ
CHHCCCCHHHHCCCC		13.8827642862
74MethylationTVPYQLLRGSQHSPT
CCCHHHHCCCCCCCC		51.84-
76PhosphorylationPYQLLRGSQHSPTRP
CHHHHCCCCCCCCCC		20.4923401153
79PhosphorylationLLRGSQHSPTRPPVA
HHCCCCCCCCCCHHH		21.9623401153
81PhosphorylationRGSQHSPTRPPVAAA
CCCCCCCCCCHHHHH		59.8429255136
82MethylationGSQHSPTRPPVAAAA
CCCCCCCCCHHHHHH		36.59-
91PhosphorylationPVAAAAASLGSLPGP
HHHHHHHHHCCCCCC		28.6522167270
94PhosphorylationAAAASLGSLPGPGAA
HHHHHHCCCCCCCCC		36.3620068231
102MethylationLPGPGAARGPSPSSP
CCCCCCCCCCCCCCC		57.95-
105PhosphorylationPGAARGPSPSSPTPP
CCCCCCCCCCCCCCC		39.9929255136
107PhosphorylationAARGPSPSSPTPPAA
CCCCCCCCCCCCCCH		53.9729255136
108PhosphorylationARGPSPSSPTPPAAA
CCCCCCCCCCCCCHH		35.8629255136
110PhosphorylationGPSPSSPTPPAAAAP
CCCCCCCCCCCHHCC		43.8029255136
131PhosphorylationAKGRPRRSPESHRRS
CCCCCCCCHHHHCCC		34.0120068231
134PhosphorylationRPRRSPESHRRSSSP
CCCCCHHHHCCCCCC		26.1924144214
138PhosphorylationSPESHRRSSSPERRS
CHHHHCCCCCCCCCC		34.8130576142
139PhosphorylationPESHRRSSSPERRSP
HHHHCCCCCCCCCCC		48.3723090842
140PhosphorylationESHRRSSSPERRSPG
HHHCCCCCCCCCCCC		31.8430576142
145PhosphorylationSSSPERRSPGSPVCR
CCCCCCCCCCCCCCC		39.5723401153
148PhosphorylationPERRSPGSPVCRADK
CCCCCCCCCCCCHHH		19.9729255136
157MethylationVCRADKAKSQQVRTS
CCCHHHHHCCCCCCC		55.31-
158PhosphorylationCRADKAKSQQVRTSS
CCHHHHHCCCCCCCH		30.61-
164PhosphorylationKSQQVRTSSTIRRTS
HCCCCCCCHHCCCCC		18.2126074081
165PhosphorylationSQQVRTSSTIRRTSS
CCCCCCCHHCCCCCC		27.5226074081
166PhosphorylationQQVRTSSTIRRTSSL
CCCCCCHHCCCCCCC		20.4726074081
170PhosphorylationTSSTIRRTSSLDTIT
CCHHCCCCCCCCEEC		16.9023401153
171PhosphorylationSSTIRRTSSLDTITG
CHHCCCCCCCCEECC		27.3925159151
172PhosphorylationSTIRRTSSLDTITGP
HHCCCCCCCCEECCC		29.6525159151
175PhosphorylationRRTSSLDTITGPYLT
CCCCCCCEECCCCCC		26.2322617229
177PhosphorylationTSSLDTITGPYLTGQ
CCCCCEECCCCCCCC		33.9122617229
180PhosphorylationLDTITGPYLTGQWPR
CCEECCCCCCCCCCC		20.4526074081
182PhosphorylationTITGPYLTGQWPRDP
EECCCCCCCCCCCCC		22.8326074081
217PhosphorylationEEGAEKRSHQRSASW
HCCHHHHCCCCCCCC		34.7329514088
221PhosphorylationEKRSHQRSASWGSAD
HHHCCCCCCCCCCHH		21.7830266825
223PhosphorylationRSHQRSASWGSADQL
HCCCCCCCCCCHHHH		32.9619664994
226PhosphorylationQRSASWGSADQLKEQ
CCCCCCCCHHHHHHH		23.5530266825
258PhosphorylationSKEKDRQSPLHGNHI
HHHHHHCCCCCCCEE		30.2629255136
266PhosphorylationPLHGNHITISHTQAT
CCCCCEEEEECCCCC		14.6323927012
268PhosphorylationHGNHITISHTQATGS
CCCEEEEECCCCCCC		16.3123927012
270PhosphorylationNHITISHTQATGSRS
CEEEEECCCCCCCCC		17.0729978859
273PhosphorylationTISHTQATGSRSVPM
EEECCCCCCCCCCCC		26.3523927012
275PhosphorylationSHTQATGSRSVPMPL
ECCCCCCCCCCCCCC		19.6123927012
277PhosphorylationTQATGSRSVPMPLSN
CCCCCCCCCCCCCCC		32.0629978859
286PhosphorylationPMPLSNISVPKSSVS
CCCCCCCCCCHHHHC		36.3024719451
290PhosphorylationSNISVPKSSVSRVPC
CCCCCCHHHHCCCCC		29.8726074081
291PhosphorylationNISVPKSSVSRVPCN
CCCCCHHHHCCCCCC		30.1826074081
293PhosphorylationSVPKSSVSRVPCNVE
CCCHHHHCCCCCCCC		29.5226074081
303PhosphorylationPCNVEGISPELEKVF
CCCCCCCCHHHHEEE		24.1519664994
317AcetylationFIKENNGKEEVSKPL
EEECCCCCCCCCCCC		53.4719818719
321PhosphorylationNNGKEEVSKPLDIPD
CCCCCCCCCCCCCCC		31.6624719451
340PhosphorylationPLPAHYRSSSTRSID
CCCCCCCCCCCCCCC		22.8323663014
341PhosphorylationLPAHYRSSSTRSIDT
CCCCCCCCCCCCCCC		27.0823663014
342PhosphorylationPAHYRSSSTRSIDTQ
CCCCCCCCCCCCCCC		29.1423663014
343PhosphorylationAHYRSSSTRSIDTQT
CCCCCCCCCCCCCCC		30.3122115753
345PhosphorylationYRSSSTRSIDTQTPS
CCCCCCCCCCCCCCC		25.5519664994
348PhosphorylationSSTRSIDTQTPSVQE
CCCCCCCCCCCCHHH		32.4523927012
350PhosphorylationTRSIDTQTPSVQERS
CCCCCCCCCCHHHHC		21.4423401153
352PhosphorylationSIDTQTPSVQERSSS
CCCCCCCCHHHHCCC		39.5629255136
358PhosphorylationPSVQERSSSCSSHSP
CCHHHHCCCCCCCCC		41.4027080861
359PhosphorylationSVQERSSSCSSHSPC
CHHHHCCCCCCCCCC		21.1827080861
361PhosphorylationQERSSSCSSHSPCVS
HHHCCCCCCCCCCCC		32.7927080861
362PhosphorylationERSSSCSSHSPCVSP
HHCCCCCCCCCCCCC		32.1027080861
364PhosphorylationSSSCSSHSPCVSPFC
CCCCCCCCCCCCCCC		23.1827080861
368PhosphorylationSSHSPCVSPFCPPES
CCCCCCCCCCCCCCC		20.9827080861
379PhosphorylationPPESQDGSPCSTEDL
CCCCCCCCCCCHHHH		30.9027080861
394PhosphorylationLYDRDKDSGSSSPLP
CCCCCCCCCCCCCCC		46.4429255136
396PhosphorylationDRDKDSGSSSPLPKY
CCCCCCCCCCCCCCC		31.4329255136
397PhosphorylationRDKDSGSSSPLPKYA
CCCCCCCCCCCCCCC		39.2329255136
398PhosphorylationDKDSGSSSPLPKYAS
CCCCCCCCCCCCCCC		31.9529255136
403PhosphorylationSSSPLPKYASSPKPN
CCCCCCCCCCCCCCC		15.1322617229
405PhosphorylationSPLPKYASSPKPNNS
CCCCCCCCCCCCCCC		44.0523401153
406PhosphorylationPLPKYASSPKPNNSY
CCCCCCCCCCCCCCC		28.8623401153
412PhosphorylationSSPKPNNSYMFKREP
CCCCCCCCCCCCCCC		25.3122115753
413PhosphorylationSPKPNNSYMFKREPP
CCCCCCCCCCCCCCC		14.5430576142
427UbiquitinationPEGCERVKVFEEMAS
CCCCCHHHHHHHHHH		47.6429967540
480PhosphorylationSDLMLKNSPNSGQSS
HHHCCCCCCCCCCCC		24.7025159151
483PhosphorylationMLKNSPNSGQSSALA
CCCCCCCCCCCCHHE		41.4122199227
486PhosphorylationNSPNSGQSSALATLT
CCCCCCCCCHHEEEE		22.5422199227
487PhosphorylationSPNSGQSSALATLTV
CCCCCCCCHHEEEEH		21.2918669648
491PhosphorylationGQSSALATLTVEQLS
CCCCHHEEEEHHHHH		24.6620068231
493PhosphorylationSSALATLTVEQLSSR
CCHHEEEEHHHHHHC		20.0328985074
498PhosphorylationTLTVEQLSSRVSFTS
EEEHHHHHHCCEEEE		18.7828985074
499PhosphorylationLTVEQLSSRVSFTSL
EEHHHHHHCCEEEEC		45.3427080861
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLCI1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLCI1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLCI1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GLCI1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLCI1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-177 AND SER-345, ANDMASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; SER-107; SER-108;SER-221 AND SER-303, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; SER-108; THR-110;SER-172; THR-175 AND SER-345, AND MASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221; SER-223; SER-303AND SER-345, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, AND MASSSPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND MASSSPECTROMETRY.

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