BGAT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BGAT_HUMAN
• UniProt AC: P16442
• Protein Name: Histo-blood group ABO system transferase
• Gene Name: ABO
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
• Protein Description: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity..
• Protein Sequence: MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	VLRTLAGKPKCHALR HHHHHCCCCCCHHHH	35.38	-
46	Phosphorylation	PRSLMPGSLERGFCM CCCCCCCCCCCCEEE	22.61	22468782
65	Phosphorylation	PDHLQRVSLPRMVYP CCCCCCCCCCCCCCC	34.54	24719451
113	N-linked_Glycosylation	NEQFRLQNTTIGLTV CCCCCCCCCCCCHHH	43.72	UniProtKB CARBOHYD
163	Phosphorylation	PAAVPRVTLGTGRQL CCCCCEEEECCCCCE	22.28	28555341
171	Phosphorylation	LGTGRQLSVLEVRAY ECCCCCEEEEEHHHH	19.13	28555341
178	Phosphorylation	SVLEVRAYKRWQDVS EEEEHHHHHHHHCHH	7.19	28555341
202	Phosphorylation	FCERRFLSEVDYLVC HHHHHCCCCCCEEEE	32.63	26074081
206	Phosphorylation	RFLSEVDYLVCVDVD HCCCCCCEEEEEECC	13.25	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BGAT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BGAT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BGAT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRM2B_HUMAN	GRAMD3	physical	25416956
TMM79_HUMAN	TMEM79	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.