GRM2B_HUMAN - dbPTM
GRM2B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GRM2B_HUMAN
UniProt AC Q96HH9
Protein Name GRAM domain-containing protein 2B
Gene Name GRAMD2B
Organism Homo sapiens (Human).
Sequence Length 432
Subcellular Localization
Protein Description
Protein Sequence MTELQQDVEDTKPAKVLGKRESKLGSAHSEAENGVEEKKKACRSPTAQSPTPSVEADSPDQKKIISLWSKSSFDGASLASDKNDCKTESKNDPKTERKKSSSSSQYKANMHFHKLFLSVPTEEPLKQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLLKSVCGHLENTSVGNSPNPSSAENSFRADRPSSLPLDFNDEFSDLDGVVQQRRQDMEGYSSSGSQTPESENSRDFHATESQTVLNVSKGEAKPTRADAHVNRVPEGKAKSLPVQGLSETVGILHKVKSQKCPMLHHILIFYAIVVCALIISTFYMRYRINTLEEQLGLLTSIVDTHNTEQAAPSGLRSQVQFNVEVLCQELTANIVKLEKIQNNLQKLLENGD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MTELQQDV
-------CCCHHHHH
22814378
13 (in isoform 4)Phosphorylation-26657352
26PhosphorylationKRESKLGSAHSEAEN
CCHHHCCCCCHHHHH
29255136
29PhosphorylationSKLGSAHSEAENGVE
HHCCCCCHHHHHCHH
29255136
44PhosphorylationEKKKACRSPTAQSPT
HHHHHHCCCCCCCCC
30278072
46PhosphorylationKKACRSPTAQSPTPS
HHHHCCCCCCCCCCC
30278072
49PhosphorylationCRSPTAQSPTPSVEA
HCCCCCCCCCCCCCC
26657352
51PhosphorylationSPTAQSPTPSVEADS
CCCCCCCCCCCCCCC
23663014
53PhosphorylationTAQSPTPSVEADSPD
CCCCCCCCCCCCCCC
23663014
58PhosphorylationTPSVEADSPDQKKII
CCCCCCCCCCHHHHH
23663014
71PhosphorylationIISLWSKSSFDGASL
HHHHHHCCCCCCCHH
25159151
72PhosphorylationISLWSKSSFDGASLA
HHHHHCCCCCCCHHC
25159151
77PhosphorylationKSSFDGASLASDKND
CCCCCCCHHCCCCCC
29396449
79 (in isoform 2)Phosphorylation-25159151
80 (in isoform 2)Phosphorylation-25159151
80PhosphorylationFDGASLASDKNDCKT
CCCCHHCCCCCCCCC
23312004
91UbiquitinationDCKTESKNDPKTERK
CCCCCCCCCCCCCHH
29967540
95PhosphorylationESKNDPKTERKKSSS
CCCCCCCCCHHHCCC
20068231
100PhosphorylationPKTERKKSSSSSQYK
CCCCHHHCCCHHHHH
30576142
101PhosphorylationKTERKKSSSSSQYKA
CCCHHHCCCHHHHHH
20068231
102PhosphorylationTERKKSSSSSQYKAN
CCHHHCCCHHHHHHH
20068231
103PhosphorylationERKKSSSSSQYKANM
CHHHCCCHHHHHHHH
30576142
104PhosphorylationRKKSSSSSQYKANMH
HHHCCCHHHHHHHHH
20068231
106PhosphorylationKSSSSSQYKANMHFH
HCCCHHHHHHHHHHH
30576142
107UbiquitinationSSSSSQYKANMHFHK
CCCHHHHHHHHHHHH
29967540
115UbiquitinationANMHFHKLFLSVPTE
HHHHHHHHHHCCCCC
29967540
118PhosphorylationHFHKLFLSVPTEEPL
HHHHHHHCCCCCCCC
29978859
121PhosphorylationKLFLSVPTEEPLKQS
HHHHCCCCCCCCCHH
29978859
122UbiquitinationLFLSVPTEEPLKQSF
HHHCCCCCCCCCHHH
29967540
164PhosphorylationFGKDTKISIPAFSVT
HCCCCEEEEEEEEEE
25332170
169PhosphorylationKISIPAFSVTLIKKT
EEEEEEEEEEEECCC
25332170
171PhosphorylationSIPAFSVTLIKKTKT
EEEEEEEEEECCCCC
-
193UbiquitinationLIIATVTDRYIFVSL
EEEEEECCCHHHHHH
29967540
195UbiquitinationIATVTDRYIFVSLLS
EEEECCCHHHHHHHC
29967540
195PhosphorylationIATVTDRYIFVSLLS
EEEECCCHHHHHHHC
19664994
199PhosphorylationTDRYIFVSLLSRDST
CCCHHHHHHHCCHHH
24719451
202PhosphorylationYIFVSLLSRDSTYKL
HHHHHHHCCHHHHHH
24719451
205PhosphorylationVSLLSRDSTYKLLKS
HHHHCCHHHHHHHHH
20068231
206PhosphorylationSLLSRDSTYKLLKSV
HHHCCHHHHHHHHHH
20068231
207PhosphorylationLLSRDSTYKLLKSVC
HHCCHHHHHHHHHHH
20068231
211UbiquitinationDSTYKLLKSVCGHLE
HHHHHHHHHHHCCHH
29967540
212PhosphorylationSTYKLLKSVCGHLEN
HHHHHHHHHHCCHHC
23927012
219UbiquitinationSVCGHLENTSVGNSP
HHHCCHHCCCCCCCC
29967540
220PhosphorylationVCGHLENTSVGNSPN
HHCCHHCCCCCCCCC
30278072
221PhosphorylationCGHLENTSVGNSPNP
HCCHHCCCCCCCCCC
28355574
225PhosphorylationENTSVGNSPNPSSAE
HCCCCCCCCCCCHHC
28355574
226UbiquitinationNTSVGNSPNPSSAEN
CCCCCCCCCCCHHCC
29967540
229PhosphorylationVGNSPNPSSAENSFR
CCCCCCCCHHCCCCC
23663014
230UbiquitinationGNSPNPSSAENSFRA
CCCCCCCHHCCCCCC
29967540
230PhosphorylationGNSPNPSSAENSFRA
CCCCCCCHHCCCCCC
23927012
234PhosphorylationNPSSAENSFRADRPS
CCCHHCCCCCCCCCC
23663014
241PhosphorylationSFRADRPSSLPLDFN
CCCCCCCCCCCCCCC
30266825
242PhosphorylationFRADRPSSLPLDFND
CCCCCCCCCCCCCCC
30266825
252PhosphorylationLDFNDEFSDLDGVVQ
CCCCCCCCCCHHHHH
30266825
270PhosphorylationQDMEGYSSSGSQTPE
HHHCCCCCCCCCCCC
27251275
271PhosphorylationDMEGYSSSGSQTPES
HHCCCCCCCCCCCCC
27251275
273PhosphorylationEGYSSSGSQTPESEN
CCCCCCCCCCCCCCC
27251275
275PhosphorylationYSSSGSQTPESENSR
CCCCCCCCCCCCCCC
30242111
278PhosphorylationSGSQTPESENSRDFH
CCCCCCCCCCCCCEE
27251275
281UbiquitinationQTPESENSRDFHATE
CCCCCCCCCCEEECC
29967540
287PhosphorylationNSRDFHATESQTVLN
CCCCEEECCEEEEEE
28857561
289PhosphorylationRDFHATESQTVLNVS
CCEEECCEEEEEEEC
28857561
291PhosphorylationFHATESQTVLNVSKG
EEECCEEEEEEECCC
28857561
296PhosphorylationSQTVLNVSKGEAKPT
EEEEEEECCCCCCCC
20068231
297UbiquitinationQTVLNVSKGEAKPTR
EEEEEECCCCCCCCC
29967540
305UbiquitinationGEAKPTRADAHVNRV
CCCCCCCCCCCCCCC
29967540
312UbiquitinationADAHVNRVPEGKAKS
CCCCCCCCCCCCCCC
29967540
318UbiquitinationRVPEGKAKSLPVQGL
CCCCCCCCCCCCCCH
29967540
319PhosphorylationVPEGKAKSLPVQGLS
CCCCCCCCCCCCCHH
23898821
326PhosphorylationSLPVQGLSETVGILH
CCCCCCHHHHHHHHH
18452278
334UbiquitinationETVGILHKVKSQKCP
HHHHHHHHHHHCCCC
29967540
342UbiquitinationVKSQKCPMLHHILIF
HHHCCCCHHHHHHHH
29967540
349UbiquitinationMLHHILIFYAIVVCA
HHHHHHHHHHHHHHH
29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GRM2B_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GRM2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GRM2B_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GRM2B_HUMANGRAMD3physical
25416956
FRMD8_HUMANFRMD8physical
25416956
PNCB_HUMANNAPRTphysical
25416956
GRM1B_HUMANGRAMD1Bphysical
26186194
GRM1C_HUMANGRAMD1Cphysical
26186194
GRM1A_HUMANGRAMD1Aphysical
26186194
EFC14_HUMANEFCAB14physical
26186194
TXLNG_HUMANTXLNGphysical
26186194
EXD2_HUMANEXD2physical
26186194
TXLNA_HUMANTXLNAphysical
26186194
GOLM1_HUMANGOLM1physical
26186194
CASC4_HUMANCASC4physical
26186194
SEC20_HUMANBNIP1physical
26186194
YETS4_HUMANYEATS4physical
26186194
MARH5_HUMANMARCH5physical
26186194
HOME1_HUMANHOMER1physical
26186194
TXD15_HUMANTXNDC15physical
26186194
DDRGK_HUMANDDRGK1physical
26186194
EFC14_HUMANEFCAB14physical
28514442
GRM1C_HUMANGRAMD1Cphysical
28514442
GRM1B_HUMANGRAMD1Bphysical
28514442
CASC4_HUMANCASC4physical
28514442
EXD2_HUMANEXD2physical
28514442
GRM1A_HUMANGRAMD1Aphysical
28514442
GOLM1_HUMANGOLM1physical
28514442
TXD15_HUMANTXNDC15physical
28514442
TXLNG_HUMANTXLNGphysical
28514442
MARH5_HUMANMARCH5physical
28514442
DDRGK_HUMANDDRGK1physical
28514442
TXLNA_HUMANTXLNAphysical
28514442
HOME1_HUMANHOMER1physical
28514442
SEC20_HUMANBNIP1physical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GRM2B_HUMAN

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Related Literatures of Post-Translational Modification

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