SCAPE_HUMAN - dbPTM
SCAPE_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCAPE_HUMAN
UniProt AC Q9BY12
Protein Name S phase cyclin A-associated protein in the endoplasmic reticulum
Gene Name SCAPER
Organism Homo sapiens (Human).
Sequence Length 1400
Subcellular Localization Endoplasmic reticulum . Nucleus . Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus.
Protein Description CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm..
Protein Sequence MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKTRHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKTDAQSRPTSLAWEVKKMSPGRHVIPSPSTDRINVTSNARRSLNFGGSTGTVPAPRLAPTGVSWADKVKAHHTGSTASSEITPAQSCPPMTVQKASRKNERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQAVVPATNVNTVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQAWEEARQFFLKKEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMMASFQRSNSHDKVR
CCCCCCCCCCHHHHH		45.6226074081
10PhosphorylationASFQRSNSHDKVRRI
CCCCCCCCHHHHHHH		43.0626074081
59PhosphorylationSKRTIQGTHKTTKQS
CCCEECCCCCCCCCC		32.0829978859
62PhosphorylationTIQGTHKTTKQSTAV
EECCCCCCCCCCCEE		31.7129978859
63PhosphorylationIQGTHKTTKQSTAVD
ECCCCCCCCCCCEEE		47.7029978859
67UbiquitinationHKTTKQSTAVDCKIT
CCCCCCCCEEEEEEE		10.6129967540
84UbiquitinationTTGDKHFDKSPTKTR
CCCCCCCCCCCCCCC		58.3429967540
86PhosphorylationGDKHFDKSPTKTRHP
CCCCCCCCCCCCCCC		43.5923401153
88PhosphorylationKHFDKSPTKTRHPRK
CCCCCCCCCCCCCCH		47.1223927012
97UbiquitinationTRHPRKIDLRARYWA
CCCCCHHHHHHHHHH		5.4129967540
156UbiquitinationDWIQLQEKLEKTDAQ
HHHHHHHHHHCCCCC		8.8629967540
177PhosphorylationAWEVKKMSPGRHVIP
HHHHHCCCCCCCCCC		40.1030576142
185PhosphorylationPGRHVIPSPSTDRIN
CCCCCCCCCCCCCEE		35.5725849741
187PhosphorylationRHVIPSPSTDRINVT
CCCCCCCCCCCEECC		32.4523401153
188PhosphorylationHVIPSPSTDRINVTS
CCCCCCCCCCEECCC		54.5223401153
194PhosphorylationSTDRINVTSNARRSL
CCCCEECCCCCCHHH		24.9823532336
195PhosphorylationTDRINVTSNARRSLN
CCCEECCCCCCHHHC		28.2723532336
200PhosphorylationVTSNARRSLNFGGST
CCCCCCHHHCCCCCC		6.1325159151
206PhosphorylationRSLNFGGSTGTVPAP
HHHCCCCCCCCCCCC		39.9030576142
207PhosphorylationSLNFGGSTGTVPAPR
HHCCCCCCCCCCCCC		26.8126434776
209PhosphorylationNFGGSTGTVPAPRLA
CCCCCCCCCCCCCCC		3.9426434776
237PhosphorylationHTGSTASSEITPAQS
CCCCCCCCCCCCCHH		48.6828555341
260UbiquitinationASRKNERKDAEGWET
CCCCCCCCCCCCHHH		56.9529967540
276PhosphorylationQRGRPIRSRSTAVMP
HCCCCCCCCCCCCCC		28.3324719451
278PhosphorylationGRPIRSRSTAVMPKV
CCCCCCCCCCCCCCH		23.3528348404
279PhosphorylationRPIRSRSTAVMPKVS
CCCCCCCCCCCCCHH		9.2528348404
289PhosphorylationMPKVSLATEATRSKD
CCCHHHHHHHHCCCC		42.3030576142
294PhosphorylationLATEATRSKDDSDKE
HHHHHHCCCCCCCCC		63.3630576142
298PhosphorylationATRSKDDSDKENVCL
HHCCCCCCCCCCEEE		70.0926657352
310PhosphorylationVCLLPDESIQKGQFV
EEECCHHHCCCCCCC		4.6427251275
313UbiquitinationLPDESIQKGQFVGDG
CCHHHCCCCCCCCCC		15.1329967540
325UbiquitinationGDGTSNTIESHPKDS
CCCCCCCHHCCCCCC		40.7429967540
330UbiquitinationNTIESHPKDSLHSCD
CCHHCCCCCCCCCCC		61.9629967540
335UbiquitinationHPKDSLHSCDHPLAE
CCCCCCCCCCCCCCC		3.7629967540
337UbiquitinationKDSLHSCDHPLAEKT
CCCCCCCCCCCCCCC		24.4929967540
343UbiquitinationCDHPLAEKTQFTVST
CCCCCCCCCCEEEEE		22.0329967540
344PhosphorylationDHPLAEKTQFTVSTL
CCCCCCCCCEEEEEH		42.98-
351UbiquitinationTQFTVSTLDDVKNSG
CCEEEEEHHHHHCCC		59.7629967540
367PhosphorylationIRDNYVRTSEISAVH
CCCCEEECCCCEEEE		23.51-
368PhosphorylationRDNYVRTSEISAVHI
CCCEEECCCCEEEEE		40.11-
371PhosphorylationYVRTSEISAVHIDTE
EEECCCCEEEEECHH		11.54-
376UbiquitinationEISAVHIDTECVSVM
CCEEEEECHHHHHHH		30.5929967540
377PhosphorylationISAVHIDTECVSVML
CEEEEECHHHHHHHH		29.22-
391UbiquitinationLQAGTPPLQVNEEKF
HHCCCCCCCCCHHHC		41.5929967540
398UbiquitinationLQVNEEKFPAEKARI
CCCCHHHCHHHHHHH		51.0529967540
400UbiquitinationVNEEKFPAEKARIEN
CCHHHCHHHHHHHCC		47.7029967540
402UbiquitinationEEKFPAEKARIENEM
HHHCHHHHHHHCCCC		14.8029967540
448UbiquitinationASAIAEEEQLTREIE
HHHHHHHHHHHHHHH		51.9529967540
474UbiquitinationDNDSDFSASMGSGSV
CCCCCCCCCCCCCCE		23.6022505724
497PhosphorylationWNDVLADYEARESWR
HHHHHHHHHHHHHHH		41.62-
498UbiquitinationNDVLADYEARESWRQ
HHHHHHHHHHHHHHH		17.8229967540
499UbiquitinationDVLADYEARESWRQN
HHHHHHHHHHHHHHC		26.9229967540
503UbiquitinationDYEARESWRQNTSWG
HHHHHHHHHHCCCHH		29.2029967540
521UbiquitinationEEEPARPPGHGIHMH
CCCCCCCCCCCCCCC		34.0429967540
532PhosphorylationIHMHEKLSSPSRKRT
CCCCCCCCCHHHHHH		37.0128985074
533PhosphorylationHMHEKLSSPSRKRTI
CCCCCCCCHHHHHHH		34.4726074081
535PhosphorylationHEKLSSPSRKRTIAE
CCCCCCHHHHHHHHH		35.5426074081
537UbiquitinationKLSSPSRKRTIAESK
CCCCHHHHHHHHHHH		30.19-
538UbiquitinationLSSPSRKRTIAESKK
CCCHHHHHHHHHHHH		27.8129967540
539PhosphorylationSSPSRKRTIAESKKK
CCHHHHHHHHHHHHH		4.6826074081
544UbiquitinationKRTIAESKKKHEEKQ
HHHHHHHHHHHHHHH		69.51-
571UbiquitinationEKTLKLQKLLEREKD
HHHHHHHHHHHHHHH		3.7629967540
581UbiquitinationEREKDVRKWKEELLD
HHHHHHHHHHHHHHH		11.6129967540
583UbiquitinationEKDVRKWKEELLDQR
HHHHHHHHHHHHHHH		53.4129967540
597AcetylationRRRMMEEKLLHAEFK
HHHHHHHHHHHHHHH		4.857975705
597UbiquitinationRRRMMEEKLLHAEFK
HHHHHHHHHHHHHHH		4.8529967540
622UbiquitinationKAQEEEAKVNEIAFI
HHHHHHHHHHHHHHH		11.3629967540
637UbiquitinationNTLEAQNKRHDVLSK
HHHHHHHHHHHHHHH		38.5029967540
638UbiquitinationTLEAQNKRHDVLSKL
HHHHHHHHHHHHHHH		31.0129967540
643PhosphorylationNKRHDVLSKLKEYEQ
HHHHHHHHHHHHHHH		60.4622210691
644UbiquitinationKRHDVLSKLKEYEQR
HHHHHHHHHHHHHHH		4.5929967540
646UbiquitinationHDVLSKLKEYEQRLN
HHHHHHHHHHHHHHH		65.8129967540
647UbiquitinationDVLSKLKEYEQRLNE
HHHHHHHHHHHHHHH		18.7729967540
668UbiquitinationRRQEEKQARDEAVQE
HHHHHHHHHHHHHHH		39.5529967540
682UbiquitinationERKRALEAERQARVE
HHHHHHHHHHHHHHH		35.6329967540
694UbiquitinationRVEELLMKRKEQEAR
HHHHHHHHHHHHHHH		33.5029967540
744UbiquitinationEAMEELQKKIQLKHD
HHHHHHHHHHHHHCH		23.7929967540
745UbiquitinationAMEELQKKIQLKHDE
HHHHHHHHHHHHCHH		8.1629967540
749UbiquitinationLQKKIQLKHDESIRR
HHHHHHHHCHHHHHH		53.3029967540
767UbiquitinationQIEQRKEKAAELSSG
HHHHHHHHHHHHHCC		13.7829967540
779PhosphorylationSSGRHANTDYAPKLT
HCCCCCCCCCCCCCC		37.09-
781PhosphorylationGRHANTDYAPKLTPY
CCCCCCCCCCCCCHH		9.5027642862
784UbiquitinationANTDYAPKLTPYERK
CCCCCCCCCCHHHHH		5.9329967540
786PhosphorylationTDYAPKLTPYERKKQ
CCCCCCCCHHHHHHC		39.1528555341
788PhosphorylationYAPKLTPYERKKQCS
CCCCCCHHHHHHCCC		60.26-
807UbiquitinationLISSEVYLFSHVKGR
EECCCHHHHHHCCCC		2.3222505724
813UbiquitinationYLFSHVKGRKHQQAV
HHHHHCCCCHHHHHH		27.8022505724
825PhosphorylationQAVRENTSIQGRELS
HHHHHCCCCCCCCCC		4.7823532336
832PhosphorylationSIQGRELSDEEVEHL
CCCCCCCCHHHHHHH		69.5625159151
840UbiquitinationDEEVEHLSLKKYIID
HHHHHHHHHHHHHHH		7.5429967540
840PhosphorylationDEEVEHLSLKKYIID
HHHHHHHHHHHHHHH		7.5424719451
842UbiquitinationEVEHLSLKKYIIDIV
HHHHHHHHHHHHHEE		47.1522505724
842AcetylationEVEHLSLKKYIIDIV
HHHHHHHHHHHHHEE		47.1525953088
848UbiquitinationLKKYIIDIVVESTAP
HHHHHHHEEEECCCC		3.2922505724
884UbiquitinationARMNFRAKEYESLME
HHHHHCHHHHHHHHH		54.2529967540
886PhosphorylationMNFRAKEYESLMETK
HHHCHHHHHHHHHHC		38.1920860994
888PhosphorylationFRAKEYESLMETKNS
HCHHHHHHHHHHCCC		2.1020860994
893UbiquitinationYESLMETKNSGSDSP
HHHHHHHCCCCCCCH		60.0529967540
899PhosphorylationTKNSGSDSPYKAKLQ
HCCCCCCCHHHHHHH		39.37-
914UbiquitinationRLAKDLLKQVQVQDS
HHHHHHHHHCCCCCC		30.7429967540
921PhosphorylationKQVQVQDSGSWANNK
HHCCCCCCCCCCCCH		35.1823532336
923PhosphorylationVQVQDSGSWANNKVS
CCCCCCCCCCCCHHH		13.4123532336
928UbiquitinationSGSWANNKVSALDRT
CCCCCCCHHHHHHHH		4.3829967540
954UbiquitinationNVADQIAFQAAGGLT
CHHHHHHHHHHCHHH		22.6822505724
960UbiquitinationAFQAAGGLTALEHIL
HHHHHCHHHHHHHHH		32.2622505724
986PhosphorylationVLRIPPKSLCNAINV
CEECCCHHHHCHHHE		3.05-
994PhosphorylationLCNAINVYNLTCNNC
HHCHHHEEEECCCCC		25.29-
997PhosphorylationAINVYNLTCNNCSEN
HHHEEEECCCCCCCC		3.77-
1015PhosphorylationVLFSNKITFLMDLLI
HHHCCHHHHHHHHHH		6.40-
1050PhosphorylationKQVFEGLTTGLLKVS
CHHHCHHCHHHHHHH		30.7617924679
1051PhosphorylationQVFEGLTTGLLKVSA
HHHCHHCHHHHHHHH		24.6317924679
1078UbiquitinationGNCQPATPKIPTQEM
CCCCCCCCCCCCHHH		57.8922505724
1086UbiquitinationKIPTQEMKNKPSQGD
CCCCHHHCCCCCCCC		61.2229967540
1088UbiquitinationPTQEMKNKPSQGDPF
CCHHHCCCCCCCCCC		41.0822505724
1094UbiquitinationNKPSQGDPFNNRVQD
CCCCCCCCCCHHHHH		17.5922505724
1113UbiquitinationVVNMGLIDKLCACFL
HHHCCHHHHHHHHHH		38.1722505724
1119UbiquitinationIDKLCACFLSVQGPV
HHHHHHHHHHCCCCC		5.0222505724
1122UbiquitinationLCACFLSVQGPVDEN
HHHHHHHCCCCCCCC		47.2829967540
1208PhosphorylationTASPKENYTQNTIQV
CCCCCCCCCHHHHHH		27.25-
1368UbiquitinationQPYQPKGKCLGSQDY
CCCCCCCCCCCCHHH		7.6829967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCAPE_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCAPE_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCAPE_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SCAPE_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCAPE_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1050, AND MASSSPECTROMETRY.

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