DOPD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOPD_HUMAN
• UniProt AC: P30046
• Protein Name: D-dopachrome decarboxylase
• Gene Name: DDT
• Organism: Homo sapiens (Human).
• Sequence Length: 118
• Subcellular Localization: Cytoplasm.
• Protein Description: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)..
• Protein Sequence: MPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTKELALGQDRILIRFFPLESWQIGKIGTVMTFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MPFLELDTN ------CCCEECCCC	42.40	-
8	Phosphorylation	MPFLELDTNLPANRV CCCEECCCCCCCCCC	51.81	-
14	Methylation	DTNLPANRVPAGLEK CCCCCCCCCCCHHHH	37.59	-
21	Acetylation	RVPAGLEKRLCAAAA CCCCHHHHHHHHHHH	56.57	23749302
21	Ubiquitination	RVPAGLEKRLCAAAA CCCCHHHHHHHHHHH	56.57	21890473
21	Ubiquitination	RVPAGLEKRLCAAAA CCCCHHHHHHHHHHH	56.57	21890473
24	S-nitrosocysteine	AGLEKRLCAAAASIL CHHHHHHHHHHHHHH	2.55	-
24	S-nitrosylation	AGLEKRLCAAAASIL CHHHHHHHHHHHHHH	2.55	19483679
29	Phosphorylation	RLCAAAASILGKPAD HHHHHHHHHHCCCCC	17.39	24972180
33	Malonylation	AAASILGKPADRVNV HHHHHHCCCCCCCCE	33.32	26320211
33	Ubiquitination	AAASILGKPADRVNV HHHHHHCCCCCCCCE	33.32	-
33	Acetylation	AAASILGKPADRVNV HHHHHHCCCCCCCCE	33.32	26051181
76	Phosphorylation	GTAEDNRSHSAHFFE EEECCCCCCHHHHHH	28.22	25693802
78	Phosphorylation	AEDNRSHSAHFFEFL ECCCCCCHHHHHHHH	25.37	25693802
87	Ubiquitination	HFFEFLTKELALGQD HHHHHHHHHHHCCCC	53.53	-
95	Methylation	ELALGQDRILIRFFP HHHCCCCEEEEEECC	20.09	-
105	Phosphorylation	IRFFPLESWQIGKIG EEECCCCCCCCCCCE	31.78	21712546
110	Methylation	LESWQIGKIGTVMTF CCCCCCCCCEEEEEC	39.32	23644510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOPD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOPD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOPD_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DOPD_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.