SO4C1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SO4C1_HUMAN
• UniProt AC: Q6ZQN7
• Protein Name: Solute carrier organic anion transporter family member 4C1
• Gene Name: SLCO4C1 {ECO:0000312|EMBL:EAW49099.1, ECO:0000312|HGNC:HGNC:23612}
• Organism: Homo sapiens (Human).
• Sequence Length: 724
• Subcellular Localization: Basolateral cell membrane ; Multi-pass membrane protein . Detected at the basolateral membrane of the proximal tubule cell in the kidney.
• Protein Description: Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg..
• Protein Sequence: MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	ENLAFVPSSPDILRR CCEECCCCCHHHHHH	49.56	30266825
16	Phosphorylation	NLAFVPSSPDILRRL CEECCCCCHHHHHHH	22.11	30266825
24	Phosphorylation	PDILRRLSASPSQIE HHHHHHHCCCHHHEE	25.53	25849741
26	Phosphorylation	ILRRLSASPSQIEVS HHHHHCCCHHHEEHH	23.00	28450419
28	Phosphorylation	RRLSASPSQIEVSAL HHHCCCHHHEEHHHC	41.09	28450419
33	Phosphorylation	SPSQIEVSALSSDPQ CHHHEEHHHCCCCCC	15.65	30108239
77	Phosphorylation	VSEEKLRSLSLSEFE CCHHHHHHCCHHHCC	32.52	30266825
79	Phosphorylation	EEKLRSLSLSEFEEG HHHHHHCCHHHCCCC	30.97	30266825
81	Phosphorylation	KLRSLSLSEFEEGSY HHHHCCHHHCCCCCC	36.54	30266825
141	Phosphorylation	EKRYEMKSSLTGLIS HHHHHHHHHHHHHHC	29.30	-
203	Phosphorylation	SGEYKLGSLFEDTCV CCCEEHHHCEECEEE	40.08	-
208	Phosphorylation	LGSLFEDTCVTTRNS HHHCEECEEEECCCC	11.15	-
363	Ubiquitination	SNSNADVKFGKSIKD CCCCCCHHCCHHHHH	49.28	-
460	Phosphorylation	TMKFALFTSGVALTL HHHHHHHCCCHHHHH	25.97	19413330
461	Phosphorylation	MKFALFTSGVALTLS HHHHHHCCCHHHHHH	24.76	19413330
473	Phosphorylation	TLSFVFMYAKCENEP HHHHHHHHHHCCCCC	7.46	19413330
543	Phosphorylation	HRKPKVYYNCSCIER CCCCCEEEECCEEEC	16.81	-
551	"N6,N6-dimethyllysine"	NCSCIERKTEITSTA ECCEEECEEEECCHH	37.41	-
551	Methylation	NCSCIERKTEITSTA ECCEEECEEEECCHH	37.41	-
557	O-linked_Glycosylation	RKTEITSTAETFGFE CEEEECCHHHHHCCE	21.62	55825681

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SO4C1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SO4C1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SO4C1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SO4C1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.