NCKP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCKP5_HUMAN
• UniProt AC: O14513
• Protein Name: Nck-associated protein 5
• Gene Name: NCKAP5
• Organism: Homo sapiens (Human).
• Sequence Length: 1909
• Protein Sequence: MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRQSSQNWDKRLSIDSSLPSGFASPTNELPPTRIKESHILEGLRKLQKRKVLLEPPSVITKWGYKDCMNSNEGIYSPGIKSSSLKEYPPCKTADLGSPCKEPHKTFVYDLDSHVDADDDPSTLALLQAVPNQSCRPHGSKLTHSVSDSLFGWETNRKHFLEGTSSVYPKERPEKLTSCASSCPLEMKLCPSVQTPQVQRERGPQGQGHGRMALNLQLSDTDDNETFDELHIESSDEKSPSDVSLAADTDKSVENLDVLVGFGKSLCGSPEEEEKQVPIPSETRPKTFSFIKQQRVVKRTSSEECVTVIFDAEDGEPIEFSSHQTGVVTVTRNEISINSTPAGPKAEHTELLPQGIACLQPRAAARDYTFFKRSEEDTEKNIPKDNVDNVPRVSTESFSSRTVTQNPQQQKLVKPTHNISCQSNSRSSAPMGIYQKQNLTKIPPRGKSSPQKSKLMEPEATTLLPSSGLVTLEKSPALAPGKLSRFMKTESSGPLFELRSDPHIPKHSAQLPHSSRMPSRRDWVQCPKSQTPGSRSRPAIESSDSGEPPTRDEHCGSGPEAGVKSPSPPPPPGRSVSLLARPSYDYSPAPSSTKSETRVPSETARTPFKSPLLKGISAPVISSNPATTEVQRKKPSVAFKKPIFTHPMPSPEAVIQTRCPAHAPSSSFTVMALGPPKVSPKRGVPKTSPRQTLGTPQRDIGLQTPRISPSTHEPLEMTSSKSVSPGRKGQLNDSASTPPKPSFLGVNESPSSQVSSSSSSSSPAKSHNSPHGCQSAHEKGLKTRLPVGLKVLMKSPQLLRKSSTVPGKHEKDSLNEASKSSVAVNKSKPEDSKNPASMEITAGERNVTLPDSQAQGSLADGLPLETALQEPLESSIPGSDGRDGVDNRSMRRSLSSSKPHLKPALGMNGAKARSHSFSTHSGDKPSTPPIEGSGKVRTQIITNTAERGNSLTRQNSSTESSPNKAPSAPMLESLPSVGRPSGHPSSGKGSLGSSGSFSSQHGSPSKLPLRIPPKSEGLLIPPGKEDQQAFTQGECPSANVAVLGEPGSDRRSCPPTPTDCPEALQSPGRTQHPSTFETSSTSKLETSGRHPDASATATDAVSSEAPLSPTIEEKVMLCIQENVEKGQVQTKPTSVEAKQKPGPSFASWFGFRKSRLPALSSRKMDISKTKVEKKDAKVLGFGNRQLKSERKKEKKKPELQCETENELIKDTKSADNPDGGLQSKNNRRTPQDIYNQLKIEPRNRHSPVACSTKDTFMTELLNRVDKKAAPQTESGSSNASCRNVLKGSSQGSCLIGSSISTQGNHKKNMKIKADMEVPKDSLVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARGMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQDKAPRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RDFGKRLSLDSSLVE CCHHHCCCCCHHHHH	33.88	22199227
20	Phosphorylation	GKRLSLDSSLVEYMD HHCCCCCHHHHHHHH	30.75	22199227
21	Phosphorylation	KRLSLDSSLVEYMDS HCCCCCHHHHHHHHH	35.78	27251275
45	Phosphorylation	QLEEQHRSLWREKLA HHHHHHHHHHHHHHH	30.11	24719451
87	Phosphorylation	ERHLRLQSEKRLQEV HHHHHHHHHHHHHHH	50.07	-
113	O-linked_Glycosylation	RSLQQQFSRMEETVR HHHHHHHHHHHHHHH	26.78	30379171
125	Phosphorylation	TVRNLLQSQGSPEQK HHHHHHHHCCCHHHH	36.16	23186163
128	Phosphorylation	NLLQSQGSPEQKKEE HHHHHCCCHHHHHHH	20.02	20873877
133	Sumoylation	QGSPEQKKEETVNIM CCCHHHHHHHEEEEE	61.55	-
133	Sumoylation	QGSPEQKKEETVNIM CCCHHHHHHHEEEEE	61.55	-
136	Phosphorylation	PEQKKEETVNIMVYQ HHHHHHHEEEEEEEH	21.68	29759185
142	Phosphorylation	ETVNIMVYQEKLSEE HEEEEEEEHHHCCHH	8.12	29759185
147	Phosphorylation	MVYQEKLSEEERKHK EEEHHHCCHHHHHHH	54.77	21815630
170	Phosphorylation	VVDEDSRSESSSTDE CCCCCCCCCCCCCHH	45.87	-
227	Phosphorylation	QVVQALLTQKDLREE HHHHHHHCCHHHHHH	34.13	20068231
279	Phosphorylation	HSRLLDLSSGDLLSE HHHHHCCCCCCHHHH	31.76	28348404
280	Phosphorylation	SRLLDLSSGDLLSEV HHHHCCCCCCHHHHH	43.56	28348404
296	Phosphorylation	RNRSLTQSRTDAEVH HHHHHCCCCCHHHHH	31.73	30576142
298	Phosphorylation	RSLTQSRTDAEVHEH HHHCCCCCHHHHHHH	44.82	30576142
311	Phosphorylation	EHQLNTKSALKCPGL HHHHCCCHHHCCCCC	36.47	30576142
331	Phosphorylation	GHLCPRNSYSSSSEL CCCCCCCCCCCCCCE	27.89	-
332	Phosphorylation	HLCPRNSYSSSSELS CCCCCCCCCCCCCEE	19.00	30576142
334	Phosphorylation	CPRNSYSSSSELSLS CCCCCCCCCCCEEEC	29.65	-
336	Phosphorylation	RNSYSSSSELSLSST CCCCCCCCCEEECCC	44.50	30576142
339	Phosphorylation	YSSSSELSLSSTCSE CCCCCCEEECCCCCC	23.35	-
343	Phosphorylation	SELSLSSTCSEYSSG CCEEECCCCCCCCCC	19.37	-
348	Phosphorylation	SSTCSEYSSGSSYTW CCCCCCCCCCCCCCC	24.95	30576142
349	Phosphorylation	STCSEYSSGSSYTWH CCCCCCCCCCCCCCC	41.62	-
352	Phosphorylation	SEYSSGSSYTWHDGK CCCCCCCCCCCCCCC	30.06	-
353	Phosphorylation	EYSSGSSYTWHDGKN CCCCCCCCCCCCCCC	18.62	-
354	Phosphorylation	YSSGSSYTWHDGKNL CCCCCCCCCCCCCCC	20.47	-
432	Phosphorylation	GYKDCMNSNEGIYSP CHHHHCCCCCCCCCC	14.91	28348404
437	Phosphorylation	MNSNEGIYSPGIKSS CCCCCCCCCCCCCCC	21.48	25627689
438	Phosphorylation	NSNEGIYSPGIKSSS CCCCCCCCCCCCCCC	18.09	21815630
459	Phosphorylation	CKTADLGSPCKEPHK CCCCCCCCCCCCCCC	34.13	21815630
504	Phosphorylation	RPHGSKLTHSVSDSL CCCCCCCCEEHHHHH	18.81	29083192
506	Phosphorylation	HGSKLTHSVSDSLFG CCCCCCEEHHHHHCC	20.34	29083192
508	Phosphorylation	SKLTHSVSDSLFGWE CCCCEEHHHHHCCCC	25.21	29083192
510	Phosphorylation	LTHSVSDSLFGWETN CCEEHHHHHCCCCCC	20.35	29083192
525	Phosphorylation	RKHFLEGTSSVYPKE CHHHHCCCCCCCCCC	14.41	24732914
526	Phosphorylation	KHFLEGTSSVYPKER HHHHCCCCCCCCCCC	28.76	24732914
527	Phosphorylation	HFLEGTSSVYPKERP HHHCCCCCCCCCCCH	26.05	24732914
529	Phosphorylation	LEGTSSVYPKERPEK HCCCCCCCCCCCHHH	15.55	24732914
600	Phosphorylation	IESSDEKSPSDVSLA EECCCCCCHHHCCCC	27.82	25159151
602	Phosphorylation	SSDEKSPSDVSLAAD CCCCCCHHHCCCCCC	58.70	25159151
613	Phosphorylation	LAADTDKSVENLDVL CCCCCCCCHHCHHEE	37.16	27251275
630	Phosphorylation	FGKSLCGSPEEEEKQ CCHHHCCCCHHHHCC	28.30	21815630
642	Phosphorylation	EKQVPIPSETRPKTF HCCCCCCCCCCCCCH	52.93	24667141
644	Phosphorylation	QVPIPSETRPKTFSF CCCCCCCCCCCCHHH	57.52	24667141
650	Phosphorylation	ETRPKTFSFIKQQRV CCCCCCHHHHCCCEE	31.15	24719451
801	Phosphorylation	IYQKQNLTKIPPRGK EEECCCCCCCCCCCC	34.18	20068231
845	Phosphorylation	ALAPGKLSRFMKTES CCCCCCHHHHEECCC	27.27	28060719
850	Phosphorylation	KLSRFMKTESSGPLF CHHHHEECCCCCCCE	29.34	28060719
852	Phosphorylation	SRFMKTESSGPLFEL HHHEECCCCCCCEEE	45.91	21712546
853	Phosphorylation	RFMKTESSGPLFELR HHEECCCCCCCEEEC	37.89	21712546
897	Phosphorylation	SQTPGSRSRPAIESS CCCCCCCCCCCCCCC	44.29	20068231
926	Phosphorylation	GPEAGVKSPSPPPPP CCCCCCCCCCCCCCC	28.36	26657352
928	Phosphorylation	EAGVKSPSPPPPPGR CCCCCCCCCCCCCCC	58.07	22617229
938	Phosphorylation	PPPGRSVSLLARPSY CCCCCCEEEEECCCC	20.93	27251275
944	Phosphorylation	VSLLARPSYDYSPAP EEEEECCCCCCCCCC	25.69	-
967	Phosphorylation	VPSETARTPFKSPLL CCCCCCCCCCCCCCC	30.52	28555341
971	Phosphorylation	TARTPFKSPLLKGIS CCCCCCCCCCCCCCC	22.59	24719451
978	Phosphorylation	SPLLKGISAPVISSN CCCCCCCCCCEECCC	34.88	28348404
1056	Phosphorylation	SPRQTLGTPQRDIGL CCCCCCCCCCHHCCC	21.25	26853621
1069	Phosphorylation	GLQTPRISPSTHEPL CCCCCCCCCCCCCCC	17.68	25159151
1071	Phosphorylation	QTPRISPSTHEPLEM CCCCCCCCCCCCCCC	35.29	28348404
1072	Phosphorylation	TPRISPSTHEPLEMT CCCCCCCCCCCCCCC	33.37	28348404
1083	Phosphorylation	LEMTSSKSVSPGRKG CCCCCCCCCCCCCCC	29.76	-
1085	Phosphorylation	MTSSKSVSPGRKGQL CCCCCCCCCCCCCCC	28.82	-
1097	Phosphorylation	GQLNDSASTPPKPSF CCCCCCCCCCCCCCC	45.45	-
1103	Phosphorylation	ASTPPKPSFLGVNES CCCCCCCCCCCCCCC	38.95	-
1119	Phosphorylation	SSQVSSSSSSSSPAK CCCCCCCCCCCCCCH	35.87	25627689
1120	Phosphorylation	SQVSSSSSSSSPAKS CCCCCCCCCCCCCHH	35.87	25627689
1144	Phosphorylation	AHEKGLKTRLPVGLK HHHCCCCCCCCCHHH	42.34	28258704
1156	Phosphorylation	GLKVLMKSPQLLRKS HHHHHHCCHHHHHHC	12.15	21815630
1180	Acetylation	DSLNEASKSSVAVNK HCCCHHHHHHCCCCC	54.52	19820805
1181	Phosphorylation	SLNEASKSSVAVNKS CCCHHHHHHCCCCCC	27.78	20068231
1182	Phosphorylation	LNEASKSSVAVNKSK CCHHHHHHCCCCCCC	20.17	20068231
1187	Acetylation	KSSVAVNKSKPEDSK HHHCCCCCCCCCCCC	53.94	19820813
1188	Phosphorylation	SSVAVNKSKPEDSKN HHCCCCCCCCCCCCC	48.52	20068231
1189	Acetylation	SVAVNKSKPEDSKNP HCCCCCCCCCCCCCC	54.78	19820821
1193	Phosphorylation	NKSKPEDSKNPASME CCCCCCCCCCCCCCE	32.44	20068231
1198	Phosphorylation	EDSKNPASMEITAGE CCCCCCCCCEEEECC	20.43	20068231
1202	Phosphorylation	NPASMEITAGERNVT CCCCCEEEECCCCEE	18.46	20068231
1254	Phosphorylation	DNRSMRRSLSSSKPH CCHHHHHHHHCCCCC	23.41	24719451
1256	Phosphorylation	RSMRRSLSSSKPHLK HHHHHHHHCCCCCCC	33.54	28348404
1257	Phosphorylation	SMRRSLSSSKPHLKP HHHHHHHCCCCCCCC	47.91	28348404
1258	Phosphorylation	MRRSLSSSKPHLKPA HHHHHHCCCCCCCCC	46.99	28348404
1275	Phosphorylation	MNGAKARSHSFSTHS CCCHHHCCCCCCCCC	28.48	29449344
1277	Phosphorylation	GAKARSHSFSTHSGD CHHHCCCCCCCCCCC	23.34	29449344
1279	Phosphorylation	KARSHSFSTHSGDKP HHCCCCCCCCCCCCC	28.38	29449344
1280	Phosphorylation	ARSHSFSTHSGDKPS HCCCCCCCCCCCCCC	20.32	29449344
1282	Phosphorylation	SHSFSTHSGDKPSTP CCCCCCCCCCCCCCC	49.10	29449344
1287	Phosphorylation	THSGDKPSTPPIEGS CCCCCCCCCCCCCCC	60.32	26657352
1288	Phosphorylation	HSGDKPSTPPIEGSG CCCCCCCCCCCCCCC	41.43	29449344
1294	Phosphorylation	STPPIEGSGKVRTQI CCCCCCCCCCEEEEE	23.73	23403867
1354	Phosphorylation	SGKGSLGSSGSFSSQ CCCCCCCCCCCCCCC	36.50	28348404
1355	Phosphorylation	GKGSLGSSGSFSSQH CCCCCCCCCCCCCCC	36.34	28348404
1357	Phosphorylation	GSLGSSGSFSSQHGS CCCCCCCCCCCCCCC	24.73	28348404
1376	O-linked_Glycosylation	PLRIPPKSEGLLIPP CCCCCCCCCCEECCC	42.54	30379171
1417	Phosphorylation	DRRSCPPTPTDCPEA CCCCCCCCCCCCCHH	24.78	22210691
1419	Phosphorylation	RSCPPTPTDCPEALQ CCCCCCCCCCCHHHC	53.35	22210691
1431	Phosphorylation	ALQSPGRTQHPSTFE HHCCCCCCCCCCCCC	36.82	22210691
1455	Phosphorylation	SGRHPDASATATDAV CCCCCCCCCCHHHHC	33.27	23312004
1457	Phosphorylation	RHPDASATATDAVSS CCCCCCCCHHHHCCC	27.82	23312004
1459	Phosphorylation	PDASATATDAVSSEA CCCCCCHHHHCCCCC	21.82	23312004
1463	Phosphorylation	ATATDAVSSEAPLSP CCHHHHCCCCCCCCC	24.96	30108239
1464	Phosphorylation	TATDAVSSEAPLSPT CHHHHCCCCCCCCCC	31.04	30108239
1469	Phosphorylation	VSSEAPLSPTIEEKV CCCCCCCCCCHHHHH	20.95	30108239
1471	Phosphorylation	SEAPLSPTIEEKVML CCCCCCCCHHHHHHH	37.33	26471730
1494	Phosphorylation	GQVQTKPTSVEAKQK CCCCCCCCCCCCCCC	47.13	26270265
1495	Phosphorylation	QVQTKPTSVEAKQKP CCCCCCCCCCCCCCC	26.87	20068231
1521	Phosphorylation	KSRLPALSSRKMDIS HHHCHHHHHCCCCCC	30.15	24719451
1522	Phosphorylation	SRLPALSSRKMDISK HHCHHHHHCCCCCCC	36.45	-
1595	Phosphorylation	RRTPQDIYNQLKIEP CCCHHHHHHHHCCCC	12.73	27642862
1619	Phosphorylation	STKDTFMTELLNRVD CCHHHHHHHHHHHHC	21.20	28509920
1649	Phosphorylation	CRNVLKGSSQGSCLI HHHHHCCCCCCCEEE	20.21	22210691
1650	Phosphorylation	RNVLKGSSQGSCLIG HHHHCCCCCCCEEEC	47.42	22210691
1653	Phosphorylation	LKGSSQGSCLIGSSI HCCCCCCCEEECCEE	9.71	22210691
1658	Phosphorylation	QGSCLIGSSISTQGN CCCEEECCEECCCCC	19.94	29083192
1659	Phosphorylation	GSCLIGSSISTQGNH CCEEECCEECCCCCC	18.49	29083192
1661	Phosphorylation	CLIGSSISTQGNHKK EEECCEECCCCCCCC	19.34	29083192
1662	Phosphorylation	LIGSSISTQGNHKKN EECCEECCCCCCCCC	38.53	29083192
1738	Phosphorylation	GNRSTGRYLCQPDSP CCCCCCEEEECCCCH	17.11	19690332
1744	Phosphorylation	RYLCQPDSPEDAEPL EEEECCCCHHHCCCC	36.55	19690332
1762	Phosphorylation	QSALSAVSSMRAQTL HHHHHHHHHHHHHHH	20.38	19690332
1763	Phosphorylation	SALSAVSSMRAQTLE HHHHHHHHHHHHHHH	12.99	19690332
1790	Phosphorylation	ADSAIVHSTSDPIMT CCEEEEEECCCCCCC	20.79	27251275
1791	Phosphorylation	DSAIVHSTSDPIMTA CEEEEEECCCCCCCC	23.44	28348404
1792	Phosphorylation	SAIVHSTSDPIMTAR EEEEEECCCCCCCCC	44.39	28348404
1870	Phosphorylation	APRMCTYSASGGSNS CCCEEEEECCCCCCC	9.60	30576142
1877	Phosphorylation	SASGGSNSDSDLDYG ECCCCCCCCCCCCCC	39.94	30576142
1879	Phosphorylation	SGGSNSDSDLDYGDN CCCCCCCCCCCCCCC	39.63	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCKP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCKP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCKP5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NCKP5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.