| UniProt ID | MEIOB_HUMAN | |
|---|---|---|
| UniProt AC | Q8N635 | |
| Protein Name | Meiosis-specific with OB domain-containing protein | |
| Gene Name | MEIOB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 442 | |
| Subcellular Localization | Cytoplasm. Nucleus. Chromosome. Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22 (By similarity).. | |
| Protein Description | Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).. | |
| Protein Sequence | MANSFAARIFTTLSDLQTNMANLKVIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPAHFVNAASWGNEDYIKSLSDSFRVGDCVIIENPLIQRKEIEREEKFSPATPSNCKLLLSENHSTVKVCSSYEVDTKLLSLIHLPVKESHDYYSLGDIVANGHSLNGRIINVLAAVKSVGEPKYFTTSDRRKGQRCEVRLYDETESSFAMTCWDNESILLAQSWMPRETVIFASDVRINFDKFRNCMTATVISKTIITTNPDIPEANILLNFIRENKETNVLDDEIDSYFKESINLSTIVDVYTVEQLKGKALKNEGKADPSYGILYAYISTLNIDDETTKVVRNRCSSCGYIVNEASNMCTTCNKNSLDFKSVFLSFHVLIDLTDHTGTLHSCSLTGSVAEETLGCTFVLSHRARSGLKISVLSCKLADPTEASRNLSGQKHV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 54 | Phosphorylation | ERYTFSFTIRDSPAH CEEEEEEEECCCCCE | 24719451 | ||
| 76 | Phosphorylation | GNEDYIKSLSDSFRV CCHHHHHHHHHCCEE | 28857561 | ||
| 176 | Phosphorylation | NVLAAVKSVGEPKYF HHHHHHHCCCCCCCC | 27307780 | ||
| 246 | Phosphorylation | DKFRNCMTATVISKT HHHCCCCCEEEEEEE | 30206219 | ||
| 248 | Phosphorylation | FRNCMTATVISKTII HCCCCCEEEEEEEEE | 30206219 | ||
| 251 | Phosphorylation | CMTATVISKTIITTN CCCEEEEEEEEEECC | 30206219 | ||
| 277 | Phosphorylation | FIRENKETNVLDDEI HHHHCCCCCCCCHHH | 25954137 | ||
| 286 | Phosphorylation | VLDDEIDSYFKESIN CCCHHHHHHHHHHCC | 25954137 | ||
| 287 | Phosphorylation | LDDEIDSYFKESINL CCHHHHHHHHHHCCH | 25954137 | ||
| 295 | Phosphorylation | FKESINLSTIVDVYT HHHHCCHHHEEEEEE | 25954137 | ||
| 296 | Phosphorylation | KESINLSTIVDVYTV HHHCCHHHEEEEEEH | 25954137 | ||
| 366 | Phosphorylation | CTTCNKNSLDFKSVF CCCCCCCCCCHHHHH | 24719451 | ||
| 430 | Phosphorylation | SCKLADPTEASRNLS EEEECCCCHHHHCCC | 24670416 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MEIOB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MEIOB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MEIOB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| G3PT_HUMAN | GAPDHS | physical | 26186194 | |
| G3PT_HUMAN | GAPDHS | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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