DDHD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDHD1_HUMAN
• UniProt AC: Q8NEL9
• Protein Name: Phospholipase DDHD1
• Gene Name: DDHD1
• Organism: Homo sapiens (Human).
• Sequence Length: 900
• Subcellular Localization: Cytoplasm .
• Protein Description: Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity..
• Protein Sequence: MNYPGRGSPRSPEHNGRGGGGGAWELGSDARPAFGGGVCCFEHLPGGDPDDGDVPLALLRGEPGLHLAPGTDDHNHHLALDPCLSDENYDFSSAESGSSLRYYSEGESGGGGSSLSLHPPQQPPLVPTNSGGGGATGGSPGERKRTRLGGPAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQTTGARPQGGDRDGDHVCSPTGPASSSGEDDDEDRACGFCQSTTGHEPEMVELVNIEPVCVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLNCFRGQQMQENFDIEVSKSIDGKDAVHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLKEIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPSFLNPAKEPTSVSENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSTTQSSETSKDSMEDEKKPVASPSATTVGTQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVMQNKDNALVELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDDDAKPNLDPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MNYPGRGSPR -----CCCCCCCCCC	13.03	26074081
6	Methylation	--MNYPGRGSPRSPE --CCCCCCCCCCCCC	37.60	-
8	Phosphorylation	MNYPGRGSPRSPEHN CCCCCCCCCCCCCCC	18.77	26055452
11	Phosphorylation	PGRGSPRSPEHNGRG CCCCCCCCCCCCCCC	37.72	26055452
71	Phosphorylation	GLHLAPGTDDHNHHL CCCCCCCCCCCCCEE	36.88	27690223
85	Phosphorylation	LALDPCLSDENYDFS ECCCCCCCCCCCCCC	49.98	28796482
89	Phosphorylation	PCLSDENYDFSSAES CCCCCCCCCCCCCCC	19.13	28796482
92	Phosphorylation	SDENYDFSSAESGSS CCCCCCCCCCCCCCC	26.24	27690223
93	Phosphorylation	DENYDFSSAESGSSL CCCCCCCCCCCCCCE	35.73	27690223
128	Phosphorylation	QQPPLVPTNSGGGGA CCCCCCCCCCCCCCC	34.24	28122231
130	Phosphorylation	PPLVPTNSGGGGATG CCCCCCCCCCCCCCC	41.09	28122231
136	Phosphorylation	NSGGGGATGGSPGER CCCCCCCCCCCCCCC	45.40	28122231
139	Phosphorylation	GGGATGGSPGERKRT CCCCCCCCCCCCCCC	30.95	28464451
146	Phosphorylation	SPGERKRTRLGGPAA CCCCCCCCCCCCCCH	33.03	24719451
177	Ubiquitination	WFYKEDKKTWKPFIG EEEECCCCCCCCCCC	72.45	-
178	Phosphorylation	FYKEDKKTWKPFIGY EEECCCCCCCCCCCH	44.45	24719451
185	Phosphorylation	TWKPFIGYDSLRIEL CCCCCCCHHHHHHHH	9.50	24719451
187	Phosphorylation	KPFIGYDSLRIELAF CCCCCHHHHHHHHHH	15.86	28102081
200	Phosphorylation	AFRTLLQTTGARPQG HHHHHHHHHCCCCCC	27.45	24719451
219	Phosphorylation	GDHVCSPTGPASSSG CCCCCCCCCCCCCCC	39.23	27732954
223	Phosphorylation	CSPTGPASSSGEDDD CCCCCCCCCCCCCCC	28.33	23663014
224	Phosphorylation	SPTGPASSSGEDDDE CCCCCCCCCCCCCCC	44.46	23663014
225	Phosphorylation	PTGPASSSGEDDDED CCCCCCCCCCCCCCC	43.64	23663014
240	Phosphorylation	RACGFCQSTTGHEPE CCCCCCCCCCCCCCC	29.17	27080861
241	Phosphorylation	ACGFCQSTTGHEPEM CCCCCCCCCCCCCCE	15.77	27080861
242	Phosphorylation	CGFCQSTTGHEPEMV CCCCCCCCCCCCCEE	41.61	27080861
264	Phosphorylation	VCVRGGLYEVDVTQG EEEECCEEEEECCCC	19.72	-
332	Phosphorylation	FDIEVSKSIDGKDAV CCEEEECCCCCCCCC	20.57	22673903
341	Phosphorylation	DGKDAVHSFKLSRNH CCCCCCEEEEECCCC	19.92	23401153
362 (in isoform 3)	Phosphorylation	-	34.08	28122231
371	Phosphorylation	TTSKIARTVTQKLGF CHHHHHHHHHHHHCC	20.91	18669648
372 (in isoform 3)	Phosphorylation	-	4.44	28122231
374 (in isoform 3)	Phosphorylation	-	34.34	28122231
376 (in isoform 3)	Phosphorylation	-	6.35	28122231
377 (in isoform 3)	Phosphorylation	-	31.64	28122231
379	Phosphorylation	VTQKLGFSKASSSGT HHHHHCCCCCCCCCC	26.05	-
380	Ubiquitination	TQKLGFSKASSSGTR HHHHCCCCCCCCCCE	50.45	-
380 (in isoform 3)	Phosphorylation	-	50.45	28348404
382 (in isoform 3)	Phosphorylation	-	28.86	28348404
386	Phosphorylation	SKASSSGTRLHRGYV CCCCCCCCEEEECEE	31.82	-
386 (in isoform 3)	Phosphorylation	-	31.82	28348404
387 (in isoform 3)	Phosphorylation	-	31.83	28348404
388 (in isoform 3)	Phosphorylation	-	3.03	28348404
393 (in isoform 3)	Phosphorylation	-	6.28	28122231
426	Ubiquitination	MDQGRIIKNTAMMRE CCCCHHHHHHHHHHH	45.96	29967540
428	O-linked_Glycosylation	QGRIIKNTAMMREAA CCHHHHHHHHHHHHH	15.78	30379171
433	Ubiquitination	KNTAMMREAARKIEE HHHHHHHHHHHHHHH	28.87	29967540
435 (in isoform 3)	Ubiquitination	-	14.46	21906983
460	Ubiquitination	LPVEWRSKLTLDGDT ECCEECCEEECCCCC	36.60	29967540
460 (in isoform 3)	Ubiquitination	-	36.60	21906983
467	Ubiquitination	KLTLDGDTVDSITPD EEECCCCCCCCCCHH	31.57	29967540
475	Ubiquitination	VDSITPDKVRGLRDM CCCCCHHHHHHHHHH	34.73	29967540
482	Ubiquitination	KVRGLRDMLNSSAMD HHHHHHHHHCHHCCH	2.85	29967540
498	Phosphorylation	MYYTSPLYRDELVKG HHHCCHHHHHHHHHH	21.28	22210691
519	Phosphorylation	RLYSLFCSRNPDFEE HHHHHHHCCCCCHHH	27.97	30631047
519	Ubiquitination	RLYSLFCSRNPDFEE HHHHHHHCCCCCHHH	27.97	22817900
544	Ubiquitination	SLGCVITYDIMTGWN CCCCEEEEECCCCCC	7.73	22817900
548	Ubiquitination	VITYDIMTGWNPVRL EEEEECCCCCCHHHH	39.10	22817900
556	Phosphorylation	GWNPVRLYEQLLQKE CCCHHHHHHHHHHHC	7.35	27642862
562	Ubiquitination	LYEQLLQKEEELPDE HHHHHHHHCCCCCCH	68.04	22817900
562 (in isoform 1)	Ubiquitination	-	68.04	21906983
562 (in isoform 2)	Ubiquitination	-	68.04	21906983
569	Ubiquitination	KEEELPDERWMSYEE HCCCCCCHHHCCHHH	46.43	22817900
584	Phosphorylation	RHLLDELYITKRRLK HHHHHHHHHHHHHHH	12.42	25884760
587	Ubiquitination	LDELYITKRRLKEIE HHHHHHHHHHHHHHH	26.43	22817900
587 (in isoform 1)	Ubiquitination	-	26.43	21906983
587 (in isoform 2)	Ubiquitination	-	26.43	21906983
591	Acetylation	YITKRRLKEIEERLH HHHHHHHHHHHHHHH	55.63	30588027
591	Ubiquitination	YITKRRLKEIEERLH HHHHHHHHHHHHHHH	55.63	22817900
594	Ubiquitination	KRRLKEIEERLHGLK HHHHHHHHHHHHCCC	37.85	32015554
596	Ubiquitination	RLKEIEERLHGLKAS HHHHHHHHHHCCCCC	21.13	22817900
598	Ubiquitination	KEIEERLHGLKASSM HHHHHHHHCCCCCCC	45.84	22817900
601	Methylation	EERLHGLKASSMTQT HHHHHCCCCCCCCCC	51.30	-
601	Ubiquitination	EERLHGLKASSMTQT HHHHHCCCCCCCCCC	51.30	29967540
603	Phosphorylation	RLHGLKASSMTQTPA HHHCCCCCCCCCCCC	21.03	-
603	Ubiquitination	RLHGLKASSMTQTPA HHHCCCCCCCCCCCC	21.03	22817900
604	Phosphorylation	LHGLKASSMTQTPAL HHCCCCCCCCCCCCC	30.61	-
608	Ubiquitination	KASSMTQTPALKFKV CCCCCCCCCCCCCEE	11.02	29967540
612	Methylation	MTQTPALKFKVENFF CCCCCCCCCEEEEEE	45.29	-
614	Methylation	QTPALKFKVENFFCM CCCCCCCEEEEEEEC	47.23	-
621	Ubiquitination	KVENFFCMGSPLAVF EEEEEEECCCHHHHH	5.14	22817900
625	Ubiquitination	FFCMGSPLAVFLALR EEECCCHHHHHHHHC	7.32	22817900
628	Ubiquitination	MGSPLAVFLALRGIR CCCHHHHHHHHCCCC	2.48	22817900
632	Ubiquitination	LAVFLALRGIRPGNT HHHHHHHCCCCCCCC	32.65	22817900
639	Phosphorylation	RGIRPGNTGSQDHIL CCCCCCCCCCCCCCC	44.09	25278378
641	Phosphorylation	IRPGNTGSQDHILPR CCCCCCCCCCCCCHH	30.32	25278378
710	Phosphorylation	LNPAKEPTSVSENEG CCCCCCCCCCCCCCC	42.74	29255136
711	Phosphorylation	NPAKEPTSVSENEGI CCCCCCCCCCCCCCC	34.07	29255136
713	Phosphorylation	AKEPTSVSENEGIST CCCCCCCCCCCCCCC	34.18	28450419
719	Phosphorylation	VSENEGISTIPSPVT CCCCCCCCCCCCCCC	31.01	30266825
720	Phosphorylation	SENEGISTIPSPVTS CCCCCCCCCCCCCCC	34.68	30266825
723	Phosphorylation	EGISTIPSPVTSPVL CCCCCCCCCCCCCCC	28.31	30266825
726	Phosphorylation	STIPSPVTSPVLSRR CCCCCCCCCCCCCCC	30.60	30266825
727	Phosphorylation	TIPSPVTSPVLSRRH CCCCCCCCCCCCCCC	17.16	30266825
730	Phosphorylation	SPVTSPVLSRRHYGE CCCCCCCCCCCCCCC	3.61	32142685
731	Phosphorylation	PVTSPVLSRRHYGES CCCCCCCCCCCCCCC	27.74	30266825
734	Phosphorylation	SPVLSRRHYGESITN CCCCCCCCCCCCCCC	33.56	32142685
735	Phosphorylation	PVLSRRHYGESITNI CCCCCCCCCCCCCCC	22.30	26074081
738	Phosphorylation	SRRHYGESITNIGKA CCCCCCCCCCCCHHH	30.28	28555341
746	Phosphorylation	ITNIGKASILGAASI CCCCHHHHHHCHHHH	23.10	28634120
752	Phosphorylation	ASILGAASIGKGLGG HHHHCHHHHCCCHHH	31.19	25159151
755	Ubiquitination	LGAASIGKGLGGMLF HCHHHHCCCHHHHHH	49.66	-
763	Phosphorylation	GLGGMLFSRFGRSST CHHHHHHHHCCCCCC	23.80	-
768	Phosphorylation	LFSRFGRSSTTQSSE HHHHCCCCCCCCCCC	32.20	28985074
770	Phosphorylation	SRFGRSSTTQSSETS HHCCCCCCCCCCCCC	30.05	-
780 (in isoform 2)	Phosphorylation	-	28.01	28122231
787 (in isoform 4)	Phosphorylation	-	37.66	28122231
790	Phosphorylation	DEKKPVASPSATTVG CCCCCCCCCCCEECC	21.44	25849741
790 (in isoform 2)	Phosphorylation	-	21.44	28122231
792	Phosphorylation	KKPVASPSATTVGTQ CCCCCCCCCEECCCC	35.43	25849741
792 (in isoform 2)	Phosphorylation	-	35.43	28122231
794	Phosphorylation	PVASPSATTVGTQTL CCCCCCCEECCCCCC	26.76	26074081
794 (in isoform 2)	Phosphorylation	-	26.76	28122231
795	Phosphorylation	VASPSATTVGTQTLP CCCCCCEECCCCCCC	19.36	26074081
795 (in isoform 2)	Phosphorylation	-	19.36	28122231
797 (in isoform 4)	Phosphorylation	-	15.26	28122231
798	Phosphorylation	PSATTVGTQTLPHSS CCCEECCCCCCCCCC	17.66	26074081
798 (in isoform 2)	Phosphorylation	-	17.66	28348404
799 (in isoform 4)	Phosphorylation	-	34.80	28122231
800	Phosphorylation	ATTVGTQTLPHSSSG CEECCCCCCCCCCCC	41.94	26074081
800 (in isoform 2)	Phosphorylation	-	41.94	28348404
801 (in isoform 4)	Phosphorylation	-	2.30	28122231
802 (in isoform 4)	Phosphorylation	-	28.80	28122231
804	Phosphorylation	GTQTLPHSSSGFLDS CCCCCCCCCCCCCCH	25.02	30576142
804 (in isoform 2)	Phosphorylation	-	25.02	28348404
805	Phosphorylation	TQTLPHSSSGFLDSA CCCCCCCCCCCCCHH	31.29	26074081
805 (in isoform 2)	Phosphorylation	-	31.29	28348404
805 (in isoform 4)	Phosphorylation	-	31.29	28348404
806	Phosphorylation	QTLPHSSSGFLDSAY CCCCCCCCCCCCHHH	36.26	30576142
806 (in isoform 2)	Phosphorylation	-	36.26	28348404
807 (in isoform 4)	Phosphorylation	-	29.14	28348404
811	Phosphorylation	SSSGFLDSAYFRLQE CCCCCCCHHHHHHHH	27.32	29449344
811 (in isoform 2)	Phosphorylation	-	27.32	28122231
811 (in isoform 4)	Phosphorylation	-	27.32	28348404
812	Phosphorylation	SSGFLDSAYFRLQES CCCCCCHHHHHHHHH	13.72	27251275
812 (in isoform 4)	Phosphorylation	-	13.72	28348404
813 (in isoform 4)	Phosphorylation	-	7.99	28348404
818 (in isoform 4)	Phosphorylation	-	54.85	28122231
819	Phosphorylation	AYFRLQESFFNLPQL HHHHHHHHHHCCCHH	23.37	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDHD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDHD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDHD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDAC1_HUMAN	CDADC1	physical	27173435
SCML1_HUMAN	SCML1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 609340: Spastic paraplegia 28, autosomal recessive (SPG28)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.