GLCNE_HUMAN - dbPTM
GLCNE_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLCNE_HUMAN
UniProt AC Q9Y223
Protein Name Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Gene Name GNE
Organism Homo sapiens (Human).
Sequence Length 722
Subcellular Localization Cytoplasm.
Protein Description Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells..
Protein Sequence MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVKDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Ubiquitination-----MEKNGNNRKL
-----CCCCCCCCCE		69.7133845483
11 (in isoform 2)Phosphorylation-23.8730206219
19PhosphorylationVCVATCNRADYSKLA
EEEEECCCCCHHHHC		30.8624719451
19 (in isoform 3)Phosphorylation-30.8624719451
22PhosphorylationATCNRADYSKLAPIM
EECCCCCHHHHCCHH		13.51-
22UbiquitinationATCNRADYSKLAPIM
EECCCCCHHHHCCHH		13.5129967540
24UbiquitinationCNRADYSKLAPIMFG
CCCCCHHHHCCHHHC		42.30-
24 (in isoform 3)Phosphorylation-42.30-
34UbiquitinationPIMFGIKTEPEFFEL
CHHHCCCCCCCCEEC		55.6533845483
44UbiquitinationEFFELDVVVLGSHLI
CCEECEEEEECHHHH		2.6924816145
55 (in isoform 2)Ubiquitination-27.31-
60SulfoxidationDYGNTYRMIEQDDFD
CCCCEEEEEECCCCC		2.5221406390
84SulfoxidationRGEDEAAMVESVGLA
CCCCHHHHHHHHHHH		4.4130846556
98UbiquitinationALVKLPDVLNRLKPD
HHHCCHHHHHHCCCC		4.8824816145
103UbiquitinationPDVLNRLKPDIMIVH
HHHHHHCCCCEEEEE		37.0924816145
134UbiquitinationNIRILHIEGGEVSGT
CCEEEEEECCEEEEE		50.8523000965
136UbiquitinationRILHIEGGEVSGTID
EEEEEECCEEEEECC		21.2423000965
141PhosphorylationEGGEVSGTIDDSIRH
ECCEEEEECCHHHHH		17.4622210691
151UbiquitinationDSIRHAITKLAHYHV
HHHHHHHHHHHCCCE		22.3133845483
183UbiquitinationDRILLAGCPSYDKLL
CCEEECCCCCHHHHH		1.36-
188AcetylationAGCPSYDKLLSAKNK
CCCCCHHHHHHCCCC		42.99-
188UbiquitinationAGCPSYDKLLSAKNK
CCCCCHHHHHHCCCC		42.9923000965
190UbiquitinationCPSYDKLLSAKNKDY
CCCHHHHHHCCCCCH		6.03-
190UbiquitinationCPSYDKLLSAKNKDY
CCCHHHHHHCCCCCH		6.0323000965
193AcetylationYDKLLSAKNKDYMSI
HHHHHHCCCCCHHHH		62.2423749302
193UbiquitinationYDKLLSAKNKDYMSI
HHHHHHCCCCCHHHH		62.2423000965
195UbiquitinationKLLSAKNKDYMSIIR
HHHHCCCCCHHHHHH		49.9123000965
197PhosphorylationLSAKNKDYMSIIRMW
HHCCCCCHHHHHHHH		8.3820068231
199PhosphorylationAKNKDYMSIIRMWLG
CCCCCHHHHHHHHHC		14.5020068231
205UbiquitinationMSIIRMWLGDDVKSK
HHHHHHHHCCCCCCC		3.8421906983
205UbiquitinationMSIIRMWLGDDVKSK
HHHHHHHHCCCCCCC		3.8422817900
207UbiquitinationIIRMWLGDDVKSKDY
HHHHHHCCCCCCCCE		56.19-
207UbiquitinationIIRMWLGDDVKSKDY
HHHHHHCCCCCCCCE		56.1922817900
210UbiquitinationMWLGDDVKSKDYIVA
HHHCCCCCCCCEEEE		59.8022817900
211PhosphorylationWLGDDVKSKDYIVAL
HHCCCCCCCCEEEEE		30.5226074081
212UbiquitinationLGDDVKSKDYIVALQ
HCCCCCCCCEEEEEE		49.1622817900
222UbiquitinationIVALQHPVTTDIKHS
EEEEECCCCCCHHHH		9.3829967540
224UbiquitinationALQHPVTTDIKHSIK
EEECCCCCCHHHHHH		35.6423000965
226UbiquitinationQHPVTTDIKHSIKMF
ECCCCCCHHHHHHHH		3.9823000965
226 (in isoform 2)Ubiquitination-3.98-
227UbiquitinationHPVTTDIKHSIKMFE
CCCCCCHHHHHHHHE		33.8229967540
241UbiquitinationELTLDALISFNKRTL
EEHHHHHHHCCCCEE		4.7833845483
241 (in isoform 2)Ubiquitination-4.78-
243UbiquitinationTLDALISFNKRTLVL
HHHHHHHCCCCEEEE		11.2222817900
243 (in isoform 2)Ubiquitination-11.22-
249UbiquitinationSFNKRTLVLFPNIDA
HCCCCEEEECCCCCC		5.2421963094
254UbiquitinationTLVLFPNIDAGSKEM
EEEECCCCCCCCHHH		3.80-
254UbiquitinationTLVLFPNIDAGSKEM
EEEECCCCCCCCHHH		3.8024816145
258UbiquitinationFPNIDAGSKEMVRVM
CCCCCCCCHHHHHHH		27.4529967540
259UbiquitinationPNIDAGSKEMVRVMR
CCCCCCCHHHHHHHH		49.2424816145
263UbiquitinationAGSKEMVRVMRKKGI
CCCHHHHHHHHHCCC		18.40-
263UbiquitinationAGSKEMVRVMRKKGI
CCCHHHHHHHHHCCC		18.4029967540
265UbiquitinationSKEMVRVMRKKGIEH
CHHHHHHHHHCCCCC		3.4929967540
267UbiquitinationEMVRVMRKKGIEHHP
HHHHHHHHCCCCCCC		36.94-
268UbiquitinationMVRVMRKKGIEHHPN
HHHHHHHCCCCCCCC		55.5529967540
275UbiquitinationKGIEHHPNFRAVKHV
CCCCCCCCCCCCCCC		34.3829967540
290UbiquitinationPFDQFIQLVAHAGCM
CHHHHHHHHHHCCCE		2.9224816145
290 (in isoform 2)Ubiquitination-2.92-
299UbiquitinationAHAGCMIGNSSCGVR
HHCCCEECCCCCCCC		10.9029967540
299 (in isoform 2)Ubiquitination-10.90-
308UbiquitinationSSCGVREVGAFGTPV
CCCCCCCCCCCCCEE		4.7321963094
320PhosphorylationTPVINLGTRQIGRET
CEEEECCCCCCCCCC		23.6728857561
327PhosphorylationTRQIGRETGENVLHV
CCCCCCCCCCCEEEC		48.7322985185
330UbiquitinationIGRETGENVLHVRDA
CCCCCCCCEEECCCC		42.8933845483
337UbiquitinationNVLHVRDADTQDKIL
CEEECCCCCCHHHHH		15.93-
339UbiquitinationLHVRDADTQDKILQA
EECCCCCCHHHHHHH		40.1521963094
342UbiquitinationRDADTQDKILQALHL
CCCCCHHHHHHHHHH		35.18-
348UbiquitinationDKILQALHLQFGKQY
HHHHHHHHHHHCCCC		22.17-
353AcetylationALHLQFGKQYPCSKI
HHHHHHCCCCCCCCC		48.2026051181
353UbiquitinationALHLQFGKQYPCSKI
HHHHHHCCCCCCCCC		48.20-
354UbiquitinationLHLQFGKQYPCSKIY
HHHHHCCCCCCCCCC		48.02-
354UbiquitinationLHLQFGKQYPCSKIY
HHHHHCCCCCCCCCC		48.0221963094
359AcetylationGKQYPCSKIYGDGNA
CCCCCCCCCCCCCCH		46.8225953088
359UbiquitinationGKQYPCSKIYGDGNA
CCCCCCCCCCCCCCH		46.8221963094
370UbiquitinationDGNAVPRILKFLKSI
CCCHHHHHHHHHHHC		3.92-
370UbiquitinationDGNAVPRILKFLKSI
CCCHHHHHHHHHHHC		3.9229967540
372UbiquitinationNAVPRILKFLKSIDL
CHHHHHHHHHHHCCC		46.40-
373 (in isoform 2)Ubiquitination-10.47-
375UbiquitinationPRILKFLKSIDLQEP
HHHHHHHHHCCCCHH		48.8029967540
380UbiquitinationFLKSIDLQEPLQKKF
HHHHCCCCHHHHHCC		46.65-
380UbiquitinationFLKSIDLQEPLQKKF
HHHHCCCCHHHHHCC		46.6529967540
381UbiquitinationLKSIDLQEPLQKKFC
HHHCCCCHHHHHCCC		56.10-
381UbiquitinationLKSIDLQEPLQKKFC
HHHCCCCHHHHHCCC		56.1033845483
384 (in isoform 2)Ubiquitination-58.57-
385AcetylationDLQEPLQKKFCFPPV
CCCHHHHHCCCCCCC		56.3425953088
385UbiquitinationDLQEPLQKKFCFPPV
CCCHHHHHCCCCCCC		56.3429967540
389UbiquitinationPLQKKFCFPPVKENI
HHHHCCCCCCCCCCC		9.6133845483
390UbiquitinationLQKKFCFPPVKENIS
HHHCCCCCCCCCCCH		33.6821963094
390 (in isoform 2)Ubiquitination-33.68-
406UbiquitinationDIDHILETLSALAVD
HHHHHHHHHHHHHHH		23.6729967540
406 (in isoform 2)Ubiquitination-23.67-
416UbiquitinationALAVDLGGTNLRVAI
HHHHHCCCCCEEEEE		20.8029967540
416 (in isoform 2)Ubiquitination-20.80-
417 (in isoform 2)Ubiquitination-29.31-
435UbiquitinationGEIVKKYTQFNPKTY
CHHHHHHHCCCCCCH		35.25-
440UbiquitinationKYTQFNPKTYEERIN
HHHCCCCCCHHHHHH		65.9233845483
471UbiquitinationNCRILGVGISTGGRV
CCEEEEEEECCCCCC		13.3133845483
485UbiquitinationVNPREGIVLHSTKLI
CCCCCCEEEECCHHH		6.06-
490UbiquitinationGIVLHSTKLIQEWNS
CEEEECCHHHHHCCC		46.75-
492UbiquitinationVLHSTKLIQEWNSVD
EEECCHHHHHCCCCC		3.5829967540
497PhosphorylationKLIQEWNSVDLRTPL
HHHHHCCCCCCCCCC		20.3428857561
508UbiquitinationRTPLSDTLHLPVWVD
CCCCCCCEECCEEEC		4.7233845483
521 (in isoform 2)Ubiquitination-14.98-
522UbiquitinationDNDGNCAALAERKFG
CCCCCCHHHHHCHHC		14.9832015554
528UbiquitinationAALAERKFGQGKGLE
HHHHHCHHCCCCCHH		12.6829967540
544UbiquitinationFVTLITGTGIGGGII
EEEEEECCCCCCCEE		19.5833845483
558UbiquitinationIHQHELIHGSSFCAA
EECCCCCCCCCCHHH		42.5832015554
559UbiquitinationHQHELIHGSSFCAAE
ECCCCCCCCCCHHHH		20.2833845483
567UbiquitinationSSFCAAELGHLVVSL
CCCHHHHHCCEEEEC		4.4933845483
573UbiquitinationELGHLVVSLDGPDCS
HHCCEEEECCCCCCC		17.1733845483
581UbiquitinationLDGPDCSCGSHGCIE
CCCCCCCCCCHHHHH		9.0133845483
597UbiquitinationYASGMALQREAKKLH
HHHHHHHHHHHHHCC		31.4629967540
602UbiquitinationALQREAKKLHDEDLL
HHHHHHHHCCCCCEE		59.0929967540
613UbiquitinationEDLLLVEGMSVPKDE
CCEEEEECCCCCHHH		13.2429967540
618UbiquitinationVEGMSVPKDEAVGAL
EECCCCCHHHHHHHH		67.0733845483
627UbiquitinationEAVGALHLIQAAKLG
HHHHHHHHHHHHHHC		3.0229967540
632UbiquitinationLHLIQAAKLGNAKAQ
HHHHHHHHHCCHHHH		61.00-
632AcetylationLHLIQAAKLGNAKAQ
HHHHHHHHHCCHHHH		61.0025953088
632UbiquitinationLHLIQAAKLGNAKAQ
HHHHHHHHHCCHHHH		61.0032015554
633UbiquitinationHLIQAAKLGNAKAQS
HHHHHHHHCCHHHHH		5.6929967540
637UbiquitinationAAKLGNAKAQSILRT
HHHHCCHHHHHHHHH		51.46-
640PhosphorylationLGNAKAQSILRTAGT
HCCHHHHHHHHHHHH		28.5724719451
649UbiquitinationLRTAGTALGLGVVNI
HHHHHHHHHHHHHHH		6.1333845483
663UbiquitinationILHTMNPSLVILSGV
HHHHCCHHHHHHHHH		30.2032015554
668 (in isoform 2)Ubiquitination-18.74-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLCNE_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLCNE_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLCNE_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GABPA_HUMANGABPAphysical
22863883
KCD12_HUMANKCTD12physical
22863883
RB3GP_HUMANRAB3GAP1physical
22863883
RBGPR_HUMANRAB3GAP2physical
22863883
SMRCD_HUMANSMARCAD1physical
22863883
SEN34_HUMANTSEN34physical
22863883
GLCNE_HUMANGNEphysical
25416956
SPY2_HUMANSPRY2physical
25416956
ATL4_HUMANADAMTSL4physical
25416956
KR412_HUMANKRTAP4-12physical
25416956
KRA92_HUMANKRTAP9-2physical
25416956
GTPB3_HUMANGTPBP3physical
25416956
KR107_HUMANKRTAP10-7physical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
269921Sialuria (SIALURIA)
600737Inclusion body myopathy 2 (IBM2)
605820Nonaka myopathy (NM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLCNE_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory