TLR6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLR6_HUMAN
• UniProt AC: Q9Y2C9
• Protein Name: Toll-like receptor 6
• Gene Name: TLR6
• Organism: Homo sapiens (Human).
• Sequence Length: 796
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein . Membrane raft . Golgi apparatus . Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent
• Protein Description: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. [PubMed: 20037584 In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway]
• Protein Sequence: MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENNDVKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	PKDLPLKTKVLDMSQ CCCCCCCEEEEECCH	33.78	22210691
73	Phosphorylation	ELQVSDMSFLSELTV EEEECCCCHHHHHHH	28.20	22210691
116	Phosphorylation	HNQLQKISCHPIVSF CCCCCCCCCCCCEEE	17.26	-
144	N-linked_Glycosylation	PICKEFGNLSQLNFL HHHHHHCCHHHCCCC	41.67	UniProtKB CARBOHYD
186	N-linked_Glycosylation	RNYYIKENETESLQI HHCCCCCCCCCCEEE	57.39	UniProtKB CARBOHYD
214	N-linked_Glycosylation	SLFAIQVNISVNTLG CEEEEEEEEEECCCC	12.39	UniProtKB CARBOHYD
253	N-linked_Glycosylation	TRGSTLLNFTLNHIE CCCCCHHHHHHHHHH	30.85	UniProtKB CARBOHYD
285	N-linked_Glycosylation	VEYLNIYNLTIIESI CEEEEEEEEEEEEHH	27.23	UniProtKB CARBOHYD
359	N-linked_Glycosylation	PSTFKFLNFTQNVFT CCHHHHCCCCCCCCC	40.84	UniProtKB CARBOHYD
399	Phosphorylation	LFKVGLMTKDMPSLE HHHHCCCCCCCCCCE	29.00	29083192
423	N-linked_Glycosylation	ESGRHKENCTWVESI CCCCCCCCCCEEEEE	33.07	UniProtKB CARBOHYD
434	N-linked_Glycosylation	VESIVVLNLSSNMLT EEEEEEEECCCCCCC	26.68	UniProtKB CARBOHYD
464	Phosphorylation	LHSNKIKSVPKQVVK CCCCCCCCCCHHHHH	47.31	29496963
542	Ubiquitination	CELREFVKNIDQVSS HHHHHHHHCHHHHCH	54.21	-
583	N-linked_Glycosylation	HMSELSCNITLLIVT CHHHHCCCEEEEHHH	27.23	UniProtKB CARBOHYD
647	Phosphorylation	LQFHAFISYSEHDSA HCCEEEEECCCCCCH	19.02	-
648	Phosphorylation	QFHAFISYSEHDSAW CCEEEEECCCCCCHH	17.17	-
649	Phosphorylation	FHAFISYSEHDSAWV CEEEEECCCCCCHHH	22.97	-
653	Phosphorylation	ISYSEHDSAWVKSEL EECCCCCCHHHHHHH	26.41	-
786	Phosphorylation	AAFNMKLTLVTENND HHHCCCEEEEECCCC	17.42	-
789	Phosphorylation	NMKLTLVTENNDVKS CCCEEEEECCCCCCC	35.79	-
796	Phosphorylation	TENNDVKS------- ECCCCCCC-------	45.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLR6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLR6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLR6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TLR6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.