STX19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX19_HUMAN
• UniProt AC: Q8N4C7
• Protein Name: Syntaxin-19
• Gene Name: STX19
• Organism: Homo sapiens (Human).
• Sequence Length: 294
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Cytoplasm .
• Protein Description: Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR)..
• Protein Sequence: MKDRLQELKQRTKEIELSRDSHVSTTETEEQGVFLQQAVIYEREPVAERHLHEIQKLQESINNLADNVQKFGQQQKSLVASMRRFSLLKRESTITKEIKIQAEYINRSLNDLVKEVKKSEVENGPSSVVTRILKSQHAAMFRHFQQIMFIYNDTIAAKQEKCKTFILRQLEVAGKEMSEEDVNDMLHQGKWEVFNESLLTEINITKAQLSEIEQRHKELVNLENQIKDLRDLFIQISLLVEEQGESINNIEMTVNSTKEYVNNTKEKFGLAVKYKKRNPCRVLCCWCCPCCSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Acetylation	KDRLQELKQRTKEIE HHHHHHHHHHHHHHH	36.66	20167786
13	Ubiquitination	QELKQRTKEIELSRD HHHHHHHHHHHHCCC	59.90	-
77	Phosphorylation	KFGQQQKSLVASMRR HHHHHHHHHHHHHHH	24.60	-
81	Phosphorylation	QQKSLVASMRRFSLL HHHHHHHHHHHHHHH	12.82	-
86	Phosphorylation	VASMRRFSLLKREST HHHHHHHHHHHCCCC	30.86	24719451
99	Ubiquitination	STITKEIKIQAEYIN CCCCHHHHHHHHHHH	29.83	29901268
104	Phosphorylation	EIKIQAEYINRSLND HHHHHHHHHHHHHHH	13.40	22468782
108	Phosphorylation	QAEYINRSLNDLVKE HHHHHHHHHHHHHHH	27.34	22468782
119	Phosphorylation	LVKEVKKSEVENGPS HHHHHHHHHHHCCCC	40.95	27732954
126	Phosphorylation	SEVENGPSSVVTRIL HHHHCCCCHHHHHHH	36.84	24702127
127	Phosphorylation	EVENGPSSVVTRILK HHHCCCCHHHHHHHH	24.60	27732954
130	Phosphorylation	NGPSSVVTRILKSQH CCCCHHHHHHHHHHH	15.16	27732954
284	S-palmitoylation	RNPCRVLCCWCCPCC CCCCEEEEEEECCCC	1.23	30254024
285	S-palmitoylation	NPCRVLCCWCCPCCS CCCEEEEEEECCCCC	2.45	30254024
287	S-palmitoylation	CRVLCCWCCPCCSSK CEEEEEEECCCCCCC	0.85	30254024
288	S-palmitoylation	RVLCCWCCPCCSSK- EEEEEEECCCCCCC-	0.94	30254024
290	S-palmitoylation	LCCWCCPCCSSK--- EEEEECCCCCCC---	1.88	30254024
291	S-palmitoylation	CCWCCPCCSSK---- EEEECCCCCCC----	2.88	30254024

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STX19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
STXB1_HUMAN	STXBP1	physical	26186194
STXB2_HUMAN	STXBP2	physical	26186194
ANM3_HUMAN	PRMT3	physical	26186194
SNP23_HUMAN	SNAP23	physical	26186194
ST1A2_HUMAN	SULT1A2	physical	26186194
STB5L_HUMAN	STXBP5L	physical	26186194
STXB5_HUMAN	STXBP5	physical	26186194
TBK1_HUMAN	TBK1	physical	26186194
VAMP3_HUMAN	VAMP3	physical	26186194
VAMP2_HUMAN	VAMP2	physical	26186194
ZN277_HUMAN	ZNF277	physical	26186194
VAMP8_HUMAN	VAMP8	physical	26186194
PRPK_HUMAN	TP53RK	physical	26186194
H2A2B_HUMAN	HIST2H2AB	physical	26186194
TRIM9_HUMAN	TRIM9	physical	26186194
STXB2_HUMAN	STXBP2	physical	28514442
STXB5_HUMAN	STXBP5	physical	28514442
VAMP8_HUMAN	VAMP8	physical	28514442
STXB1_HUMAN	STXBP1	physical	28514442
STB5L_HUMAN	STXBP5L	physical	28514442
ANM3_HUMAN	PRMT3	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
ST1A2_HUMAN	SULT1A2	physical	28514442
ZN277_HUMAN	ZNF277	physical	28514442
TRIM9_HUMAN	TRIM9	physical	28514442
TBK1_HUMAN	TBK1	physical	28514442
SNP23_HUMAN	SNAP23	physical	28514442
VAMP2_HUMAN	VAMP2	physical	28514442
ZWINT_HUMAN	ZWINT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.