F110C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F110C_HUMAN
• UniProt AC: Q1W6H9
• Protein Name: Protein FAM110C
• Gene Name: FAM110C
• Organism: Homo sapiens (Human).
• Sequence Length: 321
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Nucleus . Colocalizes with microtubules during interphase (PubMed:17499476). Detected at the mitotic spindle poles
• Protein Description: May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway..
• Protein Sequence: MRALAALSAPPNERLLPRDPAATRDPDAARPARRSAVERLAADRAKYVRGRPGTGRGVASEGSGPGAIKCPGNDPGPPARAPAPVARRAIARKPLRPDSLIIYRQKCEFVRGSGADGPRASLVKKLFQGPGKDKAPVPRTGDEGKAGNPETVPTTPGPAADPAIPETPAPAARSAAPSSVPAAPPGPEPRVVRRRGLQRSQSDLSSRYSAALAESDTFFQYCGLDPEVVEALGRENFTAGSDCVTLKVRSVSVATSGSGFSRHSGGDDEGLQEEELIEQVPSTTSVIERNARIIKWLYTCKKAKETPSQEQSRTRGSKPSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	LPRDPAATRDPDAAR CCCCCCHHCCCCHHC	37.40	23403867
35	Phosphorylation	AARPARRSAVERLAA HHCHHHHHHHHHHHH	30.98	-
47	Phosphorylation	LAADRAKYVRGRPGT HHHHHHHHHCCCCCC	8.39	-
56	Methylation	RGRPGTGRGVASEGS CCCCCCCCCCCCCCC	35.93	-
93	Acetylation	ARRAIARKPLRPDSL HHHHHHCCCCCCCCE	39.11	26051181
99	Phosphorylation	RKPLRPDSLIIYRQK CCCCCCCCEEEEEEC	24.93	25394399
103	Phosphorylation	RPDSLIIYRQKCEFV CCCCEEEEEECCEEE	10.45	28122231
113	Phosphorylation	KCEFVRGSGADGPRA CCEEECCCCCCCHHH	21.90	28102081
121	Phosphorylation	GADGPRASLVKKLFQ CCCCHHHHHHHHHHC	34.67	28978645
154	Phosphorylation	GNPETVPTTPGPAAD CCCCCCCCCCCCCCC	41.09	-
155	Phosphorylation	NPETVPTTPGPAADP CCCCCCCCCCCCCCC	21.85	-
174	Phosphorylation	TPAPAARSAAPSSVP CCCCCHHHCCCCCCC	24.85	23312004
178	Phosphorylation	AARSAAPSSVPAAPP CHHHCCCCCCCCCCC	38.96	30624053
179	Phosphorylation	ARSAAPSSVPAAPPG HHHCCCCCCCCCCCC	30.94	30624053
200	Phosphorylation	RRRGLQRSQSDLSSR HHHCCCCCHHHHHHH	22.52	22617229
202	Phosphorylation	RGLQRSQSDLSSRYS HCCCCCHHHHHHHHH	41.59	25849741
205	Phosphorylation	QRSQSDLSSRYSAAL CCCHHHHHHHHHHHH	20.12	28102081
206	Phosphorylation	RSQSDLSSRYSAALA CCHHHHHHHHHHHHH	42.40	28102081
238	Phosphorylation	ALGRENFTAGSDCVT HHCCCCCCCCCCCEE	41.51	23927012
241	Phosphorylation	RENFTAGSDCVTLKV CCCCCCCCCCEEEEE	25.93	25072903
245	Phosphorylation	TAGSDCVTLKVRSVS CCCCCCEEEEEEEEE	27.48	23927012
250	Phosphorylation	CVTLKVRSVSVATSG CEEEEEEEEEEEECC	23.02	30576142
252	Phosphorylation	TLKVRSVSVATSGSG EEEEEEEEEEECCCC	13.79	28348404
255	Phosphorylation	VRSVSVATSGSGFSR EEEEEEEECCCCCCC	31.31	30576142
256	Phosphorylation	RSVSVATSGSGFSRH EEEEEEECCCCCCCC	22.63	23927012
258	Phosphorylation	VSVATSGSGFSRHSG EEEEECCCCCCCCCC	36.11	30576142
261	Phosphorylation	ATSGSGFSRHSGGDD EECCCCCCCCCCCCC	32.39	23927012
264	Phosphorylation	GSGFSRHSGGDDEGL CCCCCCCCCCCCCCC	43.28	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F110C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F110C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F110C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKT1_HUMAN	AKT1	physical	19698782
TBA1A_HUMAN	TUBA1A	physical	19698782
PTPA_HUMAN	PPP2R4	physical	19698782

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.