K1C23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C23_HUMAN
• UniProt AC: Q9C075
• Protein Name: Keratin, type I cytoskeletal 23
• Gene Name: KRT23
• Organism: Homo sapiens (Human).
• Sequence Length: 422
• Protein Sequence: MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSMKVSATPKIKAITQETINGRLVLCQVNEIQKHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MNSGHSFSQT -----CCCCCCCCCC	36.26	28348404
6	Phosphorylation	--MNSGHSFSQTPSA --CCCCCCCCCCCCC	30.07	28348404
8	Phosphorylation	MNSGHSFSQTPSASF CCCCCCCCCCCCCCC	35.84	27251275
10	Phosphorylation	SGHSFSQTPSASFHG CCCCCCCCCCCCCCC	20.29	28348404
12	Phosphorylation	HSFSQTPSASFHGAG CCCCCCCCCCCCCCC	39.68	28348404
14	Phosphorylation	FSQTPSASFHGAGGG CCCCCCCCCCCCCCC	23.32	28348404
27	Phosphorylation	GGWGRPRSFPRAPTV CCCCCCCCCCCCCEE	42.14	27251275
33	Phosphorylation	RSFPRAPTVHGGAGG CCCCCCCEECCCCCC	24.93	23312004
44	Phosphorylation	GAGGARISLSFTTRS CCCCCEEEEEEECCC	16.65	27251275
46	Phosphorylation	GGARISLSFTTRSCP CCCEEEEEEECCCCC	17.47	27251275
48	Phosphorylation	ARISLSFTTRSCPPP CEEEEEEECCCCCCC	20.23	27251275
49	Phosphorylation	RISLSFTTRSCPPPG EEEEEEECCCCCCCC	20.69	30576142
51	Phosphorylation	SLSFTTRSCPPPGGS EEEEECCCCCCCCCC	28.96	28348404
58	Phosphorylation	SCPPPGGSWGSGRSS CCCCCCCCCCCCCCC	33.89	23312004
61	Phosphorylation	PPGGSWGSGRSSPLL CCCCCCCCCCCCCCC	25.44	30576142
64	Phosphorylation	GSWGSGRSSPLLGGN CCCCCCCCCCCCCCC	39.57	26657352
65	Phosphorylation	SWGSGRSSPLLGGNG CCCCCCCCCCCCCCC	20.43	22985185
75	Phosphorylation	LGGNGKATMQNLNDR CCCCCCHHHHHHHHH	23.83	26330541
86	Phosphorylation	LNDRLASYLEKVRAL HHHHHHHHHHHHHHH	17.17	-
106	Acetylation	KLESRILKWHQQRDP HHHHHHHHHHHHCCC	40.01	7678669
116	Acetylation	QQRDPGSKKDYSQYE HHCCCCCCCCHHHHH	56.42	7678679
179	Dimethylation	EIEVEGLRRTLDNLT EEEEEHHHHHHHCEE	40.15	-
179	Methylation	EIEVEGLRRTLDNLT EEEEEHHHHHHHCEE	40.15	24410715
181	Phosphorylation	EVEGLRRTLDNLTIV EEEHHHHHHHCEEEE	31.84	-
189	Phosphorylation	LDNLTIVTTDLEQEV HHCEEEEECCHHHHH	15.67	-
190	Phosphorylation	DNLTIVTTDLEQEVE HCEEEEECCHHHHHH	27.91	-
221	Phosphorylation	MEKHHVPSDFNVNVK HHHCCCCCCCEEEEE	54.46	27251275
267	Phosphorylation	DTWYKEQSAAMSQEA HHHHHHHHHHHCHHH	21.06	-
276	Phosphorylation	AMSQEAASPATVQSR HHCHHHCCCCCHHHC	23.32	27251275
309	Phosphorylation	QTQYSTKSALENMLS HHCCCCHHHHHHHHH	37.87	28348404
316	Phosphorylation	SALENMLSETQSRYS HHHHHHHHHHHHHHC	28.03	28348404
318	Phosphorylation	LENMLSETQSRYSCK HHHHHHHHHHHHCHH	28.59	28348404
320	Phosphorylation	NMLSETQSRYSCKLQ HHHHHHHHHHCHHHH	40.37	28348404
323	Phosphorylation	SETQSRYSCKLQDMQ HHHHHHHCHHHHHHH	12.03	28348404
354	Phosphorylation	LERQNNEYQVLLGIK HHHCCCCCHHHHHHH	13.17	22817900
379	Phosphorylation	RRLLEGESEGTREES HHHHCCCCCCCCCCC	52.78	27251275
382	Phosphorylation	LEGESEGTREESKSS HCCCCCCCCCCCHHH	30.75	27251275
386	Phosphorylation	SEGTREESKSSMKVS CCCCCCCCHHHCCCC	32.84	28555341
402	Phosphorylation	TPKIKAITQETINGR CCCCEEEEEEEECCE	25.80	20068231
405	Phosphorylation	IKAITQETINGRLVL CEEEEEEEECCEEEE	15.21	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C23_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C23_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K1C23_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.