dbPTM

RHG31_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHG31_HUMAN
UniProt AC	Q2M1Z3
Protein Name	Rho GTPase-activating protein 31
Gene Name	ARHGAP31
Organism	Homo sapiens (Human).
Sequence Length	1444
Subcellular Localization	Cell projection, lamellipodium. Cell junction, focal adhesion.
Protein Description	Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration..
Protein Sequence	MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESSTLQESPRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPPLPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEATPRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQHGLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPTVKSQWTLEVPSSSSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPPNQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTSPGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDPKVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAVPVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKEEKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDNLLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPTQTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSGRQIE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
141	Phosphorylation	VIQELPPSHYRTLEY HHHHCCHHHHHHHHH	31.07	29978859
143	Phosphorylation	QELPPSHYRTLEYLI HHCCHHHHHHHHHHH	15.05	29978859
235	Phosphorylation	ENRPIMKSLTLPALS CCCCCCHHCHHHHHC	14.81	24719451
237	Phosphorylation	RPIMKSLTLPALSLP CCCCHHCHHHHHCCC	37.47	23403867
242	Phosphorylation	SLTLPALSLPMKLVS HCHHHHHCCCCEEEE	32.31	24719451
249	Phosphorylation	SLPMKLVSLEEAQAR CCCCEEEEHHHHHHH	40.26	27251275
272	Phosphorylation	RKERRENSLPEIVPP HHHHHHCCCCCCCCC	40.31	26657352
282	Phosphorylation	EIVPPMGTLFHTVLE CCCCCCHHHHHHHHH	21.72	28857561
286	Phosphorylation	PMGTLFHTVLELPDN CCHHHHHHHHHCCCC	21.32	-
306	Phosphorylation	SKSKKWKSIFNLGRS CCCHHHHHHHCCCCC	31.15	26657352
313	Phosphorylation	SIFNLGRSGSDSKSK HHHCCCCCCCCCCCH	40.63	29759185
315	Phosphorylation	FNLGRSGSDSKSKLS HCCCCCCCCCCCHHC	39.70	29759185
317	Phosphorylation	LGRSGSDSKSKLSRN CCCCCCCCCCHHCCC	40.29	29759185
326	Phosphorylation	SKLSRNGSVFVRGQR CHHCCCCCEEECCEE	18.87	24501219
335	Phosphorylation	FVRGQRLSVEKATIR EECCEECEEEEEEEC	30.35	23911959
340	Phosphorylation	RLSVEKATIRPAKSM ECEEEEEEECCCCCC	28.69	23403867
346	Phosphorylation	ATIRPAKSMDSLCSV EEECCCCCCCCCCCC	29.90	29255136
349	Phosphorylation	RPAKSMDSLCSVPVE CCCCCCCCCCCCEEC	23.72	23403867
352	Phosphorylation	KSMDSLCSVPVEGKE CCCCCCCCCEECCCC	34.45	23403867
367	Phosphorylation	TKGNFNRTVTTGGFF CCCCCCCEEEECEEE	24.25	27251275
369	Phosphorylation	GNFNRTVTTGGFFIP CCCCCEEEECEEEEE	21.07	28857561
370	Phosphorylation	NFNRTVTTGGFFIPA CCCCEEEECEEEEEE	30.85	27251275
382	Phosphorylation	IPATKMHSTGTGSSC EEEEEEECCCCCCCC	25.65	26657352
383	Phosphorylation	PATKMHSTGTGSSCD EEEEEECCCCCCCCC	24.88	29255136
385	Phosphorylation	TKMHSTGTGSSCDLT EEEECCCCCCCCCCC	33.70	26657352
387	Phosphorylation	MHSTGTGSSCDLTKQ EECCCCCCCCCCCCC	27.86	29255136
388	Phosphorylation	HSTGTGSSCDLTKQE ECCCCCCCCCCCCCC	17.00	29255136
392	Phosphorylation	TGSSCDLTKQEGEWG CCCCCCCCCCCCCCC	19.89	23403867
455	Phosphorylation	PKMLGMFYTSNDSPS CHHCCCEECCCCCCC	10.60	27080861
456	Phosphorylation	KMLGMFYTSNDSPSK HHCCCEECCCCCCCC	15.13	23090842
457	Phosphorylation	MLGMFYTSNDSPSKS HCCCEECCCCCCCCC	27.53	23090842
460	Phosphorylation	MFYTSNDSPSKSVFT CEECCCCCCCCCEEH	35.01	22199227
462	Phosphorylation	YTSNDSPSKSVFTSS ECCCCCCCCCEEHHH	41.33	27080861
464	Phosphorylation	SNDSPSKSVFTSSLF CCCCCCCCEEHHHHH	27.14	23403867
476	Phosphorylation	SLFQMEPSPRNQRKA HHHCCCCCCCCHHHC	24.16	29255136
499	Phosphorylation	VSVPLRVSAVISTNS EECCEEEEEEEECCC	15.47	23403867
503	Phosphorylation	LRVSAVISTNSTPCR EEEEEEEECCCCCCC	18.22	23403867
504	Phosphorylation	RVSAVISTNSTPCRT EEEEEEECCCCCCCC	23.28	23403867
506	Phosphorylation	SAVISTNSTPCRTPP EEEEECCCCCCCCCC	33.54	23403867
507	Phosphorylation	AVISTNSTPCRTPPK EEEECCCCCCCCCCH	28.60	23403867
511	Phosphorylation	TNSTPCRTPPKELQS CCCCCCCCCCHHHHC	51.14	23403867
518	Phosphorylation	TPPKELQSLSSLEEF CCCHHHHCCCCCCCC	42.73	27251275
520	Phosphorylation	PKELQSLSSLEEFSF CHHHHCCCCCCCCCC	37.82	28348404
521	Phosphorylation	KELQSLSSLEEFSFH HHHHCCCCCCCCCCC	45.13	28348404
526	Phosphorylation	LSSLEEFSFHGSESG CCCCCCCCCCCCCCC	21.44	27251275
530	Phosphorylation	EEFSFHGSESGGWPE CCCCCCCCCCCCCCC	21.73	27251275
532	Phosphorylation	FSFHGSESGGWPEEE CCCCCCCCCCCCCCC	44.28	27251275
589	Phosphorylation	AHLEEKKTPESSLSS CCCCCCCCCCHHHHH	43.27	27732954
592	Phosphorylation	EEKKTPESSLSSQHL CCCCCCCHHHHHHHH	37.47	27732954
593	Phosphorylation	EKKTPESSLSSQHLN CCCCCCHHHHHHHHH	30.52	23403867
595	Phosphorylation	KTPESSLSSQHLNEL CCCCHHHHHHHHHHH	29.87	23403867
596	Phosphorylation	TPESSLSSQHLNELE CCCHHHHHHHHHHHH	27.23	27732954
623	Phosphorylation	REAGEMESSTLQESP HHHCCCCCCCCCCCH	27.58	27486199
624	Phosphorylation	EAGEMESSTLQESPR HHCCCCCCCCCCCHH	21.60	27486199
625	Phosphorylation	AGEMESSTLQESPRA HCCCCCCCCCCCHHH	41.56	29255136
629	Phosphorylation	ESSTLQESPRARAEA CCCCCCCCHHHHHHH	13.51	23401153
665	Phosphorylation	QELKIIESEEELSSL HHHEECCCHHHHHCC	39.64	29507054
670	Phosphorylation	IESEEELSSLPPPAL CCCHHHHHCCCCCCC	32.86	22468782
671	Phosphorylation	ESEEELSSLPPPALK CCHHHHHCCCCCCCC	58.48	27251275
679	Phosphorylation	LPPPALKTSPIQPIL CCCCCCCCCCCHHHH	40.35	22468782
680	Phosphorylation	PPPALKTSPIQPILE CCCCCCCCCCHHHHH	20.58	28348404
688	Phosphorylation	PIQPILESSLGPFIP CCHHHHHHCCCCCCC	27.67	22468782
689	Phosphorylation	IQPILESSLGPFIPS CHHHHHHCCCCCCCC	28.15	27251275
696	Phosphorylation	SLGPFIPSEPPGSLP CCCCCCCCCCCCCCC	58.90	27251275
701	Phosphorylation	IPSEPPGSLPCGSFP CCCCCCCCCCCCCCC	34.61	27251275
706	Phosphorylation	PGSLPCGSFPAPVST CCCCCCCCCCCCCCC	34.47	27251275
712	Phosphorylation	GSFPAPVSTPLEVWT CCCCCCCCCCEEEEE	24.21	-
778	Phosphorylation	VGGPGNLSPPLPPAP ECCCCCCCCCCCCCC	28.59	26657352
789	Phosphorylation	PPAPPPPTPLEESTP CCCCCCCCCCCCCCC	46.40	-
815	O-linked_Glycosylation	DSSRKLRTDLYIDQL CCCHHHHHHHHHHHH	40.57	30620550
818	Phosphorylation	RKLRTDLYIDQLKSQ HHHHHHHHHHHHHCC	12.78	27642862
824	Phosphorylation	LYIDQLKSQDSPEIS HHHHHHHCCCCHHHH	48.05	27732954
827	Phosphorylation	DQLKSQDSPEISSLC HHHHCCCCHHHHHHC	19.45	27732954
840	Phosphorylation	LCQGEEATPRHSDKQ HCCCCCCCCCCCCCC	24.92	-
844	Phosphorylation	EEATPRHSDKQNSKN CCCCCCCCCCCCCCC	48.02	-
849	Phosphorylation	RHSDKQNSKNAASEG CCCCCCCCCCHHHCC	25.45	28674151
854	Phosphorylation	QNSKNAASEGKGCGF CCCCCHHHCCCCCCC	44.46	28674151
863	Phosphorylation	GKGCGFPSPTREVEI CCCCCCCCCCCEEEE	36.32	23403867
865	Phosphorylation	GCGFPSPTREVEIVS CCCCCCCCCEEEEEE	43.74	23403867
920	Phosphorylation	WVTSPLHSPTLKDAH CCCCCCCCCCHHHHH	27.54	24275569
944	Phosphorylation	HQLEKRLSHRPSLRQ HHHHHHHHCCCCHHH	22.83	28348404
948	Phosphorylation	KRLSHRPSLRQSHSL HHHHCCCCHHHCCCC	35.82	24719451
952	Phosphorylation	HRPSLRQSHSLDSKP CCCCHHHCCCCCCCC	14.49	30266825
954	Phosphorylation	PSLRQSHSLDSKPTV CCHHHCCCCCCCCCE	38.83	30266825
957	Phosphorylation	RQSHSLDSKPTVKSQ HHCCCCCCCCCEEEE	45.91	30266825
960	Phosphorylation	HSLDSKPTVKSQWTL CCCCCCCCEEEEEEE	44.28	30266825
971	Phosphorylation	QWTLEVPSSSSCANL EEEEECCCCCCCCCC	48.29	23403867
972	Phosphorylation	WTLEVPSSSSCANLE EEEECCCCCCCCCCC	21.87	23403867
973	Phosphorylation	TLEVPSSSSCANLET EEECCCCCCCCCCCC	33.50	23403867
974	Phosphorylation	LEVPSSSSCANLETE EECCCCCCCCCCCCC	21.13	23403867
980	Phosphorylation	SSCANLETERNSDPL CCCCCCCCCCCCCCC	43.33	27080861
1002	Methylation	EITGWDEKALRSFRE CCCCCCHHHHHHHHH	50.69	-
1035	Phosphorylation	VQPNPAETSPISLAE CCCCCCCCCCCCHHC	41.74	26657352
1036	Phosphorylation	QPNPAETSPISLAEG CCCCCCCCCCCHHCC	16.25	29255136
1039	Phosphorylation	PAETSPISLAEGKEL CCCCCCCCHHCCCCC	25.55	29255136
1048	Phosphorylation	AEGKELGTHLGHSSP HCCCCCCCCCCCCCH	26.93	23403867
1053	Phosphorylation	LGTHLGHSSPQIRQG CCCCCCCCCHHHHCC	41.75	23403867
1054	Phosphorylation	GTHLGHSSPQIRQGG CCCCCCCCHHHHCCC	18.36	23403867
1071	Phosphorylation	GPESSKESSPSVQDS CCCCCCCCCCCCCCC	51.81	23403867
1072	Phosphorylation	PESSKESSPSVQDST CCCCCCCCCCCCCCC	23.45	23403867
1074	Phosphorylation	SSKESSPSVQDSTSP CCCCCCCCCCCCCCC	34.07	23403867
1078	Phosphorylation	SSPSVQDSTSPGEHP CCCCCCCCCCCCCCC	17.44	29255136
1079	Phosphorylation	SPSVQDSTSPGEHPA CCCCCCCCCCCCCCC	47.43	29255136
1080	Phosphorylation	PSVQDSTSPGEHPAK CCCCCCCCCCCCCCE	34.55	28192239
1105	Phosphorylation	PKGKNRPSSLNLDPA CCCCCCCCCCCCCCC	44.19	-
1106	Phosphorylation	KGKNRPSSLNLDPAI CCCCCCCCCCCCCCC	24.78	-
1178	Phosphorylation	ALTGRRNSAPVSVSA HHHCCCCCCCCCHHH	31.94	29255136
1182	Phosphorylation	RRNSAPVSVSAVRTS CCCCCCCCHHHHHHH	14.86	23403867
1184	Phosphorylation	NSAPVSVSAVRTSFM CCCCCCHHHHHHHHH	17.34	23403867
1254	Phosphorylation	AKDDSPSSLESSKEE CCCCCCHHHHCCCCC	39.27	22985185
1272	Phosphorylation	QDPGAIKSSPVDATA CCCCCCCCCCCCCCC	33.49	28348404
1273	Phosphorylation	DPGAIKSSPVDATAP CCCCCCCCCCCCCCC	24.76	28348404
1312	Phosphorylation	VQCRKRMSETEPSGD HHHHHHHCCCCCCCC	45.45	23403867
1314	Phosphorylation	CRKRMSETEPSGDNL HHHHHCCCCCCCCCC	45.98	23403867
1317	Phosphorylation	RMSETEPSGDNLLSS HHCCCCCCCCCCHHH	53.17	22964224
1323	Phosphorylation	PSGDNLLSSKLERPS CCCCCCHHHHCCCCC	28.70	22964224
1324	Phosphorylation	SGDNLLSSKLERPSG CCCCCHHHHCCCCCC	41.03	22964224
1330	Phosphorylation	SSKLERPSGGSKPFH HHHCCCCCCCCCCCC	63.11	25841592
1333	Phosphorylation	LERPSGGSKPFHRSR CCCCCCCCCCCCCCC	40.45	22964224
1339	Phosphorylation	GSKPFHRSRPGRPQS CCCCCCCCCCCCCCE	33.97	24719451
1346	Phosphorylation	SRPGRPQSLILFSPP CCCCCCCEEEEECCC	21.76	27282143
1374	Phosphorylation	TDSKVLLSPIRSPTQ CCCCEEECCCCCCCC	17.70	22777824
1378	Phosphorylation	VLLSPIRSPTQTVSP EEECCCCCCCCCCCC	32.78	29514088
1380	Phosphorylation	LSPIRSPTQTVSPGL ECCCCCCCCCCCCCC	37.81	29514088
1382	Phosphorylation	PIRSPTQTVSPGLLC CCCCCCCCCCCCCCC	25.98	29514088
1384	Phosphorylation	RSPTQTVSPGLLCGE CCCCCCCCCCCCCHH	19.35	29514088
1396	Phosphorylation	CGELAENTWVTPEGV CHHHHCCCEECCCCE	16.90	28102081
1432	Phosphorylation	FYQPQRRSVILDGRS CCCCCCCEEEEECCC	18.72	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1106	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
1178	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
789	T	Phosphorylation		-
Phosphorylation on Thr-789 reduces GAP activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHG31_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ITSN1_HUMAN	ITSN1	physical	18539136

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
100300	Adams-Oliver syndrome 1 (AOS1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHG31_HUMAN

Related Literatures of Post-Translational Modification

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