FACR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FACR1_HUMAN
• UniProt AC: Q8WVX9
• Protein Name: Fatty acyl-CoA reductase 1 {ECO:0000305|PubMed:15220348}
• Gene Name: FAR1 {ECO:0000312|HGNC:HGNC:26222}
• Organism: Homo sapiens (Human).
• Sequence Length: 515
• Subcellular Localization: Peroxisome membrane ; Single-pass membrane protein .
• Protein Description: Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. [PubMed: 15220348]
• Protein Sequence: MVSIPEYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVSIPEYYEGKNVL -CCCCCCCCCCCCEE	11.06	-
11	Ubiquitination	IPEYYEGKNVLLTGA CCCCCCCCCEEECCC	31.76	-
24	Ubiquitination	GATGFLGKVLLEKLL CCCCHHHHHHHHHHH	31.68	22817900
29	Sumoylation	LGKVLLEKLLRSCPK HHHHHHHHHHHCCCC	53.44	-
29	Acetylation	LGKVLLEKLLRSCPK HHHHHHHHHHHCCCC	53.44	26051181
29	2-Hydroxyisobutyrylation	LGKVLLEKLLRSCPK HHHHHHHHHHHCCCC	53.44	-
29	Sumoylation	LGKVLLEKLLRSCPK HHHHHHHHHHHCCCC	53.44	-
29	Ubiquitination	LGKVLLEKLLRSCPK HHHHHHHHHHHCCCC	53.44	22817900
36	Ubiquitination	KLLRSCPKVNSVYVL HHHHCCCCCCEEEEE	59.38	-
47	Ubiquitination	VYVLVRQKAGQTPQE EEEEEECCCCCCHHH	43.87	24816145
51	Phosphorylation	VRQKAGQTPQERVEE EECCCCCCHHHHHHH	26.48	29083192
61	Phosphorylation	ERVEEVLSGKLFDRL HHHHHHHCCHHHHHH	38.77	29083192
63	2-Hydroxyisobutyrylation	VEEVLSGKLFDRLRD HHHHHCCHHHHHHHH	42.47	-
63	Ubiquitination	VEEVLSGKLFDRLRD HHHHHCCHHHHHHHH	42.47	23000965
78	Ubiquitination	ENPDFREKIIAINSE CCCCHHHHHHHHCCC	34.85	21906983
84	Phosphorylation	EKIIAINSELTQPKL HHHHHHCCCCCCCCC	28.06	-
87	Phosphorylation	IAINSELTQPKLALS HHHCCCCCCCCCCCC	38.48	-
90	Ubiquitination	NSELTQPKLALSEED CCCCCCCCCCCCHHH	36.25	21906983
104	Phosphorylation	DKEVIIDSTNIIFHC HCCEEEECCCEEEEE	16.97	25332170
105	Phosphorylation	KEVIIDSTNIIFHCA CCEEEECCCEEEEEE	27.04	25332170
132	Phosphorylation	VQLNVIATRQLILLA HHHHHHHHHHHHHHH	14.07	-
161	Ubiquitination	AYAYCNRKHIDEVVY HHHHHCCCCCCEEEC	30.81	21890473
175	Ubiquitination	YPPPVDPKKLIDSLE CCCCCCHHHHHHHHH	56.60	22817900
176	Ubiquitination	PPPVDPKKLIDSLEW CCCCCHHHHHHHHHH	56.94	21906983
195	Ubiquitination	LVNDITPKLIGDRPN CCCCCCHHHHCCCCC	44.05	29967540
208	Ubiquitination	PNTYIYTKALAEYVV CCCEEEHHHHHHHHH	25.16	21906983
235	Phosphorylation	RPSIVGASWKEPFPG CHHHCCCCCCCCCCC	32.52	24719451
259	Ubiquitination	GLFIAAGKGILRTIR CEEEEECCHHHHHHH	37.74	23503661
371	Phosphorylation	YDIYLRMTGRSPRMM HHHHHHHHCCCHHHH	24.02	-
374	Phosphorylation	YLRMTGRSPRMMKTI HHHHHCCCHHHHHHH	20.43	-
379	Ubiquitination	GRSPRMMKTITRLHK CCCHHHHHHHHHHHH	27.68	21890473
382	Ubiquitination	PRMMKTITRLHKAMV HHHHHHHHHHHHHHH	32.20	21890473
419	Ubiquitination	QLNPEDKKTFNIDVR HCCHHHHHCCCCCHH	71.34	33845483
422	Ubiquitination	PEDKKTFNIDVRQLH HHHHHCCCCCHHHHH	34.48	27667366
442	Ubiquitination	ENYCLGTKKYVLNEE HHHHCCCCCHHHCHH	40.07	23000965
443	Ubiquitination	NYCLGTKKYVLNEEM HHHCCCCCHHHCHHH	40.19	23000965
445	Ubiquitination	CLGTKKYVLNEEMSG HCCCCCHHHCHHHCC	6.76	23000965
446	Ubiquitination	LGTKKYVLNEEMSGL CCCCCHHHCHHHCCC	6.40	23000965
510	Phosphorylation	FLSYFRASSTMRY-- HHHHHHHHCCCCC--	23.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FACR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FACR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FACR1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FACR1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616154: Peroxisomal fatty acyl-CoA reductase 1 disorder (PFCRD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.