CO6A5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO6A5_HUMAN
• UniProt AC: A8TX70
• Protein Name: Collagen alpha-5(VI) chain
• Gene Name: COL6A5
• Organism: Homo sapiens (Human).
• Sequence Length: 2615
• Subcellular Localization: Secreted, extracellular space, extracellular matrix. Deposed in the extracellular matrix of skeletal muscle..
• Protein Description: Collagen VI acts as a cell-binding protein..
• Protein Sequence: MKILLIIFVLIIWTETLADQSPGPGPVYADVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKGRSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILVVLASAESEDEVEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFNLRTIRDLSTFSQNMTQIIKDVTKYKEGAVDADMQVHFPISCQKDSLADLVFLVDESLGTGGNLRHLQTFLENITSSMDVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKSNTGAAIDQMRRDGFSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEIVSYPPEQTISTLKSYADLETYSTKFLKKLQNEIWSQISTYAEQRNLDKTGCVDTKEADIHFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDIDLRKAIFNIKQLTGGTYTGKALDYILQIIKNGMKDRMSKVPCYLIVLTDGMSTDRVVEPAKRLRAEQITVHAVGIGAANKIELQEIAGKEERVSFGQNFDALKSIKNEVVREICAEKGCEDMKADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQFSDKTKEEFQLNRYFTQQEISDAIDRMSLINEGTLTGKALNFVGQYFTHSKGARLGAKKFLILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGDSSLVFHVENFDHLKALERKLIFRVCALHDCKRITLLDVVFVLDHSGSIKKQYQDHMINLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYSNRSAIIENLRKRRDTGGNTYTAKALKHANALFTEEHGSRIKQNVKQMLIVITDGESHDHDQLNDTALELRNKGITIFAVGVGKANQKELEGMAGNKNNTIYVDNFDKLKDVFTLVQERMCTEAPEVCHLQEADVIFLCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQFGSNYQSIIELKNSLTKTQWKTQIQNVSKSGGFPRIDFALKKVSNMFNLHAGGRRNAGVPQTLVVITSGDPRYDVADAVKTLKDLGICVLVLGIGDVYKEHLLPITGNSEKIITFQDFDKLKNVDVKKRIIREICQSCGKTNCFMDIVVGFDISTHVQGQPLFQGHPQLESYLPGILEDISSIKGVSCGAGTEAQVSLAFKVNSDQGFPAKFQIYQKAVFDSLLQVNVSGPTHLNAQFLRSLWDTFKDKSASRGQVLLIFSDGLQSESNIMLENQSDRLREAGLDALLVVSLNTTAHHEFSSFEFGKRFDYRTHLTIGMRELGKKLSQYLGNIAERTCCCTFCKCPGIPGPHGTRGLQAMKGSQGLKGSRGHRGEDGNPGVRGDTGPQGDKGIAGCPGAWGQKGLKGFSGPKGGHGDDGIDGLDGEEGCHGFPGIKGEKGDPGSQGSPGSRGAPGQYGEKGFPGDPGNPGQNNNIKGQKGSKGEQGRQGRSGQKGVQGSPSSRGSRGREGQRGLRGVSGEPGNPGPTGTLGAEGLQGPQGSQGNPGRKGEKGSQGQKGPQGSPGLMGAKGSTGRPGLLGKKGEPGLPGDLGPVGQTGQRGRQGDSGIPGYGQMGRKGVKGPRGFPGDAGQKGDIGNPGIPGGPGPKGFRGLALTVGLKGEEGSRGLPGPPGQRGIKGMAGQPVYSQCDLIRFLREHSPCWKEKCPAYPTELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTSYLIRWSDYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTYAGANVRRVAVFFSNGQTASRSSIITATMEFSALDISPTVFAFDERVFLEAFGFDNTGTFQVIPVPPNGENQTLERLRRCALCYDKCFPNACIREAFLPEDSYMDVVFLIDNSRNIAKDEFKAVKALVSSVIDNFNIASDPLISDSGDRIALLSYSPWESSRRKMGTVKTEFDFITYDNQLLMKNHIQTSFQQLNGEATIGRALLWTTENLFPETPYLRKHKVIFVVSAGENYERKEFVKMMALRAKCQGYVIFVISLGSTRKDDMEELASYPLDQHLIQLGRIHKPDLNYIAKFLKPFLYSVRRGFNQYPPPMLEDACRLINLGGENIQNDGFQFVTELQEDFLGGNGFIGQELNSGRESPFVKTEDNGSDYLVYLPSQMFEPQKLMINYEKDQKSAEIASLTSGHENYGRKEEPDHTYEPGDVSLQEYYMDVAFLIDASQRVGSDEFKEVKAFITSVLDYFHIAPTPLTSTLGDRVAVLSYSPPGYMPNTEECPVYLEFDLVTYNSIHQMKHHLQDSQQLNGDVFIGHALQWTIDNVFVGTPNLRKNKVIFVISAGETNSLDKDVLRNVSLRAKCQGYSIFVFSFGPKHNDKELEELASHPLDHHLVQLGRTHKPDWNYIIKFVKPFVHLIRRAINKYPTEDMKATCVNMTSPNPENGGTENTVLLLPGIYEIKTENGDLFDEFDSQAQHLLVLGNNHSSGSETATDLMQKLYLLFSTEKLAMKDKEKAHLEEISALVVDKQQEKEDKEMEATDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	KSFPFVKTFINKMIN CCCHHHHHHHHHHHH	25.17	-
59	Phosphorylation	FINKMINSLPIEANK HHHHHHHHCCCCCCH	25.29	-
67	Phosphorylation	LPIEANKYRVALAQY CCCCCCHHEEEEEEC	15.32	-
166	Phosphorylation	KDGVKIISVGVQKAS HCCCEEEEEEEHHCC	19.11	22210691
173	Phosphorylation	SVGVQKASEENLKAM EEEEHHCCHHHHHHH	53.10	22210691
182	Phosphorylation	ENLKAMATSHFHFNL HHHHHHHHCCCCCHH	15.06	27174698
183	Phosphorylation	NLKAMATSHFHFNLR HHHHHHHCCCCCHHH	18.02	27174698
191	Phosphorylation	HFHFNLRTIRDLSTF CCCCHHHHHHHHHHH	24.43	27174698
196	Phosphorylation	LRTIRDLSTFSQNMT HHHHHHHHHHCHHHH	31.53	27174698
197	Phosphorylation	RTIRDLSTFSQNMTQ HHHHHHHHHCHHHHH	34.30	27174698
199	Phosphorylation	IRDLSTFSQNMTQII HHHHHHHCHHHHHHH	22.27	27174698
201	N-linked_Glycosylation	DLSTFSQNMTQIIKD HHHHHCHHHHHHHHH	33.98	UniProtKB CARBOHYD
203	Phosphorylation	STFSQNMTQIIKDVT HHHCHHHHHHHHHHH	24.94	27174698
228	Phosphorylation	MQVHFPISCQKDSLA EEEECCCCCCCCCHH	15.67	-
260	N-linked_Glycosylation	HLQTFLENITSSMDV HHHHHHHHHHCCCCH	45.01	UniProtKB CARBOHYD
280	Phosphorylation	RLGLMSYSNSAKTIS HHCCCHHCCCHHHHH	19.59	22210691
287	Phosphorylation	SNSAKTISFLKSSTT CCCHHHHHHHHCCCC	29.74	24719451
306	Phosphorylation	QQQIKNLSIQVGKSN HHHHHHCCEEECCCC	21.99	-
312	Phosphorylation	LSIQVGKSNTGAAID CCEEECCCCCCHHHH	33.42	-
314	Phosphorylation	IQVGKSNTGAAIDQM EEECCCCCCHHHHHH	34.98	-
386	Phosphorylation	TQLEEIVSYPPEQTI CCHHHHHCCCCHHHH	37.27	-
387	Phosphorylation	QLEEIVSYPPEQTIS CHHHHHCCCCHHHHH	16.35	-
419	Phosphorylation	KLQNEIWSQISTYAE HHHHHHHHHHHHHHH	24.25	-
422	Phosphorylation	NEIWSQISTYAEQRN HHHHHHHHHHHHHCC	14.02	-
423	Phosphorylation	EIWSQISTYAEQRNL HHHHHHHHHHHHCCC	28.51	-
424	Phosphorylation	IWSQISTYAEQRNLD HHHHHHHHHHHCCCC	11.01	-
520	Phosphorylation	KQLTGGTYTGKALDY HHHHCCCCHHHHHHH	19.44	28555341
835	N-linked_Glycosylation	QYQDHMINLTIHLVK HHHHHHHHEEEEEHH	24.45	UniProtKB CARBOHYD
887	Phosphorylation	NLRKRRDTGGNTYTA HHHHHCCCCCCHHHH	45.22	22985185
1409	Acetylation	TRGLQAMKGSQGLKG HHHHHHHCCCCCCCC	59.43	19818975
1411	Phosphorylation	GLQAMKGSQGLKGSR HHHHHCCCCCCCCCC	18.63	-
1415	Ubiquitination	MKGSQGLKGSRGHRG HCCCCCCCCCCCCCC	62.76	-
1547	Phosphorylation	GQKGVQGSPSSRGSR CCCCCCCCCCCCCCC	12.43	28634120
1553	Phosphorylation	GSPSSRGSRGREGQR CCCCCCCCCCCCCCC	30.37	28634120
1610	Phosphorylation	GQKGPQGSPGLMGAK CCCCCCCCCCCCCCC	15.56	23532336
1808	Phosphorylation	VAMVSYNSGTSYLIR EEEEEECCCCEEEEE	34.90	24719451
1817	Phosphorylation	TSYLIRWSDYNRKKQ CEEEEECHHHHHHHH	21.99	24719451
1819	Phosphorylation	YLIRWSDYNRKKQLL EEEECHHHHHHHHHH	16.02	24719451
1830	Phosphorylation	KQLLQQLSQIKYQDT HHHHHHHHCCCCCCC	26.06	24719451
1971	Phosphorylation	VVFLIDNSRNIAKDE EEEEEECCCCCCHHH	23.98	24719451
2255	Phosphorylation	NYEKDQKSAEIASLT ECCCCHHHHHHHHHC	26.04	23312004
2260	Phosphorylation	QKSAEIASLTSGHEN HHHHHHHHHCCCCCC	37.53	22210691
2262	Phosphorylation	SAEIASLTSGHENYG HHHHHHHCCCCCCCC	30.11	22210691
2263	Phosphorylation	AEIASLTSGHENYGR HHHHHHCCCCCCCCC	43.37	22210691
2414	Phosphorylation	NKVIFVISAGETNSL CEEEEEEECCCCCCC	25.56	-
2418	Phosphorylation	FVISAGETNSLDKDV EEEECCCCCCCCHHH	29.23	-
2448	Acetylation	FVFSFGPKHNDKELE EEEEECCCCCHHHHH	56.25	7712221
2459	Phosphorylation	KELEELASHPLDHHL HHHHHHHCCCCCHHH	37.96	28787133
2509	N-linked_Glycosylation	DMKATCVNMTSPNPE HHCCEEEECCCCCCC	30.11	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO6A5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO6A5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO6A5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CO6A5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.