dbPTM

DOC10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DOC10_HUMAN
UniProt AC	Q96BY6
Protein Name	Dedicator of cytokinesis protein 10 {ECO:0000305}
Gene Name	DOCK10 {ECO:0000312\|HGNC:HGNC:23479}
Organism	Homo sapiens (Human).
Sequence Length	2186
Subcellular Localization	Nucleus . Cytoplasm . Cell projection, dendritic spine .
Protein Description	Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression..
Protein Sequence	MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRRSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMERLNLFSLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNIEPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHIKGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSDYRRADRISKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMSFLPIILNQLFKVLVQNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKERTVHEELAKNVTGLLKSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSSGDLKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQTHQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVMNEQITGRDDLSKRGVDQTCTRVISKATPALPTVSISSSAEV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GERTRRFTRSLLRPG CHHHHHHHHHHCCCC	19.96	-
12	Phosphorylation	RTRRFTRSLLRPGQA HHHHHHHHHCCCCCH	28.79	23401153
13 (in isoform 3)	Phosphorylation	-	4.19	30131370
25	Phosphorylation	QAAELRHSAASAAAV CHHHHHHHHHHHHHH	21.06	23312004
28	Phosphorylation	ELRHSAASAAAVAVS HHHHHHHHHHHHHHH	20.39	23312004
34 (in isoform 3)	Phosphorylation	-	4.25	28634298
35 (in isoform 3)	Phosphorylation	-	15.29	26657352
38	Ubiquitination	AVAVSSRQQQRQEKP HHHHHHHHHHHHHCC	45.78	29967540
127	Phosphorylation	WHVVNYKYEQYSGDI CEEEEEEEEECCCCC	9.63	-
130	Phosphorylation	VNYKYEQYSGDIRQL EEEEEEECCCCCCCC	11.59	-
131	Phosphorylation	NYKYEQYSGDIRQLP EEEEEECCCCCCCCC	29.68	-
149	Phosphorylation	YKPEKLPSHSFEIDH CCCCCCCCCCEECCC	42.05	23312004
151	Phosphorylation	PEKLPSHSFEIDHED CCCCCCCCEECCCCC	28.98	23312004
165	Phosphorylation	DADKDEDTTSHSSSK CCCCCCCCCCCCCCC	28.31	28270605
166	Phosphorylation	ADKDEDTTSHSSSKG CCCCCCCCCCCCCCC	36.44	28270605
167	Phosphorylation	DKDEDTTSHSSSKGG CCCCCCCCCCCCCCC	24.38	30108239
169	Phosphorylation	DEDTTSHSSSKGGGG CCCCCCCCCCCCCCC	35.75	28270605
170	Phosphorylation	EDTTSHSSSKGGGGA CCCCCCCCCCCCCCC	30.55	28270605
171	Phosphorylation	DTTSHSSSKGGGGAG CCCCCCCCCCCCCCC	38.03	28270605
195	Phosphorylation	LYKGNFNSTVNNTVT EEECCCCCCCCCEEE	29.60	29255136
196	Phosphorylation	YKGNFNSTVNNTVTV EECCCCCCCCCEEEE	28.49	23401153
200	Phosphorylation	FNSTVNNTVTVRSFK CCCCCCCEEEEEEEC	16.61	25072903
202	Phosphorylation	STVNNTVTVRSFKKR CCCCCEEEEEEECHH	14.25	26074081
205	Phosphorylation	NNTVTVRSFKKRYFQ CCEEEEEEECHHEEE	36.76	-
214	Phosphorylation	KKRYFQLTQLPDNSY CHHEEEEEECCCCCE	19.78	30576142
220	Phosphorylation	LTQLPDNSYIMNFYK EEECCCCCEECEECC	24.34	30576142
221	Phosphorylation	TQLPDNSYIMNFYKD EECCCCCEECEECCC	15.50	-
249	Ubiquitination	DSCTGVVQNNRLRKY ECCCCHHHCCHHHHH	38.79	-
255	Ubiquitination	VQNNRLRKYAFELKM HHCCHHHHHEEEECC	45.59	-
256	Phosphorylation	QNNRLRKYAFELKMN HCCHHHHHEEEECCC	15.30	30622161
292	Phosphorylation	LNRILQISPEGPLQG HHHHHHCCCCCCCCC	12.16	23403867
302	Phosphorylation	GPLQGRRSTELTDLG CCCCCCCCCCCCCCC	25.52	26657352
303	Phosphorylation	PLQGRRSTELTDLGL CCCCCCCCCCCCCCC	32.95	28348404
306	Phosphorylation	GRRSTELTDLGLDSL CCCCCCCCCCCCCCC	23.97	28450419
312	Phosphorylation	LTDLGLDSLDNSVTC CCCCCCCCCCCCCEE	42.54	26552605
316	Phosphorylation	GLDSLDNSVTCECTP CCCCCCCCCEEECCC	20.62	26552605
318	Phosphorylation	DSLDNSVTCECTPEE CCCCCCCEEECCCCC	11.47	26552605
322	Phosphorylation	NSVTCECTPEETDSS CCCEEECCCCCCCCC	16.08	26552605
326	Phosphorylation	CECTPEETDSSENNL EECCCCCCCCCCCCC	39.25	26552605
328	Phosphorylation	CTPEETDSSENNLHA CCCCCCCCCCCCCCH	47.15	26552605
329	Phosphorylation	TPEETDSSENNLHAD CCCCCCCCCCCCCHH	47.34	26552605
343	Ubiquitination	DFAKYLTETEDTVKT HHHHHHHCCCCHHHH	47.83	-
343	Ubiquitination	DFAKYLTETEDTVKT HHHHHHHCCCCHHHH	47.83	29967540
349	Ubiquitination	TETEDTVKTTRNMER HCCCCHHHHCCCHHH	46.39	29967540
364	Ubiquitination	LNLFSLDPDIDTLKL HCCCCCCCCCCHHHC	45.83	-
364	Ubiquitination	LNLFSLDPDIDTLKL HCCCCCCCCCCHHHC	45.83	29967540
368	Phosphorylation	SLDPDIDTLKLQKKD CCCCCCCHHHCCHHC	26.57	28060719
368	Ubiquitination	SLDPDIDTLKLQKKD CCCCCCCHHHCCHHC	26.57	29967540
370	Ubiquitination	DPDIDTLKLQKKDLL CCCCCHHHCCHHCCC	51.47	29967540
374	Ubiquitination	DTLKLQKKDLLEPES CHHHCCHHCCCCCHH	40.42	29967540
378	Ubiquitination	LQKKDLLEPESVIKP CCHHCCCCCHHHCHH	55.08	-
378	Ubiquitination	LQKKDLLEPESVIKP CCHHCCCCCHHHCHH	55.08	29967540
383	Ubiquitination	LLEPESVIKPFEEKA CCCCHHHCHHHHHHH	6.98	29967540
384	Ubiquitination	LEPESVIKPFEEKAA CCCHHHCHHHHHHHH	41.31	29967540
389	Acetylation	VIKPFEEKAAKRIMI HCHHHHHHHHHHHHH	46.58	25953088
389	Ubiquitination	VIKPFEEKAAKRIMI HCHHHHHHHHHHHHH	46.58	29967540
435	Phosphorylation	ALYDLRDSRKISADF EEEECCCCCCCCCCE	29.10	24825855
475	Ubiquitination	DTITPRQSEEPHIKG CCCCCCCCCCCCCCC	45.25	29967540
481	Ubiquitination	QSEEPHIKGLPEEWL CCCCCCCCCCCHHHH	51.89	29967540
483	Ubiquitination	EEPHIKGLPEEWLKF CCCCCCCCCHHHHHC	4.02	-
489	Ubiquitination	GLPEEWLKFPKQAVF CCCHHHHHCCHHHEE	61.77	-
522	Ubiquitination	LMGNIASGAEPYIKN HHCCCCCCCCCCCCC	25.57	-
526	Phosphorylation	IASGAEPYIKNPDSN CCCCCCCCCCCCCCH	18.94	-
528	Ubiquitination	SGAEPYIKNPDSNKY CCCCCCCCCCCCHHH	57.49	-
532	Phosphorylation	PYIKNPDSNKYAQKI CCCCCCCCHHHHHHH	36.16	22210691
532	Ubiquitination	PYIKNPDSNKYAQKI CCCCCCCCHHHHHHH	36.16	29967540
538	Ubiquitination	DSNKYAQKILKSNRQ CCHHHHHHHHHHHHH	41.66	29967540
590	Ubiquitination	RQESSKISTEDLVKL HCCCCCCCHHHHHHH	29.49	29967540
596	Ubiquitination	ISTEDLVKLVSDYRR CCHHHHHHHHHHHHH	50.93	29967540
601	Phosphorylation	LVKLVSDYRRADRIS HHHHHHHHHHHHHHH	8.42	-
674	Ubiquitination	PYRVYKNQIYIYPKH EEEEECCEEEEECCC	26.22	29967540
678	Phosphorylation	YKNQIYIYPKHLKYD ECCEEEEECCCCCCC	6.83	24114839
680	Ubiquitination	NQIYIYPKHLKYDSQ CEEEEECCCCCCCHH	44.60	29967540
682	Ubiquitination	IYIYPKHLKYDSQKC EEEECCCCCCCHHHH	7.40	29967540
684	Phosphorylation	IYPKHLKYDSQKCFN EECCCCCCCHHHHHH	27.47	28961369
686	Phosphorylation	PKHLKYDSQKCFNKA CCCCCCCHHHHHHHC	28.57	28961369
688	Ubiquitination	HLKYDSQKCFNKARN CCCCCHHHHHHHCCC	44.75	29967540
697	Phosphorylation	FNKARNITVCIEFKN HHHCCCEEEEEEECC	16.93	29391485
765	Phosphorylation	HHILFSFYHVTCDIN CEEEEEEEEEHHHCC	8.32	-
821	Ubiquitination	PPNYLSFQDSASGKH CCCEECHHCCCCCCC	40.13	29967540
827	Ubiquitination	FQDSASGKHGGSDIK HHCCCCCCCCCCCCE	36.26	29967540
828	Acetylation	QDSASGKHGGSDIKW HCCCCCCCCCCCCEE	49.74	-
828	Acetylation	QDSASGKHGGSDIKW HCCCCCCCCCCCCEE	49.74	19608861
828	Ubiquitination	QDSASGKHGGSDIKW HCCCCCCCCCCCCEE	49.74	33845483
834	Acetylation	KHGGSDIKWVDGGKP CCCCCCCEEECCCEE	46.27	19608861
834	Malonylation	KHGGSDIKWVDGGKP CCCCCCCEEECCCEE	46.27	26320211
834	Ubiquitination	KHGGSDIKWVDGGKP CCCCCCCEEECCCEE	46.27	33845483
847	Ubiquitination	KPLFKVSTFVVSTVN EECEEEEEEEEEECC	24.36	33845483
875	Phosphorylation	QKREKDMSQSPTSNF HHHHHHHCCCCCHHH	37.33	23401153
877	Phosphorylation	REKDMSQSPTSNFIR HHHHHCCCCCHHHHH	23.88	23401153
879	Phosphorylation	KDMSQSPTSNFIRSC HHHCCCCCHHHHHHH	41.36	29255136
880	Phosphorylation	DMSQSPTSNFIRSCK HHCCCCCHHHHHHHH	32.88	23403867
881	Ubiquitination	MSQSPTSNFIRSCKN HCCCCCHHHHHHHHH	38.55	29967540
887	Ubiquitination	SNFIRSCKNLLNVEK HHHHHHHHHCCCHHH	52.45	29967540
947	Phosphorylation	QLDHSVQSYIKFVFK HCCHHHHHHHHHHHH	27.03	22964224
948	Ubiquitination	LDHSVQSYIKFVFKT CCHHHHHHHHHHHHC	7.34	-
954	Ubiquitination	SYIKFVFKTRACKER HHHHHHHHCCCCCCC	31.62	-
963	Ubiquitination	RACKERTVHEELAKN CCCCCCHHHHHHHHH	7.19	29967540
969	Ubiquitination	TVHEELAKNVTGLLK HHHHHHHHHHHHHCC	65.65	29967540
970	Ubiquitination	VHEELAKNVTGLLKS HHHHHHHHHHHHCCC	30.86	29967540
972	Phosphorylation	EELAKNVTGLLKSND HHHHHHHHHHCCCCC	31.35	28060719
976	Ubiquitination	KNVTGLLKSNDSTTV HHHHHHCCCCCCCHH	52.86	29967540
1000	O-linked_Glycosylation	FFAIILKSMAQHLID HHHHHHHHHHHHHHC	18.86	30379171
1035	Phosphorylation	DNLVMVLSDHVIWKY HHHHHHHHHHHHHHH	17.79	22210691
1085	Phosphorylation	NYISMFSSGDLKTLC HHHHHCCCCCHHHHH	25.68	-
1203	Phosphorylation	RKQAQIASLYMPLYG HHHHHHHHHHHHHHH	22.97	29978859
1205	Phosphorylation	QAQIASLYMPLYGML HHHHHHHHHHHHHHH	8.32	29978859
1209	Phosphorylation	ASLYMPLYGMLLDNM HHHHHHHHHHHHHCC	8.46	29978859
1225	Phosphorylation	RIYLKDLYPFTVNTS CEEECCCCCEEEECC	13.36	27080861
1228	Phosphorylation	LKDLYPFTVNTSNQG ECCCCCEEEECCCCC	14.35	23663014
1231	Phosphorylation	LYPFTVNTSNQGSRD CCCEEEECCCCCCCC	25.39	29255136
1232	Phosphorylation	YPFTVNTSNQGSRDD CCEEEECCCCCCCCC	23.19	29255136
1236	Phosphorylation	VNTSNQGSRDDLSTN EECCCCCCCCCCCCC	23.83	28348404
1241	Phosphorylation	QGSRDDLSTNGGFQS CCCCCCCCCCCCHHH	27.16	28450419
1242	Phosphorylation	GSRDDLSTNGGFQSQ CCCCCCCCCCCHHHH	45.22	30576142
1248	Phosphorylation	STNGGFQSQTAIKHA CCCCCHHHHHHHHHC	27.51	28450419
1250	Phosphorylation	NGGFQSQTAIKHANS CCCHHHHHHHHHCCC	35.28	27732954
1257	Phosphorylation	TAIKHANSVDTSFSK HHHHHCCCCCCCCCH	23.35	23401153
1260	Phosphorylation	KHANSVDTSFSKDVL HHCCCCCCCCCHHHH	29.52	29255136
1261	Phosphorylation	HANSVDTSFSKDVLN HCCCCCCCCCHHHHH	24.06	29255136
1263	Phosphorylation	NSVDTSFSKDVLNSI CCCCCCCCHHHHHHH	27.93	23403867
1274	Phosphorylation	LNSIAAFSSIAISTV HHHHHHHHHHHHHHC	18.99	30301811
1275	Phosphorylation	NSIAAFSSIAISTVN HHHHHHHHHHHHHCC	15.02	30301811
1279	Phosphorylation	AFSSIAISTVNHADS HHHHHHHHHCCCCCC	19.79	30301811
1280	Phosphorylation	FSSIAISTVNHADSR HHHHHHHHCCCCCCC	21.15	30301811
1286	Phosphorylation	STVNHADSRASLASL HHCCCCCCCCHHHHC	30.45	30301811
1289	Phosphorylation	NHADSRASLASLDSN CCCCCCCHHHHCCCC	24.29	30266825
1292	Phosphorylation	DSRASLASLDSNPST CCCCHHHHCCCCCCC	37.69	29255136
1295	Phosphorylation	ASLASLDSNPSTNEK CHHHHCCCCCCCCCC	56.80	23401153
1298	Phosphorylation	ASLDSNPSTNEKSSE HHCCCCCCCCCCCCC	48.38	30266825
1299	Phosphorylation	SLDSNPSTNEKSSEK HCCCCCCCCCCCCCC	48.96	30266825
1303	Phosphorylation	NPSTNEKSSEKTDNC CCCCCCCCCCCCCCC	37.24	26270265
1304	Phosphorylation	PSTNEKSSEKTDNCE CCCCCCCCCCCCCCC	54.93	26270265
1312	Phosphorylation	EKTDNCEKIPRPLSL CCCCCCCCCCCCHHH	61.28	32142685
1318	O-linked_Glycosylation	EKIPRPLSLIGSTLR CCCCCCHHHCCCCCC	22.18	30379171
1318	Phosphorylation	EKIPRPLSLIGSTLR CCCCCCHHHCCCCCC	22.18	30266825
1322	Phosphorylation	RPLSLIGSTLRFDKL CCHHHCCCCCCCCCC	19.78	30266825
1323	Phosphorylation	PLSLIGSTLRFDKLD CHHHCCCCCCCCCCC	19.42	29255136
1331	Phosphorylation	LRFDKLDQAETRSLL CCCCCCCHHHHHHHH	52.08	32142685
1350	Phosphorylation	HIMKTISYETLIAYW HHHHHCCHHHHHHHH	14.75	-
1400	Phosphorylation	AAFKFVQSTQNNGTL HHHHHHHHCCCCCCC	27.02	28450419
1401	Phosphorylation	AFKFVQSTQNNGTLK HHHHHHHCCCCCCCC	20.44	28450419
1406	Phosphorylation	QSTQNNGTLKGSNPS HHCCCCCCCCCCCCC	27.67	29255136
1410	Phosphorylation	NNGTLKGSNPSCQTS CCCCCCCCCCCHHHH	43.94	-
1413	Phosphorylation	TLKGSNPSCQTSGLL CCCCCCCCHHHHHHH	24.09	-
1438	Phosphorylation	EGHKQHRSQTLPIIR CCCCHHHCCCCHHHC	25.95	30266825
1440	Phosphorylation	HKQHRSQTLPIIRGK CCHHHCCCCHHHCCC	35.43	23401153
1441	Ubiquitination	KQHRSQTLPIIRGKN CHHHCCCCHHHCCCC	1.91	29967540
1447	Ubiquitination	TLPIIRGKNALSNPK CCHHHCCCCCCCCHH	29.24	29967540
1451	Phosphorylation	IRGKNALSNPKLLQM HCCCCCCCCHHHHHH	48.99	30576142
1513	Phosphorylation	QQCDCQNSLMKRVFD HHCCCCCHHHHHHHH	12.17	28122231
1516	Acetylation	DCQNSLMKRVFDTYM CCCCHHHHHHHHHHH	51.18	26051181
1521	Phosphorylation	LMKRVFDTYMLFFQV HHHHHHHHHHHHEEC	10.20	28122231
1522	Phosphorylation	MKRVFDTYMLFFQVN HHHHHHHHHHHEECC	8.15	28122231
1531	Phosphorylation	LFFQVNQSATALKHV HHEECCCHHHHHHHH	23.53	28122231
1533	Phosphorylation	FQVNQSATALKHVFA EECCCHHHHHHHHHH	37.46	28122231
1587	Acetylation	QTEASALLYFFMRKN HHHHHHHHHHHHHHC	3.33	19608861
1593	Acetylation	LLYFFMRKNFEFNKQ HHHHHHHHCCCHHHH	54.95	19608861
1593	Malonylation	LLYFFMRKNFEFNKQ HHHHHHHHCCCHHHH	54.95	26320211
1602	Phosphorylation	FEFNKQKSIVRSHLQ CCHHHHHHHHHHHHH	24.67	19764811
1649	Ubiquitination	DKQMKNSNFPAEVKD CCCCCCCCCCHHHHH	57.21	29967540
1655	Ubiquitination	SNFPAEVKDLTKRIR CCCCHHHHHHHHHHH	38.23	29967540
1658	Phosphorylation	PAEVKDLTKRIRTVL CHHHHHHHHHHHHHH	28.54	22468782
1663	Phosphorylation	DLTKRIRTVLMATAQ HHHHHHHHHHHHHHH	18.67	21406692
1668	Phosphorylation	IRTVLMATAQMKEHE HHHHHHHHHHHHHHC	11.94	21406692
1695	Phosphorylation	LANSYASTPELRRTW HHHCCCCCHHHHHHH	16.77	24719451
1853	Phosphorylation	FKKLSDLYYDIHRSY HHHHHHHHHHHHHHH	12.23	-
1854	Phosphorylation	KKLSDLYYDIHRSYL HHHHHHHHHHHHHHH	18.73	25147952
1865	Ubiquitination	RSYLKVAEVVNSEKR HHHHHHHHHHCCCCH	50.41	30230243
1869	Phosphorylation	KVAEVVNSEKRLFGR HHHHHHCCCCHHHCE	32.65	-
1871	2-Hydroxyisobutyrylation	AEVVNSEKRLFGRYY HHHHCCCCHHHCEEE	54.98	-
1871	Ubiquitination	AEVVNSEKRLFGRYY HHHHCCCCHHHCEEE	54.98	30230243
1884	Ubiquitination	YYRVAFYGQGFFEEE EEEEEEECCCCEECC	18.06	30230243
1896	Ubiquitination	EEEEGKEYIYKEPKL ECCCCCEEEECCCCC	17.03	29967540
1902	Ubiquitination	EYIYKEPKLTGLSEI EEEECCCCCCCHHHH	60.83	29967540
1914	Ubiquitination	SEISQRLLKLYADKF HHHHHHHHHHHHHHH	3.80	-
1914	Ubiquitination	SEISQRLLKLYADKF HHHHHHHHHHHHHHH	3.80	29967540
1917	Phosphorylation	SQRLLKLYADKFGAD HHHHHHHHHHHHCCC	15.92	-
1920	Ubiquitination	LLKLYADKFGADNVK HHHHHHHHHCCCCEE	37.21	29967540
1928	Ubiquitination	FGADNVKIIQDSNKV HCCCCEEEECCCCCC	2.73	29967540
1932	Phosphorylation	NVKIIQDSNKVNPKD CEEEECCCCCCCHHH	23.36	23898821
1934	Ubiquitination	KIIQDSNKVNPKDLD EEECCCCCCCHHHCC	47.55	29967540
1944	Phosphorylation	PKDLDPKYAYIQVTY HHHCCCCCEEEEEEE	15.27	26657352
1946	Phosphorylation	DLDPKYAYIQVTYVT HCCCCCEEEEEEEEC	6.70	26657352
1950	Phosphorylation	KYAYIQVTYVTPFFE CCEEEEEEEECCCCC	8.90	24043423
1951	Phosphorylation	YAYIQVTYVTPFFEE CEEEEEEEECCCCCH	11.94	26657352
1953	Phosphorylation	YIQVTYVTPFFEEKE EEEEEEECCCCCHHH	12.17	24043423
1959	Ubiquitination	VTPFFEEKEIEDRKT ECCCCCHHHHCCCCC	57.71	29967540
1965	Ubiquitination	EKEIEDRKTDFEMHH HHHHCCCCCCHHHCC	65.84	29967540
1983	Ubiquitination	RFVFETPFTLSGKKH CEEEECCCCCCCCCC	16.33	-
1986	Phosphorylation	FETPFTLSGKKHGGV EECCCCCCCCCCCCH	45.57	28348404
1989	Ubiquitination	PFTLSGKKHGGVAEQ CCCCCCCCCCCHHHH	51.51	-
2001	Phosphorylation	AEQCKRRTILTTSHL HHHHCCCEEEEHHHH	25.11	26552605
2004	Phosphorylation	CKRRTILTTSHLFPY HCCCEEEEHHHHHHH	23.54	26552605
2005	Phosphorylation	KRRTILTTSHLFPYV CCCEEEEHHHHHHHH	15.65	26552605
2006	Phosphorylation	RRTILTTSHLFPYVK CCEEEEHHHHHHHHH	16.98	26552605
2011	Phosphorylation	TTSHLFPYVKKRIQV EHHHHHHHHHHHHHE	19.98	26552605
2020	Phosphorylation	KKRIQVISQSSTELN HHHHHEEECCCCCCC	25.75	-
2022	Phosphorylation	RIQVISQSSTELNPI HHHEEECCCCCCCCH	32.22	28348404
2023	Phosphorylation	IQVISQSSTELNPIE HHEEECCCCCCCCHH	20.47	28348404
2024	Phosphorylation	QVISQSSTELNPIEV HEEECCCCCCCCHHH	50.14	28348404
2037	Phosphorylation	EVAIDEMSKKVSELN HHHHHHHHHHHHHHH	27.55	-
2076	Phosphorylation	VNAGPMAYARAFLEE EECCHHHHHHHHHHH	7.14	18083107
2084	Phosphorylation	ARAFLEETNAKKYPD HHHHHHHHCCHHCCH	30.97	-
2084	Ubiquitination	ARAFLEETNAKKYPD HHHHHHHHCCHHCCH	30.97	24816145
2089	Ubiquitination	EETNAKKYPDNQVKL HHHCCHHCCHHHHHH	18.34	29967540
2095	Ubiquitination	KYPDNQVKLLKEIFR HCCHHHHHHHHHHHH	38.04	29967540
2114	Ubiquitination	ACGQALDVNERLIKE HHCCCCCHHHHHHHH	9.25	-
2114	Ubiquitination	ACGQALDVNERLIKE HHCCCCCHHHHHHHH	9.25	24816145
2118	Ubiquitination	ALDVNERLIKEDQLE CCCHHHHHHHHHHHH	5.52	24816145
2120	Ubiquitination	DVNERLIKEDQLEYQ CHHHHHHHHHHHHHH	60.88	24816145
2124	Ubiquitination	RLIKEDQLEYQEELR HHHHHHHHHHHHHHH	11.64	24816145
2126	Phosphorylation	IKEDQLEYQEELRSH HHHHHHHHHHHHHHH	29.80	27642862
2129	Ubiquitination	DQLEYQEELRSHYKD HHHHHHHHHHHHHHH	33.68	29967540
2133	Ubiquitination	YQEELRSHYKDMLSE HHHHHHHHHHHHHHH	27.51	24816145
2135	Ubiquitination	EELRSHYKDMLSELS HHHHHHHHHHHHHHH	31.10	29967540
2150	Phosphorylation	TVMNEQITGRDDLSK HHHHHCCCCCHHHHH	26.34	-
2169	O-linked_Glycosylation	QTCTRVISKATPALP HHHHHHHHHCCCCCC	17.24	30379171
2183	Phosphorylation	PTVSISSSAEV---- CEEEECCCCCC----	22.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DOC10_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DOC10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DOC10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LURA1_HUMAN	LURAP1	physical	16189514
DOCK9_HUMAN	DOCK9	physical	28514442
HUTH_HUMAN	HAL	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DOC10_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-834 AND LYS-1593, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1232; SER-1257;SER-1292; SER-1295; SER-1318; THR-1406 AND THR-1440, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-200; SER-1292 ANDSER-1295, AND MASS SPECTROMETRY.	18088087 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1292; SER-1295 ANDSER-1318, AND MASS SPECTROMETRY.	17081983 [Abstract]