K1C25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C25_HUMAN
• UniProt AC: Q7Z3Z0
• Protein Name: Keratin, type I cytoskeletal 25
• Gene Name: KRT25 {ECO:0000312|HGNC:HGNC:30839}
• Organism: Homo sapiens (Human).
• Sequence Length: 450
• Subcellular Localization: Cytoplasm .
• Protein Description: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization. [PubMed: 26902920]
• Protein Sequence: MSLRLSSASRRSCPRPTTGSLRLYGGGTSFGTGNSCGISGIGSGFSSAFGGSSSGGNTGGGNPCAGFTVNERGLLSGNEKVTMQNLNDRLASYLDSVHALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDDLKNQIIASTTSNANAVLQIDNARLTADDFRLKYENELALHQSVEADVNGLRRVLDEITLCRTDLEIQYETLSEEMTYLKKNHKEEMQVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISEDVGATTSARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLHLEKEIETYCLLIGGDDGACKSGGYKSKDYGSGNVGSQVKDPAKAIVVKKVLEEVDQRSKILTTRLHSLEEKSQSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLRLSSAS ------CCCCCCCCC	23.38	29978859
6	Phosphorylation	--MSLRLSSASRRSC --CCCCCCCCCCCCC	19.88	29978859
7	Phosphorylation	-MSLRLSSASRRSCP -CCCCCCCCCCCCCC	34.55	29978859
9	Phosphorylation	SLRLSSASRRSCPRP CCCCCCCCCCCCCCC	30.12	29978859
115	Phosphorylation	EQKIKGWYEKFGPGS HHHHHHHHHHHCCCC	20.22	-
147	Phosphorylation	LKNQIIASTTSNANA HHCCEEEECCCCCCC	23.08	-
148	Phosphorylation	KNQIIASTTSNANAV HCCEEEECCCCCCCE	25.81	-
149	Phosphorylation	NQIIASTTSNANAVL CCEEEECCCCCCCEE	19.93	-
150	Phosphorylation	QIIASTTSNANAVLQ CEEEECCCCCCCEEE	33.75	-
197	Phosphorylation	RRVLDEITLCRTDLE HHHHHHHHEECCCCH	20.12	-
207	Phosphorylation	RTDLEIQYETLSEEM CCCCHHHHHHHHHHH	19.28	26657352
209	Phosphorylation	DLEIQYETLSEEMTY CCHHHHHHHHHHHHH	30.56	26657352
433	Phosphorylation	LEEVDQRSKILTTRL HHHHHHHHHHHHHHH	20.58	18669648
437	Phosphorylation	DQRSKILTTRLHSLE HHHHHHHHHHHHHHH	17.22	18669648
438	Phosphorylation	QRSKILTTRLHSLEE HHHHHHHHHHHHHHH	27.99	29978859
442	Phosphorylation	ILTTRLHSLEEKSQS HHHHHHHHHHHHHHC	41.91	26160856

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C25_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K1C25_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433; THR-437 ANDSER-442, AND MASS SPECTROMETRY.
PubMed: 18669648