K1C27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C27_HUMAN
• UniProt AC: Q7Z3Y8
• Protein Name: Keratin, type I cytoskeletal 27
• Gene Name: KRT27 {ECO:0000312|HGNC:HGNC:30841}
• Organism: Homo sapiens (Human).
• Sequence Length: 459
• Subcellular Localization: Cytoplasm .
• Protein Description: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs)..
• Protein Sequence: MSVRFSSTSRRLGSCGGTGSVRLSSGGAGFGAGNTCGVPGIGSGFSCAFGGSSSAGGYGGGLGGGSASCAAFTGNEHGLLSGNEKVTMQNLNDRLASYLENVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDELKNQIISATTSNAHVVLQNDNARLTADDFRLKFENELALHQSVEADINGLRRVLDELTLCRTDLEIQLETLSEELAYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISDDAGATTSARNELIEMKRTLQTLEIELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLIDGEDGSCSKSKGYGGPGNQTKDSSKTTIVKTVVEEIDPRGKVLSSRVHTVEEKSTKVNNKNEQRVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	EQKIKGWYEKFGPGS HHHHHHHHHHHCCCC	20.22	-
214	Phosphorylation	DLEIQLETLSEELAY CHHHHHHHHHHHHHH	44.14	22210691
221	Phosphorylation	TLSEELAYLKKNHEE HHHHHHHHHHHCCHH	31.51	-
223	Sumoylation	SEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	-
223	Sumoylation	SEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	-
223	Ubiquitination	SEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	22817900
224	Ubiquitination	EELAYLKKNHEEEMK HHHHHHHHCCHHHHH	62.02	22817900
388	Phosphorylation	LEKEIETYCLLIDGE HHHCEEEEEEEEECC	2.87	-
405	Phosphorylation	SCSKSKGYGGPGNQT CCCCCCCCCCCCCCC	23.73	-
412	Phosphorylation	YGGPGNQTKDSSKTT CCCCCCCCCCCCCCE	40.60	-
417	Acetylation	NQTKDSSKTTIVKTV CCCCCCCCCEEEEEE	54.35	19818711
437	Phosphorylation	PRGKVLSSRVHTVEE CCCCEEHHCEEECHH	33.87	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C27_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C27_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K1C27_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.