EPN1_RAT - dbPTM
EPN1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EPN1_RAT
UniProt AC O88339
Protein Name Epsin-1
Gene Name Epn1
Organism Rattus norvegicus (Rat).
Sequence Length 575
Subcellular Localization Cytoplasm. Cell membrane
Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit. Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the p
Protein Description Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis..
Protein Sequence MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAASDPWGAPAVPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPWGGTPAPAAGEGPTSDPWGSADGGAPVSGPPSSDPWAPAPAFSDPWGGSPAKPSSNGTAVGGFDTEPDEFSDFDRLRTALPTSGSSTGELELLAGEVPARSPGAFDMSGVGGSLAESVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPSGAPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationKNIVHNYSEAEIKVR
HHHHHCCHHHEEEEE		35.3323984901
23UbiquitinationNYSEAEIKVREATSN
CCHHHEEEEEECCCC		27.09-
107UbiquitinationMYAVQTLKDFQYVDR
CCHHEECCCCEEECC		60.94-
117UbiquitinationQYVDRDGKDQGVNVR
EEECCCCCCCCCCHH		51.68-
382PhosphorylationFSDPWGGSPAKPSSN
CCCCCCCCCCCCCCC		20.11-
411PhosphorylationSDFDRLRTALPTSGS
CCHHHHHHCCCCCCC		36.8227097102
415PhosphorylationRLRTALPTSGSSTGE
HHHHCCCCCCCCCCC		46.7127097102
416PhosphorylationLRTALPTSGSSTGEL
HHHCCCCCCCCCCCE		34.4421738781
418PhosphorylationTALPTSGSSTGELEL
HCCCCCCCCCCCEEE		25.2123712012
419PhosphorylationALPTSGSSTGELELL
CCCCCCCCCCCEEEC		43.9128689409
420PhosphorylationLPTSGSSTGELELLA
CCCCCCCCCCEEECC		36.0528689409
434PhosphorylationAGEVPARSPGAFDMS
CCCCCCCCCCCCCCC		29.7727097102
441PhosphorylationSPGAFDMSGVGGSLA
CCCCCCCCCCCHHHH		31.9728551015
446PhosphorylationDMSGVGGSLAESVGS
CCCCCCHHHHHHHCC		20.6227097102
450PhosphorylationVGGSLAESVGSPPPA
CCHHHHHHHCCCCCC		26.6027097102
453PhosphorylationSLAESVGSPPPAATP
HHHHHHCCCCCCCCC		31.8830240740
459PhosphorylationGSPPPAATPTPTPPT
CCCCCCCCCCCCCCC		29.7829779826
461PhosphorylationPPPAATPTPTPPTRK
CCCCCCCCCCCCCCC		35.1325403869
463PhosphorylationPAATPTPTPPTRKTP
CCCCCCCCCCCCCCC		44.3625403869
466PhosphorylationTPTPTPPTRKTPESF
CCCCCCCCCCCCHHH		46.1028432305
469PhosphorylationPTPPTRKTPESFLGP
CCCCCCCCCHHHCCC		29.0621738781
472PhosphorylationPTRKTPESFLGPNAA
CCCCCCHHHCCCCCE		27.2927097102
485PhosphorylationAALVDLDSLVSRPGP
CEEEEHHHHHCCCCC		37.6628432305
488PhosphorylationVDLDSLVSRPGPTPP
EEHHHHHCCCCCCCC		37.7428432305
493PhosphorylationLVSRPGPTPPGAKAS
HHCCCCCCCCCCCCC		48.2923984901
533MethylationTLTLNQLRLSPVPPV
EEEECEEECCCCCCC		24.29-
535PhosphorylationTLNQLRLSPVPPVPG
EECEEECCCCCCCCC		19.8822673903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EPN1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EPN1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EPN1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TBA1A_RATTuba1aphysical
12750376
UBC_RATUbcphysical
14657369
UBC_RATUbcphysical
19536136
CLH1_RATCltcphysical
11382783
CLCA_RATCltaphysical
11382783
AP2B1_RATAp2b1physical
12234931
CLH1_RATCltcphysical
12234931
CLCA_RATCltaphysical
12234931
AP2M1_RATAp2m1physical
12234931
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EPN1_RAT

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Related Literatures of Post-Translational Modification

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