| UniProt ID | CLH1_RAT | |
|---|---|---|
| UniProt AC | P11442 | |
| Protein Name | Clathrin heavy chain 1 | |
| Gene Name | Cltc | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 1675 | |
| Subcellular Localization |
Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side. Membrane, coated pit Peripheral membrane protein Cytoplasmic side. Melanosome. Cytoplasm, cytoskeleton, spindle . Cytoplasmic face of coated pits and vesicles. In complex |
|
| Protein Description | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. [PubMed: 15858577] | |
| Protein Sequence | MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQIWVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNSLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDLLMVLSPRLAHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAQILPIRF ------CCCCCCCCH | - | ||
| 67 | Phosphorylation | NPIRRPISADSAIMN CCCCCCCCCCHHHCC | 28432305 | ||
| 70 | Phosphorylation | RRPISADSAIMNPAS CCCCCCCHHHCCCCH | 28432305 | ||
| 78 | Acetylation | AIMNPASKVIALKAG HHCCCCHHEEEHHCC | 22902405 | ||
| 83 | Acetylation | ASKVIALKAGKTLQI CHHEEEHHCCCEEEE | 22902405 | ||
| 83 | Ubiquitination | ASKVIALKAGKTLQI CHHEEEHHCCCEEEE | - | ||
| 86 | Ubiquitination | VIALKAGKTLQIFNI EEEHHCCCEEEEEEE | - | ||
| 96 | Ubiquitination | QIFNIEMKSKMKAHT EEEEEECHHHCCCCC | - | ||
| 103 | Phosphorylation | KSKMKAHTMTDDVTF HHHCCCCCCCCCCCH | 25575281 | ||
| 105 | Phosphorylation | KMKAHTMTDDVTFWK HCCCCCCCCCCCHHH | 22673903 | ||
| 109 | Phosphorylation | HTMTDDVTFWKWISL CCCCCCCCHHHEEEC | 23984901 | ||
| 151 | S-nitrosocysteine | RHSSLAGCQIINYRT CCCCCCCCEEEECCC | - | ||
| 151 | S-nitrosylation | RHSSLAGCQIINYRT CCCCCCCCEEEECCC | 22178444 | ||
| 163 | Acetylation | YRTDAKQKWLLLTGI CCCCCCCCEEEHHCC | 22902405 | ||
| 184 | Phosphorylation | VVGAMQLYSVDRKVS CCCCEEEEECCCCCC | - | ||
| 191 | Phosphorylation | YSVDRKVSQPIEGHA EECCCCCCCCCCCCC | 28432305 | ||
| 227 | Acetylation | VRGQAGGKLHIIEVG EECCCCCEEEEEEEC | 22902405 | ||
| 235 | Phosphorylation | LHIIEVGTPPTGNQP EEEEEECCCCCCCCC | 28432305 | ||
| 238 | Phosphorylation | IEVGTPPTGNQPFPK EEECCCCCCCCCCCC | 23984901 | ||
| 245 | Ubiquitination | TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC | - | ||
| 245 | Acetylation | TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC | 22902405 | ||
| 245 | Methylation | TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC | 12692561 | ||
| 245 | "N6,N6-dimethyllysine" | TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC | - | ||
| 246 | "N6,N6-dimethyllysine" | GNQPFPKKAVDVFFP CCCCCCCCCEEEECC | - | ||
| 246 | Methylation | GNQPFPKKAVDVFFP CCCCCCCCCEEEECC | 12692561 | ||
| 367 | Acetylation | AEELFARKFNALFAQ HHHHHHHHHHHHHHC | 22902405 | ||
| 382 | Acetylation | GNYSEAAKVAANAPK CCHHHHHHHHHCCCC | 22902405 | ||
| 389 | Ubiquitination | KVAANAPKGILRTPD HHHHCCCCCCCCCHH | - | ||
| 394 | Phosphorylation | APKGILRTPDTIRRF CCCCCCCCHHHHHHH | 29779826 | ||
| 397 | Phosphorylation | GILRTPDTIRRFQSV CCCCCHHHHHHHCCC | 28432305 | ||
| 411 | Phosphorylation | VPAQPGQTSPLLQYF CCCCCCCCCHHHHHH | 28551015 | ||
| 412 | Phosphorylation | PAQPGQTSPLLQYFG CCCCCCCCHHHHHHH | 28551015 | ||
| 450 | Ubiquitination | GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC | - | ||
| 450 | Acetylation | GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC | 22902405 | ||
| 453 | Acetylation | QLLEKWLKEDKLECS HHHHHHHHHCCCHHH | 22902405 | ||
| 619 | Acetylation | HIAQLCEKAGLLQRA HHHHHHHHHCHHHHH | 140843 | ||
| 619 | Ubiquitination | HIAQLCEKAGLLQRA HHHHHHHHHCHHHHH | - | ||
| 634 | Phosphorylation | LEHFTDLYDIKRAVV HHHHHHHHHHHHHHH | 19605366 | ||
| 637 | Acetylation | FTDLYDIKRAVVHTH HHHHHHHHHHHHHHH | 22902405 | ||
| 737 | Succinylation | KYIQAACKTGQIKEV HHHHHHHHCCCHHHH | - | ||
| 737 | Succinylation | KYIQAACKTGQIKEV HHHHHHHHCCCHHHH | - | ||
| 742 | Acetylation | ACKTGQIKEVERICR HHHCCCHHHHHHHHH | 22902405 | ||
| 742 | Ubiquitination | ACKTGQIKEVERICR HHHCCCHHHHHHHHH | - | ||
| 760 | Acetylation | CYDPERVKNFLKEAK CCCHHHHHHHHHHCC | 8263565 | ||
| 764 | Acetylation | ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC | 22902405 | ||
| 795 | Phosphorylation | VLYLYRNSLQKYIEI HHHHHHHCHHHHHHH | 25575281 | ||
| 799 | Phosphorylation | YRNSLQKYIEIYVQK HHHCHHHHHHHHEEC | 25575281 | ||
| 825 | Phosphorylation | GLLDVDCSEDVIKNL CCCCCCCCHHHHHHH | 25403869 | ||
| 851 | Acetylation | ELVAEVEKRNRLKLL HHHHHHHHHCHHHHH | 22902405 | ||
| 856 | Acetylation | VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH | - | ||
| 856 | Ubiquitination | VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH | - | ||
| 870 | S-nitrosocysteine | EARIHEGCEEPATHN HHHHHCCCCCCCCCC | - | ||
| 870 | S-nitrosylation | EARIHEGCEEPATHN HHHHHCCCCCCCCCC | 22178444 | ||
| 881 | Ubiquitination | ATHNALAKIYIDSNN CCCCCEEEEEECCCC | - | ||
| 883 | Phosphorylation | HNALAKIYIDSNNNP CCCEEEEEECCCCCH | 27097102 | ||
| 899 | Phosphorylation | RFLRENPYYDSRVVG HHHCCCCCCCHHHHH | 27097102 | ||
| 900 | Phosphorylation | FLRENPYYDSRVVGK HHCCCCCCCHHHHHH | 27097102 | ||
| 902 | Phosphorylation | RENPYYDSRVVGKYC CCCCCCCHHHHHHHH | 27097102 | ||
| 941 | Ubiquitination | CNENSLFKSLSRYLV CCCCHHHHHHHHHHH | - | ||
| 1096 | Phosphorylation | IGNLDRAYEFAERCN HCCHHHHHHHHHHCC | 30181290 | ||
| 1167 | Phosphorylation | ARKKARESYVETELI HHHHHHHHHHHHHHH | 23984901 | ||
| 1168 | Phosphorylation | RKKARESYVETELIF HHHHHHHHHHHHHHH | 23984901 | ||
| 1171 | Phosphorylation | ARESYVETELIFALA HHHHHHHHHHHHHHH | 23984901 | ||
| 1206 | Phosphorylation | QQVGDRCYDEKMYDA HHHHHHHCCHHHHHH | - | ||
| 1211 | Phosphorylation | RCYDEKMYDAAKLLY HHCCHHHHHHHHHHH | - | ||
| 1215 | Acetylation | EKMYDAAKLLYNNVS HHHHHHHHHHHHCCC | 22902405 | ||
| 1229 | Phosphorylation | SNFGRLASTLVHLGE CHHHHHHHHHHHHHC | 23984901 | ||
| 1230 | Phosphorylation | NFGRLASTLVHLGEY HHHHHHHHHHHHHCH | 23984901 | ||
| 1237 | Phosphorylation | TLVHLGEYQAAVDGA HHHHHHCHHHHHCCC | 23984901 | ||
| 1347 | Ubiquitination | WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH | - | ||
| 1347 | Acetylation | WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH | 22902405 | ||
| 1392 | Acetylation | AWKEGQFKDIITKVA HHHCCCHHHHHHHHH | 22902405 | ||
| 1438 | Phosphorylation | AHTRAVNYFSKVKQL HCHHHHHHHHCCCCC | - | ||
| 1441 | Acetylation | RAVNYFSKVKQLPLV HHHHHHHCCCCCCCC | 22902405 | ||
| 1441 | Succinylation | RAVNYFSKVKQLPLV HHHHHHHCCCCCCCC | - | ||
| 1441 | Succinylation | RAVNYFSKVKQLPLV HHHHHHHCCCCCCCC | - | ||
| 1441 | Ubiquitination | RAVNYFSKVKQLPLV HHHHHHHCCCCCCCC | - | ||
| 1449 | Acetylation | VKQLPLVKPYLRSVQ CCCCCCCHHHHHHHH | 22902405 | ||
| 1454 | Phosphorylation | LVKPYLRSVQNHNNK CCHHHHHHHHHCCCC | 27097102 | ||
| 1462 | Phosphorylation | VQNHNNKSVNESLNN HHHCCCCCHHHHHHH | 27097102 | ||
| 1466 | Phosphorylation | NNKSVNESLNNLFIT CCCCHHHHHHHCCCC | 27097102 | ||
| 1473 | Phosphorylation | SLNNLFITEEDYQAL HHHHCCCCHHHHHHH | - | ||
| 1477 | Phosphorylation | LFITEEDYQALRTSI CCCCHHHHHHHHHHH | 27097102 | ||
| 1482 | Phosphorylation | EDYQALRTSIDAYDN HHHHHHHHHHHHCCC | 27097102 | ||
| 1483 | Phosphorylation | DYQALRTSIDAYDNF HHHHHHHHHHHCCCC | 27097102 | ||
| 1487 | Phosphorylation | LRTSIDAYDNFDNIS HHHHHHHCCCCCCCC | 27097102 | ||
| 1494 | Phosphorylation | YDNFDNISLAQRLEK CCCCCCCCHHHHHHH | 29779826 | ||
| 1501 | Acetylation | SLAQRLEKHELIEFR CHHHHHHHHCHHHHH | 22902405 | ||
| 1513 | Phosphorylation | EFRRIAAYLFKGNNR HHHHHHHHHHHCCCH | - | ||
| 1516 | Acetylation | RIAAYLFKGNNRWKQ HHHHHHHHCCCHHHH | 22902405 | ||
| 1524 | Phosphorylation | GNNRWKQSVELCKKD CCCHHHHHHHHHHCC | 27097102 | ||
| 1609 | Ubiquitination | VMKEYLTKVDKLDAS HHHHHHHHHHHCCHH | - | ||
| 1612 | Acetylation | EYLTKVDKLDASESL HHHHHHHHCCHHHHH | 22902405 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLH1_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLH1_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLH1_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CLH1_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
