CXB5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXB5_HUMAN
• UniProt AC: O95377
• Protein Name: Gap junction beta-5 protein
• Gene Name: GJB5
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
• Protein Sequence: MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Phosphorylation	GENSGRLYLNPGKKR CCCCCCEEECCCCCC	11.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXB5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXB5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXB5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLRV_HUMAN	MYL2	physical	21988832
MED1_HUMAN	MED1	physical	21988832
PCGF2_HUMAN	PCGF2	physical	21988832
TRIM2_HUMAN	TRIM2	physical	21988832
CLH1_HUMAN	CLTC	physical	25388970

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.