| UniProt ID | RN217_HUMAN | |
|---|---|---|
| UniProt AC | Q8TC41 | |
| Protein Name | Probable E3 ubiquitin-protein ligase RNF217 | |
| Gene Name | RNF217 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 542 | |
| Subcellular Localization |
Membrane Single-pass membrane protein . |
|
| Protein Description | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.. | |
| Protein Sequence | MGEEQSTVSGGGGPQESQTLASGTAGHPEPPRPQGDSARAPPLRAASAEPSGGGCGSDWGCADTSAPEPARSLGPPGWSKSRAPAQPAGLALTGPLNPQTLPLQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAKRQVFCSVYCVESDLPEAPASEQLSPPASPPGAPPVLNPPSTRSSFPSPRLSLPTDSLSPDGGSIELEFYLAPEPFSMPSLLGAPPYSGLGGVGDPYVPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKVYLSAQVQLGQVEIKCPITECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGHIPTPSRSESKYKIQCPTCQFVWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRKRSRTGMHW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 156 | Phosphorylation | VLGQRRPSLAKRQVF HHCCCCCCHHHCCEE | 3.49 | 25159151 | |
| 183 | Ubiquitination | APASEQLSPPASPPG CCHHHCCCCCCCCCC | 32.89 | 2189047 | |
| 202 | Phosphorylation | LNPPSTRSSFPSPRL CCCCCCCCCCCCCCC | 4.41 | 30266825 | |
| 203 | Phosphorylation | NPPSTRSSFPSPRLS CCCCCCCCCCCCCCC | 18.92 | 30266825 | |
| 206 | Phosphorylation | STRSSFPSPRLSLPT CCCCCCCCCCCCCCC | 3.52 | 30266825 | |
| 363 | Phosphorylation | KKKGHIPTPSRSESK CCCCCCCCCCCCCCC | - | ||
| 365 | Phosphorylation | KGHIPTPSRSESKYK CCCCCCCCCCCCCCE | 29457462 | ||
| 411 | Phosphorylation | KLLRHWASEIEHGQR HHHHHHHHHHHHHHH | 28555341 | ||
| 456 | Phosphorylation | CYRCGERYRQLRFFG HHHCCHHHHEEEEEC | 22617229 | ||
| 475 | Ubiquitination | NLSIFGCKYRYLPER CEEEECEECCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RN217_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RN217_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RN217_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HAX1_HUMAN | HAX1 | physical | 25298122 | |
| ACTBL_HUMAN | ACTBL2 | physical | 28514442 | |
| H1FNT_HUMAN | H1FNT | physical | 28514442 | |
| ACTA_HUMAN | ACTA2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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