H1FNT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H1FNT_HUMAN
• UniProt AC: Q75WM6
• Protein Name: Testis-specific H1 histone
• Gene Name: H1FNT
• Organism: Homo sapiens (Human).
• Sequence Length: 255
• Subcellular Localization: Nucleus . Chromosome . In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole.
• Protein Description: Essential for normal spermatogenesis and male fertility. [PubMed: 16533358 Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.]
• Protein Sequence: MEQALTGEAQSRWPRRGGSGAMAEAPGPSGESRGHSATQLPAEKTVGGPSRGCSSSVLRVSQLVLQAISTHKGLTLAALKKELRNAGYEVRRKSGRHEAPRGQAKATLLRVSGSDAAGYFRVWKVPKPRRKPGRARQEEGTRAPWRTPAAPRSSRRRRQPLRKAARKAREVWRRNARAKAKANARARRTRRARPRAKEPPCARAKEEAGATAADEGRGQAVKEDTTPRSGKDKRRSSKPREEKQEPKKPAQRTIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEQALTGEAQSRW --CCCCCCCCCHHCC	35.67	29083192
11	Phosphorylation	ALTGEAQSRWPRRGG CCCCCCHHCCCCCCC	43.28	29083192
36	Phosphorylation	SGESRGHSATQLPAE CCCCCCCCCCCCCCC	35.52	30622161
38	Phosphorylation	ESRGHSATQLPAEKT CCCCCCCCCCCCCCC	33.38	30622161
45	Phosphorylation	TQLPAEKTVGGPSRG CCCCCCCCCCCCCCC	18.85	23312004
54	Phosphorylation	GGPSRGCSSSVLRVS CCCCCCCCHHHHHHH	28.59	25072903
55	Phosphorylation	GPSRGCSSSVLRVSQ CCCCCCCHHHHHHHH	28.66	25072903
56	Phosphorylation	PSRGCSSSVLRVSQL CCCCCCHHHHHHHHH	14.63	25072903
69	Phosphorylation	QLVLQAISTHKGLTL HHHHHHHHHCCCCHH	27.72	30622161
70	Phosphorylation	LVLQAISTHKGLTLA HHHHHHHHCCCCHHH	22.84	22210691
94	Phosphorylation	GYEVRRKSGRHEAPR CHHHHCCCCCCCCCC	38.97	30622161
107	Phosphorylation	PRGQAKATLLRVSGS CCCCCEEEEEEEECC	26.14	30622161
112	Phosphorylation	KATLLRVSGSDAAGY EEEEEEEECCCHHCE	26.58	30622161
114	Phosphorylation	TLLRVSGSDAAGYFR EEEEEECCCHHCEEE	19.30	30622161
119	Phosphorylation	SGSDAAGYFRVWKVP ECCCHHCEEEEEECC	5.40	30622161
147	Phosphorylation	GTRAPWRTPAAPRSS CCCCCCCCCCCCCCH	17.26	30622161
211	Phosphorylation	AKEEAGATAADEGRG HHHHHCCCCCCCCCC	22.81	30622161
225	Phosphorylation	GQAVKEDTTPRSGKD CCCCCCCCCCCCCCC	39.53	30622161
226	Phosphorylation	QAVKEDTTPRSGKDK CCCCCCCCCCCCCCC	29.09	30622161
253	Phosphorylation	PKKPAQRTIQ----- CCCCCHHCCC-----	16.20	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H1FNT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H1FNT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H1FNT_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of H1FNT_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.