| UniProt ID | S26A9_HUMAN | |
|---|---|---|
| UniProt AC | Q7LBE3 | |
| Protein Name | Solute carrier family 26 member 9 | |
| Gene Name | SLC26A9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 791 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.. | |
| Protein Sequence | MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 336 | Phosphorylation | QWKDMIGTAFSLAIV HHHHHHHHHHHHHHH | 17.38 | 22210691 | |
| 344 | Phosphorylation | AFSLAIVSYVINLAM HHHHHHHHHHHHHHH | 13.94 | 24719451 | |
| 345 | Phosphorylation | FSLAIVSYVINLAMG HHHHHHHHHHHHHHC | 8.41 | 22210691 | |
| 432 | Phosphorylation | YLYPLPKSVLGALIA HHCCCCHHHHHHHHH | 22.19 | - | |
| 519 | Phosphorylation | DIYVNPKTYNRAQDI CEECCHHHCCCCCCC | 27.56 | - | |
| 520 | Phosphorylation | IYVNPKTYNRAQDIQ EECCHHHCCCCCCCC | 14.58 | - | |
| 533 | Phosphorylation | IQGIKIITYCSPLYF CCCCEEEEEECCCCC | 23.19 | 28111955 | |
| 534 | Phosphorylation | QGIKIITYCSPLYFA CCCEEEEEECCCCCC | 4.78 | 28111955 | |
| 536 | Phosphorylation | IKIITYCSPLYFANS CEEEEEECCCCCCCH | 13.92 | 28111955 | |
| 539 | Phosphorylation | ITYCSPLYFANSEIF EEEECCCCCCCHHHH | 12.20 | 28111955 | |
| 543 | Phosphorylation | SPLYFANSEIFRQKV CCCCCCCHHHHHHHH | 28.74 | 28111955 | |
| 585 | O-linked_Glycosylation | RPTQQRRSLFMKTKT CCHHHHHHHHHHHCE | 28.31 | 29351928 | |
| 762 | Phosphorylation | GDAELSLYDSEEDIR CCCEEEEECCHHHHH | 17.66 | 22817900 | |
| 764 | Phosphorylation | AELSLYDSEEDIRSY CEEEEECCHHHHHHH | 29.36 | 26657352 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S26A9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S26A9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S26A9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of S26A9_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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