SYPL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYPL1_HUMAN
• UniProt AC: Q16563
• Protein Name: Synaptophysin-like protein 1
• Gene Name: SYPL1
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Subcellular Localization: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome . Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV..
• Protein Sequence: MAPNIYLVRQRISRLGQRMSGFQINLNPLKEPLGFIKVLEWIASIFAFATCGGFKGQTEIQVNCPPAVTENKTVTATFGYPFRLNEASFQPPPGVNICDVNWKDYVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTSLYLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDIKIATGHNIIDELPPCKKKAVLCYFGSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSPSNTSAPHSQGGIPPPTGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	13.07	29507054
20	Phosphorylation	SRLGQRMSGFQINLN HHHHHHHCCEECCCC	38.35	20873877
30	Ubiquitination	QINLNPLKEPLGFIK ECCCCCCCCCHHHHH	59.55	-
71	N-linked_Glycosylation	CPPAVTENKTVTATF CCCCCCCCCEEEEEE	35.61	17660510
77	Phosphorylation	ENKTVTATFGYPFRL CCCEEEEEECCCEEE	14.29	28152594
80	Phosphorylation	TVTATFGYPFRLNEA EEEEEECCCEEECCC	8.59	28152594
179	2-Hydroxyisobutyrylation	AKALTDIKIATGHNI HHHHCCCEECCCCCH	29.15	-
194	2-Hydroxyisobutyrylation	IDELPPCKKKAVLCY HHCCCCCCCCEEEEE	64.18	-
212	N-linked_Glycosylation	VTSMGSLNVSVIFGF CCCCCCCCHHHHHHH	26.22	UniProtKB CARBOHYD
236	Phosphorylation	AWFVYKETSLHSPSN EEEEEEECCCCCCCC	32.22	25693802
237	Phosphorylation	WFVYKETSLHSPSNT EEEEEECCCCCCCCC	25.77	25693802
240	Phosphorylation	YKETSLHSPSNTSAP EEECCCCCCCCCCCC	35.00	25693802
242	Phosphorylation	ETSLHSPSNTSAPHS ECCCCCCCCCCCCCC	56.61	25693802
244	Phosphorylation	SLHSPSNTSAPHSQG CCCCCCCCCCCCCCC	30.51	25693802
245	Phosphorylation	LHSPSNTSAPHSQGG CCCCCCCCCCCCCCC	44.01	25693802
249	Phosphorylation	SNTSAPHSQGGIPPP CCCCCCCCCCCCCCC	29.48	25693802
257	Phosphorylation	QGGIPPPTGI----- CCCCCCCCCC-----	53.97	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYPL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYPL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYPL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAMP8_HUMAN	VAMP8	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
VAMP2_HUMAN	VAMP2	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71, AND MASS SPECTROMETRY.
PubMed: 19159218