FAM3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAM3B_HUMAN
• UniProt AC: P58499
• Protein Name: Protein FAM3B
• Gene Name: FAM3B
• Organism: Homo sapiens (Human).
• Sequence Length: 235
• Subcellular Localization: Secreted. Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
• Protein Description: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner..
• Protein Sequence: MRPLAGGLLKVVFVVFASLCAWYSGYLLAELIPDAPLSSAAYSIRSIGERPVLKAPVPKRQKCDHWTPCPSDTYAYRLLSGGGRSKYAKICFEDNLLMGEQLGNVARGINIAIVNYVTGNVTATRCFDMYEGDNSGPMTKFIQSAAPKSLLFMVTYDDGSTRLNNDAKNAIEALGSKEIRNMKFRSSWVFIAAKGLELPSEIQREKINHSDAKNNRYSGWPAEIQIEGCIPKERS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	PLSSAAYSIRSIGER CCCCCCCCCCCCCCC	13.55	24719451
80	Phosphorylation	TYAYRLLSGGGRSKY CHHHHHHCCCCCCCE	39.73	-
116	Phosphorylation	INIAIVNYVTGNVTA CEEEEEEECCCCEEE	6.62	27067055
120	N-linked_Glycosylation	IVNYVTGNVTATRCF EEEECCCCEEEEEEE	20.71	UniProtKB CARBOHYD
186	Phosphorylation	IRNMKFRSSWVFIAA HHCCCCCCCEEEEEE	31.52	22210691
187	Phosphorylation	RNMKFRSSWVFIAAK HCCCCCCCEEEEEEC	24.01	22210691
200	Phosphorylation	AKGLELPSEIQREKI ECCCCCCHHHHHHHC	61.01	22210691
208	N-linked_Glycosylation	EIQREKINHSDAKNN HHHHHHCCCHHHCCC	39.41	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAM3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAM3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAM3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TM9S4_HUMAN	TM9SF4	physical	28514442
ITPA_HUMAN	ITPA	physical	28514442
CAR19_HUMAN	C9orf89	physical	28514442
GNPTA_HUMAN	GNPTAB	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.